1-benzofuran-3-carboxylic acid
- Product Name
- 1-benzofuran-3-carboxylic acid
- CAS No.
- 26537-68-8
- Chemical Name
- 1-benzofuran-3-carboxylic acid
- Synonyms
- 3-Carboxybenzo[b]furan;3-Benzofurancarboxylic acid;1-benzofuran-3-carboxylic acid;Benzo[b]furan-3-carboxylic acid;Benzo[b]furan-3-carboxylicacid97%;Benzo[b]furan-3-carboxylic acid 97%;1-benzofuran-3-carboxylic acid(SALTDATA: FREE);3-Carboxybenzo[b]furan, 1-Benzofuran-3-carboxylic acid
- CBNumber
- CB91543086
- Molecular Formula
- C9H6O3
- Formula Weight
- 162.14
- MOL File
- 26537-68-8.mol
1-benzofuran-3-carboxylic acid Property
- Melting point:
- 162℃
- Boiling point:
- 325.6±15.0 °C(Predicted)
- Density
- 1.363±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- pka
- 3.19±0.10(Predicted)
- color
- White
- InChI
- InChI=1S/C9H6O3/c10-9(11)7-5-12-8-4-2-1-3-6(7)8/h1-5H,(H,10,11)
- InChIKey
- BENJFDPHDCGUAQ-UHFFFAOYSA-N
- SMILES
- O1C2=CC=CC=C2C(C(O)=O)=C1
Safety
- HS Code
- 2932990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B427363
- Product name
- 1-benzofuran-3-carboxylicacid
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- OR16562
- Product name
- Benzo[b]furan-3-carboxylicacid
- Purity
- 97%
- Packaging
- 250mg
- Price
- $102
- Updated
- 2021/12/16
- Product number
- 2H21-1-X5
- Product name
- Benzo[b]furan-3-carboxylicacid
- Purity
- 97%
- Packaging
- 250mg
- Price
- $112
- Updated
- 2021/12/16
- Product number
- 011562
- Product name
- 1-Benzofuran-3-carboxylic acid
- Packaging
- 500mg
- Price
- $195
- Updated
- 2021/12/16
- Product number
- OR16562
- Product name
- Benzo[b]furan-3-carboxylicacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $232
- Updated
- 2021/12/16
1-benzofuran-3-carboxylic acid Chemical Properties,Usage,Production
Synthesis
40800-90-6
26537-68-8
The general procedure for the synthesis of benzofuran-3-carboxylic acid from 3-(methoxymethylenyl)-2(3H)-benzofuranone was as follows: 152 g of o-hydroxyphenylacetic acid was added to a reaction flask, 500 g of acetic anhydride and 250 g of trimethyl orthoformate were added. The temperature of the reaction mixture was raised to 80-100 °C and the temperature was maintained for 6 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure to give a yellow solid product. To this solid product, 500 g of methanol was added, stirred until completely dissolved, the temperature of the solution was controlled at 0-10 °C, and 180 g of 30% sodium hydroxide solution was slowly added dropwise. Subsequently, the reaction mixture was heated to 50-60°C and kept at this temperature for 3-6 hours. At the end of the reaction, methanol was recovered by distillation under reduced pressure. To the residue, 300 g of drinking water was added, the temperature of the solution was adjusted to below 30 °C, and 160 g of 30% hydrochloric acid was added slowly and dropwise to adjust the pH to 1-2. The mixture was cooled to 0-10 °C and allowed to stand for 3 hours for decantation. The precipitate was collected by filtration and the solid product was washed with cold water. Finally, the product was dried under vacuum to give 158 g of white solid benzofuran-3-carboxylic acid in 97.5% yield.
References
[1] Patent: CN108239054, 2018, A. Location in patent: Paragraph 0009; 0015; 0016; 0018; 0020; 0022; 0024
1-benzofuran-3-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-benzofuran-3-carboxylic acid manufacturers
- Product
- 1-benzofuran-3-carboxylic acid 26537-68-8
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-09