TERT-BUTYL 6-HYDROXY-3,4-DIHYDROQUINOLINE-1(2H)-CARBOXYLATE
- Product Name
- TERT-BUTYL 6-HYDROXY-3,4-DIHYDROQUINOLINE-1(2H)-CARBOXYLATE
- CAS No.
- 327044-56-4
- Chemical Name
- TERT-BUTYL 6-HYDROXY-3,4-DIHYDROQUINOLINE-1(2H)-CARBOXYLATE
- Synonyms
- 1-Boc-1,2,3,4-tetrahydroquinolin-6-ol;tert-Butyl 6-hydroxy-3,4-dihydroquinoline-1(2H);tert-butyl 6-hydroxy-3,4-dihydro-2H-quinoline-1-carboxyla;TERT-BUTYL 6-HYDROXY-3,4-DIHYDROQUINOLINE-1(2H)-CARBOXYLATE;tert-butyl 6-hydroxy-3,4-dihydro-2H-quinoline-1-carboxylate;6-Hydroxy-3,4-dihydro-2H-quinoline-1-carboxylic acid tert-butyl ester;tert-butyl 6-hydroxy-3,4-dihydro-2H-quinoline-1-carboxylate - [AC78343];1 (2H)-QUINOLINECARBOXYLIC ACID, 3,4-DIHYDRO-6-HYDROXY-,1,1-DIMETHYLETHYL ESTER
- CBNumber
- CB9165050
- Molecular Formula
- C14H19NO3
- Formula Weight
- 249.31
- MOL File
- 327044-56-4.mol
TERT-BUTYL 6-HYDROXY-3,4-DIHYDROQUINOLINE-1(2H)-CARBOXYLATE Property
- Boiling point:
- 400.0±41.0 °C(Predicted)
- Density
- 1.170±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 10.44±0.20(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P000643398
- Product name
- tert-Butyl 6-hydroxy-3,4-dihydroquinoline-1(2H)-carboxylate
- Purity
- 98%
- Packaging
- 100mg
- Price
- $79
- Updated
- 2021/12/16
- Product number
- 4624AJ
- Product name
- tert-Butyl6-hydroxy-3,4-dihydroquinoline-1(2H)-carboxylate
- Packaging
- 100mg
- Price
- $149
- Updated
- 2021/12/16
- Product number
- P000643398
- Product name
- tert-Butyl 6-hydroxy-3,4-dihydroquinoline-1(2H)-carboxylate
- Purity
- 98%
- Packaging
- 250mg
- Price
- $157
- Updated
- 2021/12/16
- Product number
- P000643398
- Product name
- tert-Butyl 6-hydroxy-3,4-dihydroquinoline-1(2H)-carboxylate
- Purity
- 98%
- Packaging
- 1g
- Price
- $393
- Updated
- 2021/12/16
- Product number
- CHM0379647
- Product name
- TERT-BUTYL-6-HYDROXY-3,4-DIHYDROQUINOLINE-1-(2H)-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.3
- Updated
- 2021/12/16
TERT-BUTYL 6-HYDROXY-3,4-DIHYDROQUINOLINE-1(2H)-CARBOXYLATE Chemical Properties,Usage,Production
Synthesis
3373-00-0
24424-99-5
327044-56-4
Method E: 6-Hydroxy-1,2,3,4-tetrahydroquinoline (25 g, 172.9 mmol) was dissolved in a solvent mixture of dioxane (200 mL) and 1N NaOH aqueous solution (200 mL), followed by addition of di-tert-butyl dicarbonate (56.6 g, 259.4 mmol). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the organic and aqueous layers were separated and the aqueous layer was extracted with ethyl acetate (2 x 200 mL). The organic layers were combined, washed with saturated saline (1 × 200 mL) and dried over anhydrous sodium sulfate. The organic layer was concentrated under reduced pressure to give the crude product. The target product tert-butyl 6-hydroxy-3,4-dihydro-2H-quinoline-1-carboxylate (33.0 g, 76.7% yield) was purified by fast column chromatography (Biotage system, eluent: 10% ethyl acetate/hexane).
References
[1] Patent: WO2004/26837, 2004, A2. Location in patent: Page 17-18
[2] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 13, p. 3415 - 3418
[3] Patent: WO2009/87649, 2009, A1. Location in patent: Page/Page column 25; 26
TERT-BUTYL 6-HYDROXY-3,4-DIHYDROQUINOLINE-1(2H)-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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