Methyl L-leucinate hydrochloride
- Product Name
- Methyl L-leucinate hydrochloride
- CAS No.
- 7517-19-3
- Chemical Name
- Methyl L-leucinate hydrochloride
- Synonyms
- H-Leu-OMe;(S)-Methyl 2-aMino-4-Methylpentanoate hydrochloride;H-LEU-OME·HCL;L-LEUCINE METHYL ESTER HCL;LEUCINE METHYL ESTER HYDROCHLORIDE;L-LEUCINE METHYL ESTER HYDROCHLORIDE;TYRO-002;L-Leu-OMe.HCL;H-LEU-OME HCL;eucine MethyL
- CBNumber
- CB9160343
- Molecular Formula
- C7H16ClNO2
- Formula Weight
- 181.66
- MOL File
- 7517-19-3.mol
Methyl L-leucinate hydrochloride Property
- Melting point:
- 151-153 °C(lit.)
- alpha
- 20 º (c=4.5, MeOH)
- refractive index
- 13 ° (C=2, H2O)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- H2O: 50 mg/mL, clear, colorless
- form
- Crystals or Crystalline Powder
- color
- White
- optical activity
- [α]22/D +13°, c = 2 in H2O
- Water Solubility
- soluble
- Sensitive
- Hygroscopic
- BRN
- 3595133
- InChI
- InChI=1/C7H15NO2.ClH/c1-5(2)4-6(8)7(9)10-3;/h5-6H,4,8H2,1-3H3;1H/t6-;/s3
- InChIKey
- DODCBMODXGJOKD-UZHXKHNSNA-N
- SMILES
- [C@H](N)(CC(C)C)C(=O)OC.Cl |&1:0,r|
- CAS DataBase Reference
- 7517-19-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 22-24/25-36/37/39-27-26
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29224995
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- L1002
- Product name
- L-Leucine methyl ester hydrochloride
- Purity
- 98%
- Packaging
- 10G
- Price
- $41.5
- Updated
- 2025/07/31
- Product number
- L1002
- Product name
- L-Leucine methyl ester hydrochloride
- Purity
- 98%
- Packaging
- 25G
- Price
- $88.9
- Updated
- 2025/07/31
- Product number
- L0155
- Product name
- L-Leucine Methyl Ester Hydrochloride
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $65
- Updated
- 2025/07/31
- Product number
- L330155
- Product name
- L-Leucine methyl ester hydrochloride
- Packaging
- 250g
- Price
- $725
- Updated
- 2021/12/16
- Product number
- JK251999
- Product name
- H-Leu-OMe?HCl
- Purity
- 99%
- Packaging
- 5g
- Price
- $13
- Updated
- 2021/12/16
Methyl L-leucinate hydrochloride Chemical Properties,Usage,Production
Chemical Properties
Crystalline
Uses
L-Leucine methyl ester is a protected form of L-Leucine (L330110). L-Leucine is an essential amino acid that induces a sharp decrease in blood glucose levels in individuals with idiopathic familial hypoglycemia, but has no known effects on normal, healthy individuals. L-Leucine also acts as an Isoleucine (I820210) antagonist in the rat, causing delays in growth, and is a potential tumour promoter of bladder cancer.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
67-56-1
61-90-5
7517-19-3
Under ice bath conditions, 60 mL of methanol was added to a 100 mL round bottom flask. 4 mL of sulfoxide chloride (SOCl2) was added slowly and dropwise through a constant pressure dropping funnel (with a drying tube fitted at the top), while the resulting off-gas was absorbed using NaOH solution. After stirring the reaction mixture for 1 h, 8 mmol of L-leucine was added and stirring was continued for 30 min at room temperature. Subsequently, the reaction system was warmed up to 66 °C and the reaction was refluxed for 6 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) with an ethanol solution of 2% ninhydrin as the color developer until the raw material spot disappeared. After completion of the reaction, the solvent was removed by distillation under reduced pressure to give L-leucine methyl ester hydrochloride in 100% yield.
References
[1] Patent: US2014/206741, 2014, A1. Location in patent: Paragraph 0121
[2] Journal of Organic Chemistry, 2003, vol. 68, # 12, p. 5006 - 5008
[3] Synthetic Communications, 2010, vol. 40, # 8, p. 1161 - 1179
[4] Bulletin des Societes Chimiques Belges, 1991, vol. 100, # 1, p. 63 - 77
[5] Chemical Biology and Drug Design, 2012, vol. 79, # 2, p. 216 - 222
Methyl L-leucinate hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl L-leucinate hydrochloride Suppliers
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- Fax
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- chemcontrol@nextra.sk
- Country
- Slovakia
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View Lastest Price from Methyl L-leucinate hydrochloride manufacturers
- Product
- Methyl L-leucinate hydrochloride 7517-19-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.5～101.5%,USP
- Supply Ability
- 20tons/month
- Release date
- 2021-06-23
- Product
- L-Leu-OMe.HCl 7517-19-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2024-03-24
- Product
- Methyl L-leucinate hydrochloride 7517-19-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-17