palovarotene
- Product Name
- palovarotene
- CAS No.
- 410528-02-8
- Chemical Name
- palovarotene
- Synonyms
- R 667;Ro 3300074;palovarotene;Unii-28K6I5m16g;R 667;RO 3300074;Ro 3300074|||R 667;Palovarotene(R 667);R667;R 667;R667;RO-3300074;RO 3300074;RO3300074;4-[(E)-2-[5,5,8,8-tetramethyl-3-(pyrazol-1-ylmethyl)-6,7-dihydronaphthalen-2-yl]ethenyl]benzoic acid;(E)-4-(2-(3-((1H-pyrazol-1-yl)Methyl)-5,5,8,8-tetraMethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid
- CBNumber
- CB91518527
- Molecular Formula
- C27H30N2O2
- Formula Weight
- 414.54
- MOL File
- 410528-02-8.mol
palovarotene Property
- Melting point:
- 249-252°C
- Boiling point:
- 592.3±50.0 °C(Predicted)
- Density
- 1.11
- storage temp.
- Refrigerator
- solubility
- DMSO (Slightly), Ethyl Acetate (Slightly, Heated), Methanol (Slightly, Heated)
- pka
- 4.26±0.10(Predicted)
- form
- Solid
- color
- White to Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 28460
- Product name
- Palovarotene
- Packaging
- 5mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 28460
- Product name
- Palovarotene
- Packaging
- 25mg
- Price
- $336
- Updated
- 2024/03/01
- Product number
- 28460
- Product name
- Palovarotene
- Packaging
- 10mg
- Price
- $152
- Updated
- 2024/03/01
- Product number
- P165900
- Product name
- Palovarotene
- Packaging
- 100mg
- Price
- $1455
- Updated
- 2021/12/16
- Product number
- CS-2031
- Product name
- Palovarotene
- Purity
- 99.49%
- Packaging
- 100mg
- Price
- $1600
- Updated
- 2021/12/16
palovarotene Chemical Properties,Usage,Production
Description
Palovarotene an orally bioavailable retinoic acid receptor γ (RARγ) agonist. It increases retinoic acid response element (RARE) activity and decreases NF-κB activity induced by IL-1β in primary mouse stromal cells in reporter assays when used at a concentration of 60 nM. Palovarotene (10 nM) inhibits activin A-induced chondrogenic and osteogenic differentiation of mouse fibro/adipogenic progenitors (FAPs) expressing a mutated form of human activin A receptor type I (ACVR1R206H). It inhibits heterotopic ossification and preserves limb movement and growth in a ACVR1R206H fibrodysplasia ossificans progressiva (FOP) mouse model. Palovarotene (1 mg/kg per day for 14 days) decreases heterotopic ossification by 50 to 60% in a rat model of traumatic blast injury.
Uses
Palovarotene, is a highly selective retinoic acid receptor gamma (RAR-γ) agonist that is under investigation as a potential treatment for emphysema.
Definition
ChEBI: Palovarotene is a stilbenoid.
palovarotene Preparation Products And Raw materials
Raw materials
Preparation Products
palovarotene Suppliers
- Tel
- --
- Fax
- --
- sales@alsachim.com
- Country
- France
- ProdList
- 424
- Advantage
- 0
View Lastest Price from palovarotene manufacturers
- Product
- Palovarotene 410528-02-8
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2020-01-10