8-methylquinazoline-2,4(1H,3H)-dione
- Product Name
- 8-methylquinazoline-2,4(1H,3H)-dione
- CAS No.
- 67449-23-4
- Chemical Name
- 8-methylquinazoline-2,4(1H,3H)-dione
- Synonyms
- 8-methylquinazoline-2,4-diol;2,4-Dihydroxy-8-methylquinazoline;8-methyl-1H-quinazoline-2,4-dione;8-methylquinazoline-2,4(1H,3H)-dione;2,4(1H,3H)-Quinazolinedione, 8-methyl-;8-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline;8-Methyl-1,2,3,4-tetrahydroquinazoline-2,4-dione
- CBNumber
- CB91560405
- Molecular Formula
- C9H8N2O2
- Formula Weight
- 176.17
- MOL File
- 67449-23-4.mol
8-methylquinazoline-2,4(1H,3H)-dione Property
- Melting point:
- 283 °C
- Density
- 1.280±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 11.13±0.20(Predicted)
- Appearance
- Off-white to light yellow Solid
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-W001030
- Product name
- 8-methylquinazoline-2,4-diol
- Packaging
- 1g
- Price
- $89
- Updated
- 2021/12/16
- Product number
- 4H48-1-MW
- Product name
- 8-Methyl-1,2,3,4-tetrahydroquinazoline-2,4-dione
- Packaging
- 1g
- Price
- $199
- Updated
- 2021/12/16
- Product number
- CS-W001030
- Product name
- 8-methylquinazoline-2,4-diol
- Packaging
- 5g
- Price
- $277
- Updated
- 2021/12/16
- Product number
- CS-W001030
- Product name
- 8-methylquinazoline-2,4-diol
- Packaging
- 10g
- Price
- $472
- Updated
- 2021/12/16
- Product number
- CHM0101832
- Product name
- 8-METHYLQUINAZOLINE-2,4(1H,3H)-DIONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.49
- Updated
- 2021/12/16
8-methylquinazoline-2,4(1H,3H)-dione Chemical Properties,Usage,Production
Synthesis
4389-45-1
57-13-6
67449-23-4
GENERAL METHOD: 2-Amino-3-methylbenzoic acid (5.0 g, 33.1 mmol) was mixed with urea (20 g) and the reaction was stirred at 160°C for 6 hours. Upon completion of the reaction, the reaction mixture was cooled to 100 °C and an equal volume of water was slowly added with continuous stirring for 5 min. Subsequently, the precipitate formed was collected by filtration and washed with cold water to obtain a solid filter cake. This filter cake was suspended in 0.5 N NaOH aqueous solution, heated to boiling and held for 5 minutes, then cooled to room temperature. The pH of the suspension was adjusted to 2 with concentrated hydrochloric acid and the quinazoline dione product was collected by filtration. The product was washed with a mixture of water: methanol (1:1) and dried under vacuum to give 4.50 g (25.5 mmol, 77% yield) of 2,4-dihydroxy-8-methylquinazoline solid. The 1H-NMR (CDCl3) data of the product were as follows: δ (ppm) 7.78-7.74 (m, 1H), 7.49-7.46 (m, 1H), 7.11-7.05 (m, 1H), 2.31 (s, 3H).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 1, p. 461 - 467
[2] Synthesis (Germany), 2016, vol. 48, # 8, p. 1226 - 1234
[3] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 3, p. 254 - 259
[4] Journal of Medicinal Chemistry, 2014, vol. 57, # 12, p. 5141 - 5156
[5] Patent: US2016/90374, 2016, A1. Location in patent: Paragraph 0170; 0171
8-methylquinazoline-2,4(1H,3H)-dione Preparation Products And Raw materials
Raw materials
Preparation Products
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