6-Bromo-8-fluoroquinoline

Product Name: 6-Bromo-8-fluoroquinoline
CAS No.: 220513-46-2
Chemical Name: 6-Bromo-8-fluoroquinoline
Synonyms: 6-Bromo-8-fluoroquinoline;Quinoline, 6-bromo-8-fluoro-;6-Bromo-8-fluoroquinoline95%;6-Bromo-8-fluoroquinoline 95%;6-Bromo-8-fluoro-1-azanaphthalene;Cyclobutanecarboxylicacid,8-oxo-,phenylmethylester
CBNumber: CB91503246
Molecular Formula: C9H5BrFN
Formula Weight: 226.05
MOL File: 220513-46-2.mol

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6-Bromo-8-fluoroquinoline Property

Melting point:: 104-106°C
Boiling point:: 294.9±20.0 °C(Predicted)
Density: 1.647±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
form: crystalline powder
pka: 1.14±0.20(Predicted)
color: Pale yellow
InChI: InChI=1S/C9H5BrFN/c10-7-4-6-2-1-3-12-9(6)8(11)5-7/h1-5H
InChIKey: DDCOYWOYIUEOHQ-UHFFFAOYSA-N
SMILES: N1C2C(=CC(Br)=CC=2F)C=CC=1

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Safety

Hazard Codes: Xn
Risk Statements: 22-37/38-41
Safety Statements: 26-39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 772526
Product name: 6-Bromo-8-fluoroquinoline
Purity: 97%
Packaging: 500mg
Price: $72.8
Updated: 2023/06/20

TRC

Product number: B693423
Product name: 6-Bromo-8-fluoroquinoline
Packaging: 100mg
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: PC49040
Product name: 6-Bromo-8-fluoroquinoline
Purity: 95%
Packaging: 1g
Price: $40
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB78317
Product name: 6-Bromo-8-Fluoro-Quinoline
Packaging: 500mg
Price: $100
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB78317
Product name: 6-Bromo-8-Fluoro-Quinoline
Packaging: 1g
Price: $150
Updated: 2021/12/16

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6-Bromo-8-fluoroquinoline Chemical Properties,Usage,Production

Synthesis

367-24-8

56-81-5

220513-46-2

General procedure for the synthesis of 6-bromo-8-fluoroquinoline from 4-bromo-2-fluoroaniline and glycerol: 3-nitrobenzenesulfonic acid sodium salt (0.48 g, 2.132 mmol) and glycerol (0.516 ml, 7.06 mmol) were added to a concentrated H2SO4 (0.63 ml, 11.82 mmol) and H2O (0.48 ml, 26.6 mmol) solution to form a thick gray suspension. The mixture was heated to 110°C. 4-Bromo-2-fluoroaniline was added in batches over a period of 10 min, during which the temperature was raised to 95°C. The reaction mixture was then heated to 140 °C and stirred overnight. Upon completion of the reaction, the reaction mixture was cooled, poured into water and the pH was adjusted with ammonia to 7. The brown precipitate formed was collected by filtration and partially dried. The resulting solid (0.63 g) was purified by fast column chromatography to afford 6-bromo-8-fluoroquinoline (0.4 g, 1.77 mmol, 88% yield).

References

[1] Patent: WO2009/50204, 2009, A1. Location in patent: Page/Page column 15; 48-49
[2] Patent: WO2018/116072, 2018, A1. Location in patent: Page/Page column 97; 98
[3] Patent: CN105968115, 2016, A. Location in patent: Paragraph 0449-0451
[4] Patent: WO2010/20363, 2010, A1. Location in patent: Page/Page column 131-132
[5] Journal of Medicinal Chemistry, 2010, vol. 53, # 10, p. 4066 - 4084

6-Bromo-8-fluoroquinoline Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Bromo-8-fluoroquinoline Suppliers

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220513-46-2, 6-Bromo-8-fluoroquinolineRelated Search:

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6-Bromo-8-fluoroquinoline

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6-Bromo-8-fluoroquinoline 95%

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Cyclobutanecarboxylicacid,8-oxo-,phenylmethylester

220513-46-2