5-(METHOXYCARBONYL)THIOPHENE-2-CARBOXYLIC ACID
- Product Name
- 5-(METHOXYCARBONYL)THIOPHENE-2-CARBOXYLIC ACID
- CAS No.
- 50340-79-9
- Chemical Name
- 5-(METHOXYCARBONYL)THIOPHENE-2-CARBOXYLIC ACID
- Synonyms
- 2-Methyl 2,5-thiophenedicarboxylate;2,5-Thiophenedicarboxylicacid,monomethylester;2,5-Thiophenedicarboxylic acid, 2-methyl ester;5-(METHOXYCARBONYL)THIOPHENE-2-CARBOXYLIC ACID
- CBNumber
- CB91491679
- Molecular Formula
- C7H6O4S
- Formula Weight
- 186.19
- MOL File
- 50340-79-9.mol
5-(METHOXYCARBONYL)THIOPHENE-2-CARBOXYLIC ACID Property
- Melting point:
- 187-190℃
- Boiling point:
- 365.2±27.0 °C(Predicted)
- Density
- 1.439±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 3.04±0.10(Predicted)
- Appearance
- White to yellow Solid
Safety
- Risk Statements
- 20/21/22
- Safety Statements
- 3/9-24/25-36/37
- HazardClass
- IRRITANT
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H320Causes eye irritation
H341Suspected of causing genetic defects
H350May cause cancer
H370Causes damage to organs
H373May cause damage to organs through prolonged or repeated exposure
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
P391Collect spillage. Hazardous to the aquatic environment
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M329865
- Product name
- 5-(Methoxycarbonyl)thiophene-2-carboxylicacid
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- M329865
- Product name
- 5-(Methoxycarbonyl)thiophene-2-carboxylicacid
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 008150
- Product name
- Thiophene-2,5-dicarboxylic acid monomethyl ester
- Purity
- 95+%
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 008150
- Product name
- Thiophene-2,5-dicarboxylic acid monomethyl ester
- Purity
- 95+%
- Packaging
- 5g
- Price
- $175
- Updated
- 2021/12/16
- Product number
- Z3443
- Product name
- Thiophene-2,5-dicarboxylicacidmonomethylester
- Packaging
- 5g
- Price
- $284
- Updated
- 2021/12/16
5-(METHOXYCARBONYL)THIOPHENE-2-CARBOXYLIC ACID Chemical Properties,Usage,Production
Chemical Properties
White solid
Synthesis
4282-34-2
50340-79-9
The general procedure for the synthesis of methyl 5-carboxylic acid-2-thiophenecarboxylate from dimethyl thiophene-2,5-dicarboxylate is as follows: to a mildly refluxed solution of dimethyl thiophene-2,5-dicarboxylate (0.430 g, 2.15 mmol) in dioxane/methanol (1:2, 1.5 ml) was added an aqueous sodium hydroxide solution (0.086 g, 2.15 mmol, dissolved in 0.5 ml of water). The reaction mixture was kept under stirring for 5 hours and subsequently cooled to room temperature. After adjusting the pH of the reaction solution to 2 with 1N hydrochloric acid, it was extracted with ethyl acetate (3 x 30 ml). The organic phases were combined, washed with brine (1 x 5 ml), dried over anhydrous magnesium sulfate and concentrated under reduced pressure to afford monomethyl thiophene-2,5-dicarboxylate as a white solid (0.342 g, 86% yield). The product was characterized by 1H NMR (CD3OD): δH 7.72-7.73 (d, 1H), 7.69-7.70 (d, 1H), 3.87 (s, 3H).
Structure and conformation
Thiophene-2,5-dicarboxylic acid monomethyl ester (TDCEM) has been shown to form dimers in solution. The crystal structure of TDCEM has been determined and found to be centrosymmetric with hydrogen bonds between the carbonyl oxygen atoms and the methyl groups on either side, as well as dihedral angles for the two methyl groups.
References
[1] Chemistry - A European Journal, 2016, vol. 22, # 33, p. 11785 - 11794
[2] Patent: US2004/2524, 2004, A1
[3] Patent: WO2004/817, 2003, A2. Location in patent: Page 99
[4] Patent: US2680731, 1950,
5-(METHOXYCARBONYL)THIOPHENE-2-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-(METHOXYCARBONYL)THIOPHENE-2-CARBOXYLIC ACID manufacturers
- Product
- 5-(METHOXYCARBONYL)THIOPHENE-2-CARBOXYLIC ACID 50340-79-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-02