8-methylquinazoline-2,4(1H,3H)-dione

Product Name: 8-methylquinazoline-2,4(1H,3H)-dione
CAS No.: 67449-23-4
Chemical Name: 8-methylquinazoline-2,4(1H,3H)-dione
Synonyms: 8-methylquinazoline-2,4-diol;2,4-Dihydroxy-8-methylquinazoline;8-methyl-1H-quinazoline-2,4-dione;8-methylquinazoline-2,4(1H,3H)-dione;2,4(1H,3H)-Quinazolinedione, 8-methyl-;8-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline;8-Methyl-1,2,3,4-tetrahydroquinazoline-2,4-dione
CBNumber: CB91560405
Molecular Formula: C9H8N2O2
Formula Weight: 176.17
MOL File: 67449-23-4.mol

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8-methylquinazoline-2,4(1H,3H)-dione Property

Melting point:: 283 °C
Density: 1.280±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 11.13±0.20(Predicted)
Appearance: Off-white to light yellow Solid

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-W001030
Product name: 8-methylquinazoline-2,4-diol
Packaging: 1g
Price: $89
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H48-1-MW
Product name: 8-Methyl-1,2,3,4-tetrahydroquinazoline-2,4-dione
Packaging: 1g
Price: $199
Updated: 2021/12/16

ChemScene

Product number: CS-W001030
Product name: 8-methylquinazoline-2,4-diol
Packaging: 5g
Price: $277
Updated: 2021/12/16

ChemScene

Product number: CS-W001030
Product name: 8-methylquinazoline-2,4-diol
Packaging: 10g
Price: $472
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0101832
Product name: 8-METHYLQUINAZOLINE-2,4(1H,3H)-DIONE
Purity: 95.00%
Packaging: 5MG
Price: $498.49
Updated: 2021/12/16

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8-methylquinazoline-2,4(1H,3H)-dione Chemical Properties,Usage,Production

Synthesis

4389-45-1

57-13-6

67449-23-4

GENERAL METHOD: 2-Amino-3-methylbenzoic acid (5.0 g, 33.1 mmol) was mixed with urea (20 g) and the reaction was stirred at 160°C for 6 hours. Upon completion of the reaction, the reaction mixture was cooled to 100 °C and an equal volume of water was slowly added with continuous stirring for 5 min. Subsequently, the precipitate formed was collected by filtration and washed with cold water to obtain a solid filter cake. This filter cake was suspended in 0.5 N NaOH aqueous solution, heated to boiling and held for 5 minutes, then cooled to room temperature. The pH of the suspension was adjusted to 2 with concentrated hydrochloric acid and the quinazoline dione product was collected by filtration. The product was washed with a mixture of water: methanol (1:1) and dried under vacuum to give 4.50 g (25.5 mmol, 77% yield) of 2,4-dihydroxy-8-methylquinazoline solid. The 1H-NMR (CDCl3) data of the product were as follows: δ (ppm) 7.78-7.74 (m, 1H), 7.49-7.46 (m, 1H), 7.11-7.05 (m, 1H), 2.31 (s, 3H).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 1, p. 461 - 467
[2] Synthesis (Germany), 2016, vol. 48, # 8, p. 1226 - 1234
[3] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 3, p. 254 - 259
[4] Journal of Medicinal Chemistry, 2014, vol. 57, # 12, p. 5141 - 5156
[5] Patent: US2016/90374, 2016, A1. Location in patent: Paragraph 0170; 0171

8-methylquinazoline-2,4(1H,3H)-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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8-methylquinazoline-2,4(1H,3H)-dione Suppliers

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67449-23-4, 8-methylquinazoline-2,4(1H,3H)-dioneRelated Search:

8-methylquinazoline-2,4(1H,3H)-dione

2,4(1H,3H)-Quinazolinedione, 8-methyl-

8-methylquinazoline-2,4-diol

8-methyl-1H-quinazoline-2,4-dione

8-Methyl-1,2,3,4-tetrahydroquinazoline-2,4-dione

8-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline

2,4-Dihydroxy-8-methylquinazoline

67449-23-4