Ethyl 2-amino-3-cyclobutylpropanoate
- Product Name
- Ethyl 2-amino-3-cyclobutylpropanoate
- CAS No.
- 394735-17-2
- Chemical Name
- Ethyl 2-amino-3-cyclobutylpropanoate
- Synonyms
- Ethyl 3-cyclobutylalaninate;3-Cyclobutylalanine ethyl etser;Ethyl 2-amino-3-cyclobutylpropanoate;2-amino-3-cyclobutylpropanoic acid ethyl ester;Cyclobutanepropanoicacid, a-amino-, ethyl ester;2-AMino-3-cyclobutyl-propionic acid ethyl ester;Cyclobutanepropanoic acid, α-amino-, ethyl ester
- CBNumber
- CB91482037
- Molecular Formula
- C9H17NO2
- Formula Weight
- 171.24
- MOL File
- 394735-17-2.mol
Ethyl 2-amino-3-cyclobutylpropanoate Property
- Boiling point:
- 227.8±13.0 °C(Predicted)
- Density
- 1.034
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- form
- Liquid
- pka
- 8.11±0.33(Predicted)
Safety
- HS Code
- 2922498590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E899928
- Product name
- Ethyl2-amino-3-cyclobutylpropanoate
- Packaging
- 50mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- E899928
- Product name
- Ethyl2-amino-3-cyclobutylpropanoate
- Packaging
- 100mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- AAA0010808
- Product name
- ETHYL 2-AMINO-3-CYCLOBUTYLPROPANOATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.18
- Updated
- 2021/12/16
- Product number
- 5159AB
- Product name
- Ethyl2-amino-3-cyclobutylpropanoate
- Packaging
- 5g
- Price
- $651
- Updated
- 2021/12/16
- Product number
- AAA0010808
- Product name
- ETHYL 2-AMINO-3-CYCLOBUTYLPROPANOATE
- Purity
- 95.00%
- Packaging
- 0.25G
- Price
- $670
- Updated
- 2021/12/16
Ethyl 2-amino-3-cyclobutylpropanoate Chemical Properties,Usage,Production
Synthesis
17247-58-4
69555-14-2
394735-17-2
Example-1: Preparation of ethyl 2-amino-3-cyclobutylpropionate (formula-4a) Ethyl 2-(diphenylmethyleneamino) acetate (Formula-A3, 250 g) was dissolved in tetrahydrofuran (2000 mL) and the mixture was cooled to 0-5°C. Potassium tert-butoxide (157.4 g) was slowly added at a temperature below 10°C and stirred at 0-5°C for 1 hour. Subsequently, bromomethylcyclobutane (185 g) was slowly added over 30 minutes at 0-5 °C. The reaction mixture was warmed to 25-30 °C and stirring was continued for 30 hours. After completion of the reaction, 2N hydrochloric acid was added to the reaction mixture and stirred for 6 hours. Dichloromethane was added and after stirring for 15 minutes, the organic and aqueous layers were separated. The aqueous layer was washed with dichloromethane. Dichloromethane was added to the aqueous layer and cooled to 0-5°C. The pH of the reaction mixture was adjusted to 12.5 with 50% sodium hydroxide solution, stirred for 10 minutes and the organic and aqueous layers were separated again. The aqueous layer was extracted with dichloromethane at 0-5°C. All organic layers were combined, dried with anhydrous sodium sulfate and the solvent was removed by distillation under reduced pressure to give the target product ethyl 2-amino-3-cyclobutylpropionate. Yield: 45 g.
References
[1] Letters in Organic Chemistry, 2016, vol. 13, # 5, p. 352 - 358
[2] Patent: WO2005/85197, 2005, A1. Location in patent: Page/Page column 58-59
[3] Patent: US2006/276407, 2006, A1. Location in patent: Page/Page column 410
[4] Patent: US2006/281688, 2006, A1. Location in patent: Page/Page column 622
[5] Patent: WO2014/61034, 2014, A1. Location in patent: Page/Page column 9; 27; 35
Ethyl 2-amino-3-cyclobutylpropanoate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl 2-amino-3-cyclobutylpropanoate manufacturers
- Product
- Ethyl 2-amino-3-cyclobutylpropanoate 394735-17-2
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2020-01-13