ChemicalBook > CAS DataBase List > 1H-PYRROLO[2,3-B]PYRIDINE-2,3-DIONE

1H-PYRROLO[2,3-B]PYRIDINE-2,3-DIONE

Product Name: 1H-PYRROLO[2,3-B]PYRIDINE-2,3-DIONE
CAS No.: 5654-95-5
Chemical Name: 1H-PYRROLO[2,3-B]PYRIDINE-2,3-DIONE
Synonyms: H-PYRROLO[2,3-B]PYRIDINE-2,3-DIONE;1H-PYRROLO[2,3-B]PYRIDINE-2,3-DIONE;1H-Pyrrolo[2,3-b]Pyrridine-2,3-dione;1H,2H,3H-pyrrolo[2,3-b]pyridine-2,3-dione
CBNumber: CB91556585
Molecular Formula: C7H4N2O2
Formula Weight: 148.12
MOL File: 5654-95-5.mol

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1H-PYRROLO[2,3-B]PYRIDINE-2,3-DIONE Property

Melting point:: 225-230 °C (decomp)
Boiling point:: 317.4±25.0 °C(Predicted)
Density: 1.60±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: -2.60±0.20(Predicted)
Appearance: Light yellow to brown Solid

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: P841033
Product name: 1H-Pyrrolo[2,3-B]pyridine-2,3-dione
Packaging: 10mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: Y5473
Product name: 1H-Pyrrolo[2,3-b]pyridine-2,3-dione
Packaging: 100mg
Price: $295
Updated: 2021/12/16

J&W Pharmlab

Product number: 69R1028
Product name: 1H-Pyrrolo[2,3-b]pyridine-2,3-dione
Purity: 97%
Packaging: 250mg
Price: $325
Updated: 2021/12/16

Chemenu

Product number: CM125631
Product name: 1H-pyrrolo[2,3-b]pyridine-2,3-dione
Purity: 95%+
Packaging: 1g
Price: $355
Updated: 2021/12/16

ACHEMBLOCK

Product number: P45467
Product name: 1H,2H,3H-pyrrolo[2,3-b]pyridine-2,3-dione
Purity: 97%
Packaging: 1G
Price: $475
Updated: 2021/12/16

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1H-PYRROLO[2,3-B]PYRIDINE-2,3-DIONE Chemical Properties,Usage,Production

Synthesis

5654-97-7

5654-95-5

General procedure for the synthesis of 1H-pyrrolo[2,3-b]pyridine-2,3-dione from 7-azaindol-2-one: Dry dimethylsulfoxide (DMSO, 6 mL) was heated to 120 °C, and 7-azaindol-2-one (500 mg, 3.7 mmol) and N-bromosuccinimide (NBS, 690.6 mg, 3.9 mmol) dissolved in a solution of anhydrous DMSO (2 mL). The reaction mixture was stirred at 120 °C for 30 min, and upon completion of the reaction, the pH was adjusted to 5-6 with 5% aqueous sodium bicarbonate (NaHCO3), followed by extraction with ethyl acetate. The organic phase was concentrated under reduced pressure to remove the solvent, and the resulting crude product was purified by column chromatography using ethyl acetate:hexane (3:1, v/v) as eluent to afford the target product 1H-pyrrolo[2,3-b]pyridine-2,3-dione (259.2 mg, 1.76 mmol, 65% yield) as a yellow solid. The structure of the product was characterized by nuclear magnetic resonance hydrogen spectroscopy (1H NMR, 400 MHz, DMSO-d6, δ= 2.49 ppm): 11.6 (s, 1H), 8.38 (dd, 1H, 3JH,H = 3.3 Hz, 4JH,H = 0.9 Hz), 7.87 (dd, 1H, 3JH,H = 5.0 Hz, 4JH,H = 1.1 Hz). 7.01 (dd, 1H, 3JH,H = 4.8 Hz, 4JH,H = 3.5 Hz) and NMR carbon spectra (13C-{1H} NMR, 150 MHz, DMSO-d6, δ= 39.5 ppm): 183.0, 164.0, 160.0, 155.2, 132.6, 119.0, 112.9 confirmed. Elemental analysis (C7H6N2O2): measured values C 56.66%, H 2.83%, N 18.72%; theoretical values C 56.76%, H 2.72%, N 18.91%.

References

[1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 1, p. 247 - 255
[2] Patent: EP2199292, 2010, A1. Location in patent: Page/Page column 10
[3] Helvetica Chimica Acta, 1941, vol. 24, p. 141E,145E,150E

1H-PYRROLO[2,3-B]PYRIDINE-2,3-DIONE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1H-PYRROLO[2,3-B]PYRIDINE-2,3-DIONE manufacturers

Career Henan Chemical Co

Product: 1H-PYRROLO[2,3-B]PYRIDINE-2,3-DIONE 5654-95-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-12-20

5654-95-5, 1H-PYRROLO[2,3-B]PYRIDINE-2,3-DIONERelated Search:

1H-PYRROLO[2,3-B]PYRIDINE-2,3-DIONE 1,3-DIHYDRO-2H-PYRROLO[2,3-B]PYRIDINE-2-ONE

1H-PYRROLO[2,3-B]PYRIDINE-2,3-DIONE

1H,2H,3H-pyrrolo[2,3-b]pyridine-2,3-dione

1H-Pyrrolo[2,3-b]Pyrridine-2,3-dione

H-PYRROLO[2,3-B]PYRIDINE-2,3-DIONE

5654-95-5