4-(bromomethyl)-1-chloro-2-methoxybenzene
- Product Name
- 4-(bromomethyl)-1-chloro-2-methoxybenzene
- CAS No.
- 103347-14-4
- Chemical Name
- 4-(bromomethyl)-1-chloro-2-methoxybenzene
- Synonyms
- 4-Chloro-3-Methoxybenzyl broMide;4-(bromomethyl)-1-chloro-2-methoxybenzene;Benzene, 4-(bromomethyl)-1-chloro-2-methoxy-
- CBNumber
- CB91559177
- Molecular Formula
- C8H8BrClO
- Formula Weight
- 235.51
- MOL File
- 103347-14-4.mol
4-(bromomethyl)-1-chloro-2-methoxybenzene Property
- Boiling point:
- 115 °C(Press: 0.4 Torr)
- Density
- 1.520±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Dichloromethane, Ethyl Acetate
- form
- Oil
- color
- Pale Yellow
Safety
- HS Code
- 2909309090
N-Bromosuccinimide Price
- Product number
- B688590
- Product name
- 4-(Bromomethyl)-1-chloro-2-methoxybenzene
- Packaging
- 500mg
- Price
- $340
- Updated
- 2021/12/16
- Product number
- HCH0358573
- Product name
- 4-(BROMOMETHYL)-1-CHLORO-2-METHOXYBENZENE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.11
- Updated
- 2021/12/16
- Product number
- 116364
- Product name
- 4-(Bromomethyl)-1-chloro-2-methoxybenzene
- Purity
- >97%
- Packaging
- 500mg
- Price
- $544
- Updated
- 2021/12/16
- Product number
- OR310902
- Product name
- 4-Chloro-3-methoxybenzylbromide
- Packaging
- 250mg
- Price
- $288
- Updated
- 2021/12/16
- Product number
- 2707-D-02
- Product name
- 4-(Bromomethyl)-1-chloro-2-methoxybenzene
- Packaging
- 250mg
- Price
- $317
- Updated
- 2021/12/16
4-(bromomethyl)-1-chloro-2-methoxybenzene Chemical Properties,Usage,Production
Uses
4-(Bromomethyl)-1-chloro-2-methoxybenzene is an intermediate in the synthesis of 5-(3-((1H-1,2,4-Triazol-1-yl)methyl)-3-hydroxy-4,4-dimethylpentyl)-2-chlorophenol (T767575), which is a tebuconazole impurity. Tebuconazole (T013000) is an ergosterol biosynthesis inhibitor. Fungicide.
Synthesis
73909-16-7
103347-14-4
General procedure for the synthesis of 4-(bromomethyl)-1-chloro-2-methoxybenzene from 1-chloro-2-methoxy-4-methylbenzene: to a solution of 1-chloro-2-methoxy-4-methylbenzene (274 g, 1.75 mol) in dichloromethane (2.5 L) was added benzoyl peroxide (4.23 g, 0.02 mol) and N-bromosuccinimide (NBS. 321 g, 1.80 mol). The reaction mixture was heated to reflux for 1 h under mechanical stirring. After completion of the reaction, the reaction mixture was cooled, washed sequentially with 1N hydrochloric acid (2L), saturated sodium bicarbonate solution (2L) and brine (2L), dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford 4-(bromomethyl)-1-chloro-2-methoxybenzene as a pale yellow solid (412 g, quantitative yield).1H NMR (400 MHz, CDCl3): δ7.30- 7.34 (d, 1H), 6.95 (s, 1H), 6.91-6.93 (d, 1H), 4.45 (s, 2H), 3.92 (s, 3H).
References
[1] Patent: WO2011/71565, 2011, A1. Location in patent: Page/Page column 145-146
[2] Patent: WO2010/93845, 2010, A1. Location in patent: Page/Page column 136-137
[3] Patent: US6984657, 2006, B1
[4] Patent: US2007/244159, 2007, A1. Location in patent: Page/Page column 91
[5] Patent: US2011/98311, 2011, A1
4-(bromomethyl)-1-chloro-2-methoxybenzene Preparation Products And Raw materials
Raw materials
Preparation Products
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