6-AMINO-3,3-DIMETHYL-2-OXO-1,3-DIHYDRO-INDOLE

Product Name: 6-AMINO-3,3-DIMETHYL-2-OXO-1,3-DIHYDRO-INDOLE
CAS No.: 100510-65-4
Chemical Name: 6-AMINO-3,3-DIMETHYL-2-OXO-1,3-DIHYDRO-INDOLE
Synonyms: 6-Amino-3,3-dimethylindolin-2-one;AP3Impurity6;6-amino-3,3-dimethyl-1H-indol-2-one;6-Amino-3,3-dimethyl-1H-indolin-2-one;6-Amino-3,3-dimethyl-1,3-dihydro-indol-2-one;6-AMINO-3,3-DIMETHYL-2-OXO-1,3-DIHYDRO-INDOLE;6-Amino-1,2-dihydro-3,3-dimethyl-2-oxo-3H-indole;2H-Indol-2-one, 6-amino-1,3-dihydro-3,3-dimethyl-
CBNumber: CB91519625
Molecular Formula: C10H12N2O
Formula Weight: 176.22
MOL File: 100510-65-4.mol

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6-AMINO-3,3-DIMETHYL-2-OXO-1,3-DIHYDRO-INDOLE Property

Boiling point:: 366.6±42.0 °C(Predicted)
Density: 1.161±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 14.32±0.40(Predicted)
Appearance: Dark brown to black Solid

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Safety

Hazard Codes: Xn
Risk Statements: 22

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A605275
Product name: 6-Amino-3,3-dimethylindolin-2-one
Packaging: 50mg
Price: $180
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA142303
Product name: 6-Amino-3,3-dimethylindolin-2-one
Packaging: 100mg
Price: $250
Updated: 2021/12/16

Matrix Scientific

Product number: 145296
Product name: 6-Amino-3,3-dimethylindolin-2-one
Purity: 95%
Packaging: 250mg
Price: $304
Updated: 2021/12/16

AK Scientific

Product number: Z6285
Product name: 6-Amino-3,3-dimethylindolin-2-one
Packaging: 1g
Price: $384
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA142303
Product name: 6-Amino-3,3-dimethylindolin-2-one
Packaging: 250mg
Price: $400
Updated: 2021/12/16

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6-AMINO-3,3-DIMETHYL-2-OXO-1,3-DIHYDRO-INDOLE Chemical Properties,Usage,Production

Uses

6-Amino-3,3-dimethylindolin-2-one is a versatile reactant used in the preparation of selective and potent aminoisoquinoline derivatives as inhibitors of mutant B-Raf pathway. It is also used in the synthesis of pentacyclic aurora kinase inhibitors.

Synthesis

100510-64-3

100510-65-4

a) 3,3-Dimethyl-6-nitroindol-2-one (500 mg, 2.42 mmol) was dissolved in ethyl acetate (100 mL) and 10% palladium/activated carbon catalyst (129 mg, 121 μmol) was added. The reaction was stirred at 70 °C for 48 h under hydrogen atmosphere (balloon). After completion of the reaction, the catalyst was removed by filtration and the filtrate was washed with ethyl acetate. The filtrate was concentrated to give the orange powdery product 6-amino-3,3-dimethylindol-2-one (427 mg). The product was characterized by 1H NMR (DMSO-D6, 400 MHz): δ 10.75 (s, 1H), 7.92-7.89 (m, 1H), 7.62-7.58 (m, 2H), 1.30 (s, 6H).

References

[1] Patent: US2006/258689, 2006, A1. Location in patent: Page/Page column 35
[2] Patent: US4666923, 1987, A
[3] Patent: US2005/277643, 2005, A1
[4] Journal of Medicinal Chemistry, 2008, vol. 51, # 15, p. 4465 - 4475
[5] Patent: WO2014/40969, 2014, A1. Location in patent: Page/Page column 17

6-AMINO-3,3-DIMETHYL-2-OXO-1,3-DIHYDRO-INDOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-AMINO-3,3-DIMETHYL-2-OXO-1,3-DIHYDRO-INDOLE Suppliers

China 59 Germany 1 India 1 United Kingdom 1 United States 7 Global 69

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View Lastest Price from 6-AMINO-3,3-DIMETHYL-2-OXO-1,3-DIHYDRO-INDOLE manufacturers

Career Henan Chemical Co

Product: 6-AMINO-3,3-DIMETHYL-2-OXO-1,3-DIHYDRO-INDOLE 100510-65-4
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-11

100510-65-4, 6-AMINO-3,3-DIMETHYL-2-OXO-1,3-DIHYDRO-INDOLERelated Search:

6-AMINO-3,3-DIMETHYL-2,3-DIHYDRO-INDOLE 6-AMINO-3,3-DIMETHYL-2-OXO-1,3-DIHYDRO-INDOLE 2H-INDOL-2-ONE, 6-AMINO-1,3-DIHYDRO-

6-AMINO-3,3-DIMETHYL-2-OXO-1,3-DIHYDRO-INDOLE

6-Amino-3,3-dimethylindolin-2-one

6-Amino-1,2-dihydro-3,3-dimethyl-2-oxo-3H-indole

6-Amino-3,3-dimethyl-1H-indolin-2-one

6-amino-3,3-dimethyl-1H-indol-2-one

2H-Indol-2-one, 6-amino-1,3-dihydro-3,3-dimethyl-

6-Amino-3,3-dimethyl-1,3-dihydro-indol-2-one

AP3Impurity6

100510-65-4