6-BROMO-[1,8]NAPHTHYRIDIN-2-OL
- Product Name
- 6-BROMO-[1,8]NAPHTHYRIDIN-2-OL
- CAS No.
- 72754-05-3
- Chemical Name
- 6-BROMO-[1,8]NAPHTHYRIDIN-2-OL
- Synonyms
- 6-BroMo-[1,8]Naphthyridin-2-One;6-BroMo-1H-[1,8]naphthyridin-2-one;6-BroMo-2-hydroxy-1,8-naphthyridine;6-BROMO-[1,8]NAPHTHYRIDIN-2(1H)-ONE;1,8-Naphthyridin-2(1H)-one, 6-bromo-
- CBNumber
- CB91478667
- Molecular Formula
- C8H5BrN2O
- Formula Weight
- 225.04
- MOL File
- 72754-05-3.mol
6-BROMO-[1,8]NAPHTHYRIDIN-2-OL Property
- Melting point:
- >300℃
- Boiling point:
- 415.9±45.0 °C(Predicted)
- Density
- 1.711
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- pka
- 9.93±0.20(Predicted)
- Appearance
- Light yellow to light brown Solid
- Water Solubility
- Insoluble in water.
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36/37/38-22-41-37/38
- Safety Statements
- 22-26-36/37/39-39
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- ADE000844
- Product name
- 6-Bromo-1,8-naphthyridin-2-ol
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $817
- Updated
- 2025/07/31
- Product number
- FB144388
- Product name
- 6-Bromo-1,8-naphthyridin-2-ol
- Packaging
- 2g
- Price
- $375
- Updated
- 2021/12/16
- Product number
- 211223
- Product name
- 6-Bromo-1,8-naphthyridin-2-ol
- Packaging
- 250mg
- Price
- $42
- Updated
- 2021/12/16
- Product number
- FB144388
- Product name
- 6-Bromo-1,8-naphthyridin-2-ol
- Packaging
- 250mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- Y9930
- Product name
- 6-Bromo-[1,8]naphthyridin-2(1H)-one
- Packaging
- 5g
- Price
- $523
- Updated
- 2021/12/16
6-BROMO-[1,8]NAPHTHYRIDIN-2-OL Chemical Properties,Usage,Production
Uses
6-Bromo-1,8-naphthyridin-2(1H)-one is used as an organic chemical synthesis intermediate.
Synthesis
894853-42-0
72754-05-3
Tert-butyl 3-(2-amino-5-bromopyridin-3-yl)acrylate (2.5 g, 8.35 mmol) was dissolved in anhydrous methanol (50 mL) and sodium methanolate (8.5 mL, 4.9 M solution, 41.75 mmol) was added. The reaction mixture was heated to reflux for 2 hours and subsequently cooled to room temperature. The mixture was cooled in an ice water bath and water (100 mL) was added with vigorous stirring to precipitate. The solid was collected by filtration and washed with water (20 mL). The filtrate was neutralized with 1 M aqueous hydrochloric acid, precipitated again, filtered and washed with water (20 mL). The solids obtained twice were combined and dried under reduced pressure to give the off-white target product 6-bromo-1,8-naphthyridin-2(1H)-one (1.75 g, 93% yield). The product was confirmed by 1H NMR (300 MHz, DMSO-d6): δ 8.43 (d, 1H, J=2.5Hz), 8.06 (d, 1H, J=2.5Hz), 7.60 (d, 1H, J=9.1Hz), 6.44 (d, 1H, J=9.1Hz); ESIMS m/z 225 (100%), 227 (100%) ) [C8H5N2OBr + H]+.
References
[1] Patent: WO2007/53131, 2007, A2. Location in patent: Page/Page column 203
[2] Patent: WO2015/186137, 2015, A1. Location in patent: Page/Page column 16
6-BROMO-[1,8]NAPHTHYRIDIN-2-OL Preparation Products And Raw materials
Raw materials
Preparation Products
6-BROMO-[1,8]NAPHTHYRIDIN-2-OL Suppliers
- Tel
- --
- Fax
- --
- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@manchesterorganics.com
- Country
- United Kingdom
- ProdList
- 6834
- Advantage
- 67
View Lastest Price from 6-BROMO-[1,8]NAPHTHYRIDIN-2-OL manufacturers
- Product
- 6-BROMO-[1,8]NAPHTHYRIDIN-2-OL 72754-05-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2020-03-05