ChemicalBook > CAS DataBase List > 5-(METHOXYCARBONYL)THIOPHENE-2-CARBOXYLIC ACID

5-(METHOXYCARBONYL)THIOPHENE-2-CARBOXYLIC ACID

Product Name
5-(METHOXYCARBONYL)THIOPHENE-2-CARBOXYLIC ACID
CAS No.
50340-79-9
Chemical Name
5-(METHOXYCARBONYL)THIOPHENE-2-CARBOXYLIC ACID
Synonyms
2-Methyl 2,5-thiophenedicarboxylate;2,5-Thiophenedicarboxylicacid,monomethylester;2,5-Thiophenedicarboxylic acid, 2-methyl ester;5-(METHOXYCARBONYL)THIOPHENE-2-CARBOXYLIC ACID
CBNumber
CB91491679
Molecular Formula
C7H6O4S
Formula Weight
186.19
MOL File
50340-79-9.mol
More
Less

5-(METHOXYCARBONYL)THIOPHENE-2-CARBOXYLIC ACID Property

Melting point:
187-190℃
Boiling point:
365.2±27.0 °C(Predicted)
Density 
1.439±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
pka
3.04±0.10(Predicted)
Appearance
White to yellow Solid
More
Less

Safety

Risk Statements 
20/21/22
Safety Statements 
3/9-24/25-36/37
HazardClass 
IRRITANT
HS Code 
29349990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H320Causes eye irritation

H341Suspected of causing genetic defects

H350May cause cancer

H370Causes damage to organs

H373May cause damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

TRC
Product number
M329865
Product name
5-(Methoxycarbonyl)thiophene-2-carboxylicacid
Packaging
250mg
Price
$55
Updated
2021/12/16
TRC
Product number
M329865
Product name
5-(Methoxycarbonyl)thiophene-2-carboxylicacid
Packaging
1g
Price
$75
Updated
2021/12/16
Matrix Scientific
Product number
008150
Product name
Thiophene-2,5-dicarboxylic acid monomethyl ester
Purity
95+%
Packaging
1g
Price
$55
Updated
2021/12/16
AK Scientific
Product number
Z3443
Product name
Thiophene-2,5-dicarboxylicacidmonomethylester
Packaging
5g
Price
$284
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0097084
Product name
THIOPHENE-2,5-DICARBOXYLIC ACID MONOMETHYL ESTER
Purity
95.00%
Packaging
1G
Price
$852.55
Updated
2021/12/16
More
Less

5-(METHOXYCARBONYL)THIOPHENE-2-CARBOXYLIC ACID Chemical Properties,Usage,Production

Chemical Properties

White solid

Synthesis

4282-34-2

50340-79-9

The general procedure for the synthesis of methyl 5-carboxylic acid-2-thiophenecarboxylate from dimethyl thiophene-2,5-dicarboxylate is as follows: to a mildly refluxed solution of dimethyl thiophene-2,5-dicarboxylate (0.430 g, 2.15 mmol) in dioxane/methanol (1:2, 1.5 ml) was added an aqueous sodium hydroxide solution (0.086 g, 2.15 mmol, dissolved in 0.5 ml of water). The reaction mixture was kept under stirring for 5 hours and subsequently cooled to room temperature. After adjusting the pH of the reaction solution to 2 with 1N hydrochloric acid, it was extracted with ethyl acetate (3 x 30 ml). The organic phases were combined, washed with brine (1 x 5 ml), dried over anhydrous magnesium sulfate and concentrated under reduced pressure to afford monomethyl thiophene-2,5-dicarboxylate as a white solid (0.342 g, 86% yield). The product was characterized by 1H NMR (CD3OD): δH 7.72-7.73 (d, 1H), 7.69-7.70 (d, 1H), 3.87 (s, 3H).

Structure and conformation

Thiophene-2,5-dicarboxylic acid monomethyl ester (TDCEM) has been shown to form dimers in solution. The crystal structure of TDCEM has been determined and found to be centrosymmetric with hydrogen bonds between the carbonyl oxygen atoms and the methyl groups on either side, as well as dihedral angles for the two methyl groups.

References

[1] Chemistry - A European Journal, 2016, vol. 22, # 33, p. 11785 - 11794
[2] Patent: US2004/2524, 2004, A1
[3] Patent: WO2004/817, 2003, A2. Location in patent: Page 99
[4] Patent: US2680731, 1950,

5-(METHOXYCARBONYL)THIOPHENE-2-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

5-(METHOXYCARBONYL)THIOPHENE-2-CARBOXYLIC ACID Suppliers

China 65 Finland 1 Germany 3 India 2 Ukraine 1 United States 7 Global 79
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Nanjing Habo Medical Technology Co., Ltd.
Tel
025-85760892 13376080562
Fax
025-85766769
Email
sales@habotech.com
Country
China
ProdList
884
Advantage
60
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
Nanjing Vital Chemical Co., Ltd.
Tel
Please Send Email 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
4378
Advantage
65
SynAsst Chemical.
Tel
021-60343070
Fax
021-35122006
Country
China
ProdList
12740
Advantage
55
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Shanghai HuanChuan Industry Co.,Ltd.
Tel
021-61478794
Fax
021-61478794
Email
sales@hcshhai.com
Country
China
ProdList
9793
Advantage
50
Shanghai Song Yuan Chemical Technology Co., Ltd.
Tel
010-1234567 18521000990
Fax
86-021-33275113
Email
sonyuanchemical@163.com
Country
China
ProdList
6479
Advantage
50
Credit Asia Chemical Co., Ltd.
Tel
+86 (21) 61124340
Fax
+86 (21) 6129-4103
Country
China
ProdList
9756
Advantage
58
Cool Pharm, Ltd
Tel
021-60455363 18019463053
Fax
50966098
Email
sales@coolpharm.com
Country
China
ProdList
12346
Advantage
58
Nanjing Endesa Bio-tech Co., Ltd.
Tel
025-58862853 18915922038
Fax
+86-025-58862853
Email
sales@endesachem.com
Country
China
ProdList
591
Advantage
58
Chengdu RunZeBenTu Chemical Co., Ltd
Tel
028-88469284 18000562381
Email
rzbtsj@163.com
Country
China
ProdList
9951
Advantage
56
Nanjing Vital Chemical Co., Ltd.
Tel
025-87193546 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
9021
Advantage
60
Henan CoreyChem Co., Ltd
Tel
0371-86658258
Fax
0371-60996044
Email
info@coreychem.com
Country
China
ProdList
10453
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Aikon International Limited
Tel
025-66061636 18013972705
Fax
(3)02557626880
Email
qqyang@aikonchem.com
Country
China
ProdList
15814
Advantage
58
Shanghai HongMin Pharmaceutical Co., Ltd.
Tel
13651987816
Fax
-
Email
hongminpharm@163.com
Country
China
ProdList
2326
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52687
Advantage
58
Zhuzhou focus pharmaceutical technology co., LTD
Tel
+86-13776644403
Email
robert@focuspharma.cc
Country
China
ProdList
2459
Advantage
58
Hunan Jibang Biological Technology Co., LTD
Tel
+8613776644403
Email
sales02@kingboomtech.com
Country
China
ProdList
1804
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
+86-0551-65418671 +8618949823763
Fax
0551-65418697
Email
sales@tnjchem.com
Country
China
ProdList
34563
Advantage
58
Dayang Chem (Hangzhou) Co.,Ltd.
Tel
+86-0571-88938639 +8617705817739
Fax
+86-571-88938652，+86-571- 88492614
Email
info@dycnchem.com
Country
China
ProdList
52846
Advantage
58
HaBo Hong Kong Co., Limited.
Tel
+86-25-18512596065
Email
info@habotech.com
Country
CHINA
ProdList
933
Advantage
58
Jiaozuo Vaughan Biotechnology Co., Ltd.
Tel
0391-3702345 18739121806
Email
sales@wnbiopharm.com
Country
China
ProdList
829
Advantage
58
CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
Country
China
ProdList
49975
Advantage
58
career henan chemical co
Tel
+86-0371-86658258 +8613203830695
Fax
0086-371-86658258
Email
factory@coreychem.com
Country
China
ProdList
29798
Advantage
58
Antai Fine Chemical Technology Co.,Limited
Tel
18503026267
Email
info@antaichem.com
Country
CHINA
ProdList
9636
Advantage
58
Taizhou Nanfeng Pharmaceutical Research Institute
Tel
nanfengdrug@163.com; 18616377689
Email
nanfengdrug@163.com
Country
China
ProdList
20009
Advantage
58
Neostar United (Changzhou) Industrial Co., Ltd.
Tel
+86-0519-85551759 +8613506123987
Fax
+0086-519-85557389
Email
marketing1@neostarunited.com
Country
China
ProdList
8830
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29757
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 4008210725
Email
malulu@leyan.com
Country
China
ProdList
40000
Advantage
58
Beijing Stronger Science Co., Ltd.
Tel
0531-88924771 15614660963
Email
elsa.hang@strongerscience.com
Country
China
ProdList
10623
Advantage
58
Bide Pharmatech Ltd.
Tel
400-6005915
Email
sales@picasso-e.com
Country
China
ProdList
39653
Advantage
58
Jiaxing Zhejia Biotechnology Co., LTD
Tel
0573-85609002 18367600069;
Email
zhejia01@163.com
Country
China
ProdList
8886
Advantage
58
Taizhou Guoci Pharmaceutical Technology Co. LTD
Tel
13575460036
Email
921220106@qq.com
Country
China
ProdList
65
Advantage
58
Zhengzhou Hong Sheng Pharmaceutical Technology Co. Ltd.
Tel
0371-55695890 15637198702
Email
1677336983@qq.com
Country
China
ProdList
13191
Advantage
58
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
18621169109
Email
market03@meryer.com
Country
China
ProdList
27987
Advantage
58
Entrenture (Lanzhou) Biomedical Technology Co., Ltd
Tel
13919408782
Email
1297709337@qq.com
Country
China
ProdList
465
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 17801761073
Email
Gsiyu@solarbio.com
Country
China
ProdList
50464
Advantage
58
Shanghai Huasige Pharmaceutical Technology Co., LTD
Tel
13611612777
Email
3627377363@qq.com
Country
China
ProdList
4015
Advantage
58
Shanghai Tengjun Biotechnology Co. LTD
Tel
19821570922
Email
angela@labgogo.com
Country
China
ProdList
9896
Advantage
58
https://hanhongsci.com/
Tel
021-54306202 18917919676
Email
info@hanhongsci.com
Country
China
ProdList
29995
Advantage
58
Shandong Mopai Biotechnology Co., Ltd
Tel
13053322091
Email
admin@mopaikeji.com
Country
China
ProdList
5830
Advantage
58
Baoji Didu Pharmaceutical and Chemical Co., Ltd
Tel
029-81145305 17791533577
Email
1021@dideu.com
Country
China
ProdList
10009
Advantage
58
Shanghai Aladdin Biochemical Technology Co.,Ltd.
Tel
400-6206333 13167063860
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
48457
Advantage
58
Hangzhou Boloko Biotechnology Co., LTD
Tel
13757158499; 13757158499
Email
bolokobiotech@qq.com
Country
China
ProdList
3981
Advantage
58
More
Less

View Lastest Price from 5-(METHOXYCARBONYL)THIOPHENE-2-CARBOXYLIC ACID manufacturers

Career Henan Chemical Co
Product
5-(METHOXYCARBONYL)THIOPHENE-2-CARBOXYLIC ACID 50340-79-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-01-02

50340-79-9, 5-(METHOXYCARBONYL)THIOPHENE-2-CARBOXYLIC ACIDRelated Search:

Coumarin

  • 5-(METHOXYCARBONYL)THIOPHENE-2-CARBOXYLIC ACID
  • 2,5-Thiophenedicarboxylic acid, 2-methyl ester
  • 2,5-Thiophenedicarboxylicacid,monomethylester
  • 2-Methyl 2,5-thiophenedicarboxylate
  • 50340-79-9
  • C7H6SO4