1H-PYRROLO[2,3-B]PYRIDINE-2,3-DIONE
- Product Name
- 1H-PYRROLO[2,3-B]PYRIDINE-2,3-DIONE
- CAS No.
- 5654-95-5
- Chemical Name
- 1H-PYRROLO[2,3-B]PYRIDINE-2,3-DIONE
- Synonyms
- H-PYRROLO[2,3-B]PYRIDINE-2,3-DIONE;1H-PYRROLO[2,3-B]PYRIDINE-2,3-DIONE;1H-Pyrrolo[2,3-b]Pyrridine-2,3-dione;1H,2H,3H-pyrrolo[2,3-b]pyridine-2,3-dione
- CBNumber
- CB91556585
- Molecular Formula
- C7H4N2O2
- Formula Weight
- 148.12
- MOL File
- 5654-95-5.mol
1H-PYRROLO[2,3-B]PYRIDINE-2,3-DIONE Property
- Melting point:
- 225-230 °C (decomp)
- Boiling point:
- 317.4±25.0 °C(Predicted)
- Density
- 1.60±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- -2.60±0.20(Predicted)
- Appearance
- Light yellow to brown Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- P841033
- Product name
- 1H-Pyrrolo[2,3-B]pyridine-2,3-dione
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- Y5473
- Product name
- 1H-Pyrrolo[2,3-b]pyridine-2,3-dione
- Packaging
- 100mg
- Price
- $295
- Updated
- 2021/12/16
- Product number
- 69R1028
- Product name
- 1H-Pyrrolo[2,3-b]pyridine-2,3-dione
- Purity
- 97%
- Packaging
- 250mg
- Price
- $325
- Updated
- 2021/12/16
- Product number
- CM125631
- Product name
- 1H-pyrrolo[2,3-b]pyridine-2,3-dione
- Purity
- 95%+
- Packaging
- 1g
- Price
- $355
- Updated
- 2021/12/16
- Product number
- P45467
- Product name
- 1H,2H,3H-pyrrolo[2,3-b]pyridine-2,3-dione
- Purity
- 97%
- Packaging
- 1G
- Price
- $475
- Updated
- 2021/12/16
1H-PYRROLO[2,3-B]PYRIDINE-2,3-DIONE Chemical Properties,Usage,Production
Synthesis
5654-97-7
5654-95-5
General procedure for the synthesis of 1H-pyrrolo[2,3-b]pyridine-2,3-dione from 7-azaindol-2-one: Dry dimethylsulfoxide (DMSO, 6 mL) was heated to 120 °C, and 7-azaindol-2-one (500 mg, 3.7 mmol) and N-bromosuccinimide (NBS, 690.6 mg, 3.9 mmol) dissolved in a solution of anhydrous DMSO (2 mL). The reaction mixture was stirred at 120 °C for 30 min, and upon completion of the reaction, the pH was adjusted to 5-6 with 5% aqueous sodium bicarbonate (NaHCO3), followed by extraction with ethyl acetate. The organic phase was concentrated under reduced pressure to remove the solvent, and the resulting crude product was purified by column chromatography using ethyl acetate:hexane (3:1, v/v) as eluent to afford the target product 1H-pyrrolo[2,3-b]pyridine-2,3-dione (259.2 mg, 1.76 mmol, 65% yield) as a yellow solid. The structure of the product was characterized by nuclear magnetic resonance hydrogen spectroscopy (1H NMR, 400 MHz, DMSO-d6, δ= 2.49 ppm): 11.6 (s, 1H), 8.38 (dd, 1H, 3JH,H = 3.3 Hz, 4JH,H = 0.9 Hz), 7.87 (dd, 1H, 3JH,H = 5.0 Hz, 4JH,H = 1.1 Hz). 7.01 (dd, 1H, 3JH,H = 4.8 Hz, 4JH,H = 3.5 Hz) and NMR carbon spectra (13C-{1H} NMR, 150 MHz, DMSO-d6, δ= 39.5 ppm): 183.0, 164.0, 160.0, 155.2, 132.6, 119.0, 112.9 confirmed. Elemental analysis (C7H6N2O2): measured values C 56.66%, H 2.83%, N 18.72%; theoretical values C 56.76%, H 2.72%, N 18.91%.
References
[1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 1, p. 247 - 255
[2] Patent: EP2199292, 2010, A1. Location in patent: Page/Page column 10
[3] Helvetica Chimica Acta, 1941, vol. 24, p. 141E,145E,150E
1H-PYRROLO[2,3-B]PYRIDINE-2,3-DIONE Preparation Products And Raw materials
Raw materials
Preparation Products
1H-PYRROLO[2,3-B]PYRIDINE-2,3-DIONE Suppliers
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View Lastest Price from 1H-PYRROLO[2,3-B]PYRIDINE-2,3-DIONE manufacturers
- Product
- 1H-PYRROLO[2,3-B]PYRIDINE-2,3-DIONE 5654-95-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-20