palovarotene

Product Name: palovarotene
CAS No.: 410528-02-8
Chemical Name: palovarotene
Synonyms: R 667;Ro 3300074;palovarotene;Unii-28K6I5m16g;R 667;RO 3300074;Ro 3300074|||R 667;Palovarotene(R 667);R667;R 667;R667;RO-3300074;RO 3300074;RO3300074;4-[(E)-2-[5,5,8,8-tetramethyl-3-(pyrazol-1-ylmethyl)-6,7-dihydronaphthalen-2-yl]ethenyl]benzoic acid;(E)-4-(2-(3-((1H-pyrazol-1-yl)Methyl)-5,5,8,8-tetraMethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid
CBNumber: CB91518527
Molecular Formula: C27H30N2O2
Formula Weight: 414.54
MOL File: 410528-02-8.mol

More

Less

palovarotene Property

Melting point:: 249-252°C
Boiling point:: 592.3±50.0 °C(Predicted)
Density: 1.11
storage temp.: Refrigerator
solubility: DMSO (Slightly), Ethyl Acetate (Slightly, Heated), Methanol (Slightly, Heated)
pka: 4.26±0.10(Predicted)
form: Solid
color: White to Off-White

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 28460
Product name: Palovarotene
Packaging: 5mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 28460
Product name: Palovarotene
Packaging: 25mg
Price: $336
Updated: 2024/03/01

Cayman Chemical

Product number: 28460
Product name: Palovarotene
Packaging: 10mg
Price: $152
Updated: 2024/03/01

TRC

Product number: P165900
Product name: Palovarotene
Packaging: 100mg
Price: $1455
Updated: 2021/12/16

ApexBio Technology

Product number: B1175
Product name: Palovarotene
Packaging: 5mg
Price: $160
Updated: 2021/12/16

More

Less

palovarotene Chemical Properties,Usage,Production

Description

Palovarotene an orally bioavailable retinoic acid receptor γ (RARγ) agonist. It increases retinoic acid response element (RARE) activity and decreases NF-κB activity induced by IL-1β in primary mouse stromal cells in reporter assays when used at a concentration of 60 nM. Palovarotene (10 nM) inhibits activin A-induced chondrogenic and osteogenic differentiation of mouse fibro/adipogenic progenitors (FAPs) expressing a mutated form of human activin A receptor type I (ACVR1^R206H). It inhibits heterotopic ossification and preserves limb movement and growth in a ACVR1^R206H fibrodysplasia ossificans progressiva (FOP) mouse model. Palovarotene (1 mg/kg per day for 14 days) decreases heterotopic ossification by 50 to 60% in a rat model of traumatic blast injury.

Uses

Palovarotene, is a highly selective retinoic acid receptor gamma (RAR-γ) agonist that is under investigation as a potential treatment for emphysema.

Definition

ChEBI: Palovarotene is a stilbenoid.

palovarotene Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

palovarotene Suppliers

China 95 France 1 India 1 United States 12 Global 109

Chengdu Novel Biomedical Co., Ltd.

Tel: 028-85255396 18302801538
Fax: 028-85255396
Email: cdnovell@163.com
Country: China
ProdList: 2310
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94657
Advantage: 76

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Shanghai Fuhe Chemistry Technology Co., Ltd.

Tel: 0086-21-67651709
Fax: 0086-21-67651705
Email: cfx759@hotmail.com
Country: China
ProdList: 410
Advantage: 57

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Suzhou yacoo science co.,Ltd

Tel: 0512-87182056 18013166090
Fax: 0512-87182056
Email: lingling.qi@yacoo.com.cn
Country: China
ProdList: 7295
Advantage: 60

ShangHai KenEn Chemical Technology Co., Ltd.

Tel: 13120367189
Fax: 021-50315529
Email: mychess007@163.com
Country: China
ProdList: 1994
Advantage: 55

Tianjin Anhao Biological Technology Co., Ltd.

Tel
Email: sales@ahpharmatech.com
Country: China
ProdList: 5734
Advantage: 55

More

Less

View Lastest Price from palovarotene manufacturers

Career Henan Chemical Co

Product: Palovarotene 410528-02-8
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1ton
Release date: 2020-01-10

410528-02-8, palovaroteneRelated Search:

ANTI-ESTROGEN RECEPTOR Ethylamine (-)-Varitriol palovarotene 4-ISOPROPYL-1-METHYL-2-PROPENYLBENZENE 1-ISOPROPYL-4-(2-PHENYLVINYL)BENZENE (5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRONAPHTH-2-YL)METHYLAMINE

palovarotene

4-[(1E)-2-[5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-3-(1H-pyrazol-1-ylmethyl)-2-naphthalenyl]ethenyl]benzoic acid

Unii-28K6I5m16g

R 667

Ro 3300074

(E)-4-(2-(3-((1H-pyrazol-1-yl)Methyl)-5,5,8,8-tetraMethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid

Palovarotene(R 667)

R 667;RO 3300074

4-[(E)-2-[5,5,8,8-tetramethyl-3-(pyrazol-1-ylmethyl)-6,7-dihydronaphthalen-2-yl]ethenyl]benzoic acid

R667;R 667;R667;RO-3300074;RO 3300074;RO3300074

Benzoic acid, 4-[(1E)-2-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-(1H-pyrazol-1-ylmethyl)-2-naphthalenyl]ethenyl]-

Ro 3300074|||R 667

410528-02-8