2-bromo-5-nitrobenzaldehyde
- Product Name
- 2-bromo-5-nitrobenzaldehyde
- CAS No.
- 84459-32-5
- Chemical Name
- 2-bromo-5-nitrobenzaldehyde
- Synonyms
- 2-Bromo-5-nitrobenzadehyde;2-bromo-5-nitrobenzaldehyde;4-Bromo-3-formylnitrobenzene;Benzaldehyde, 2-bromo-5-nitro-;2-Bromo-5-nitrobenzenecarbaldehyde
- CBNumber
- CB91557739
- Molecular Formula
- C7H4BrNO3
- Formula Weight
- 230.02
- MOL File
- 84459-32-5.mol
2-bromo-5-nitrobenzaldehyde Property
- Melting point:
- 105-107 °C
- Boiling point:
- 307.2±27.0 °C(Predicted)
- Density
- 1.781
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- solid
- color
- White to off-white
Safety
- HazardClass
- IRRITANT
- HS Code
- 2913000090
N-Bromosuccinimide Price
- Product number
- B699668
- Product name
- 2-Bromo-5-nitrobenzaldehyde
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 046941
- Product name
- 2-Bromo-5-nitrobenzaldehyde
- Purity
- 95+%
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
- Product number
- OR16898
- Product name
- 2-Bromo-5-nitrobenzaldehyde
- Purity
- 98%
- Packaging
- 5g
- Price
- $40
- Updated
- 2021/12/16
- Product number
- 4654-9-X5
- Product name
- 2-Bromo-5-nitrobenzaldehyde
- Packaging
- 5G
- Price
- $44
- Updated
- 2021/12/16
- Product number
- X0174
- Product name
- 2-Bromo-5-nitrobenzaldehyde
- Packaging
- 5g
- Price
- $45
- Updated
- 2021/12/16
2-bromo-5-nitrobenzaldehyde Chemical Properties,Usage,Production
Uses
2-Bromo-5-nitrobenzaldehyde is a cholesteryl ester transfer protein (CETP) inhibitor. 2-Bromo-5-nitrobenzaldehyde is a commonly used reactant for the synthesis of (-)-Linarinic acid derivatives as neuroprotective agents against oxygen glucose deprivation (OGD)-?induced cell damage.
Synthesis
6630-33-7
84459-32-5
2-Bromobenzaldehyde (10.0 g, 53.7 mmol) was dissolved in concentrated sulfuric acid (100 mL) at 0 °C. Potassium nitrate (5.43 g, 53.7 mmol) was added in batches over 1 h at this temperature. After addition, the reaction mixture was continued to be stirred for 40 min, followed by the addition of potassium nitrate (0.72 g). The reaction temperature was maintained at 0°C and stirring was continued for 3 hours. After completion of the reaction, the mixture was slowly poured into ice water. The precipitate precipitated was collected by filtration, washed well with water and finally recrystallized with ethyl acetate/pentane mixed solvent to give 2-bromo-5-nitrobenzaldehyde (11.7 g, 94% yield) as a white solid. The mass spectrometry (ESI) analysis was consistent with the theoretical value of C7H4BrNO3 (228.9).
References
[1] Patent: WO2014/186313, 2014, A1. Location in patent: Page/Page column 173-174
[2] Patent: US2015/152108, 2015, A1. Location in patent: Paragraph 0881; 0882
[3] Tetrahedron Letters, 2016, vol. 57, # 1, p. 11 - 14
[4] Organic and Biomolecular Chemistry, 2017, vol. 15, # 6, p. 1355 - 1362
[5] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 20, p. 5051 - 5057
2-bromo-5-nitrobenzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
2-bromo-5-nitrobenzaldehyde Suppliers
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View Lastest Price from 2-bromo-5-nitrobenzaldehyde manufacturers
- Product
- 2-Bromo-5-nitrobenzenecarbaldehyde 84459-32-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.0%
- Supply Ability
- 100 tons
- Release date
- 2022-01-14
- Product
- 2-bromo-5-nitrobenzaldehyde 84459-32-5
- Price
- US $5.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2019-08-05