4-N-BOC-AMINOPHENOL

Product Name: 4-N-BOC-AMINOPHENOL
CAS No.: 54840-15-2
Chemical Name: 4-N-BOC-AMINOPHENOL
Synonyms: 4-N-BOC-AMINOPHENOL;4-(BOC-AMINO)PHENOL;N-BOC-4-HYDROXY ANILINE;N-Boc-4-hydroxyaniline 97%;N-Boc-4-hydroxyaniline,95%;N-Boc-4-hydroxyaniline;tert-Butyl p-hydroxycarbanilate;tert-butyl 4-hydroxyphenylcarbamate;tert-Butyl N-(4-hydroxyphenyl)carbamate;1,1-DiMethylethyl (4-hydroxyphenyl)carbaMate
CBNumber: CB9246409
Molecular Formula: C11H15NO3
Formula Weight: 209.24
MOL File: 54840-15-2.mol

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4-N-BOC-AMINOPHENOL Property

Melting point:: 143-147 °C(lit.)
Boiling point:: 288.7±23.0 °C(Predicted)
Density: 1.182±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 10.13±0.26(Predicted)
Appearance: White to off-white Solid
Water Solubility: Slightly soluble in water.
InChI: InChI=1S/C11H15NO3/c1-11(2,3)15-10(14)12-8-4-6-9(13)7-5-8/h4-7,13H,1-3H3,(H,12,14)
InChIKey: YRQMBQUMJFVZLF-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)NC1=CC=C(O)C=C1
CAS DataBase Reference: 54840-15-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-43
Safety Statements: 26-36-36/37
WGK Germany: 3
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 576646
Product name: N-Boc-4-hydroxyaniline
Purity: 97%
Packaging: 5g
Price: $41.9
Updated: 2025/07/31

Sigma-Aldrich

Product number: 576646
Product name: N-Boc-4-hydroxyaniline
Purity: 97%
Packaging: 25g
Price: $105
Updated: 2025/07/31

TRC

Product number: B619665
Product name: 4-N-Boc-Aminophenol
Packaging: 500mg
Price: $75
Updated: 2021/12/16

Oakwood

Product number: 011552
Product name: 4-N-Boc-aminophenol
Purity: 98%
Packaging: 1g
Price: $10
Updated: 2021/12/16

Matrix Scientific

Product number: 037024
Product name: tert-Butyl 4-hydroxyphenylcarbamate
Packaging: 1g
Price: $10
Updated: 2021/12/16

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4-N-BOC-AMINOPHENOL Chemical Properties,Usage,Production

Uses

4-(Boc-amino)phenol, is used to protect amine in the solid phase synthesis of peptides, used to produce [4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-carbamic acid tert-butyl ester at ambient temperature. This reaction will need reagent imidazole and solvent dimethylformamide, CH2Cl2.

Synthesis

24424-99-5

123-30-8

54840-15-2

General procedure for the synthesis of oxycarbonyloxy-4-hydroxyaniline from di-tert-butyl dicarbonate and 4-aminophenol: Di-tert-butyl dicarbonate (24.07 g, 110.3 mmol) was slowly added to a methanol (200 mL) solution containing 4-aminophenol (10.97 g, 100.5 mmol) and triethylamine (30 mL). The reaction mixture was stirred at room temperature (22°C) for 14 hours. After completion of the reaction, the solvent was removed by rotary evaporation. The residue was dissolved in ethyl acetate (250 mL) and extracted with 0.25N aqueous hydrochloric acid (100 mL). The organic phase was separated and washed sequentially with saturated aqueous ammonium chloride solution (3 x 50 mL) and dried over anhydrous sodium sulfate. Finally, the solvent was removed by rotary evaporation to give the white solid product oxocarbonyl-4-hydroxyaniline (20.91 g, 100% yield, ESI-MS (m/z) 208.1 [M-H]-).

References

[1] Patent: EP1609789, 2005, A1. Location in patent: Page/Page column 12
[2] Tetrahedron Letters, 2011, vol. 52, # 12, p. 1260 - 1264
[3] Chemical Communications, 2013, vol. 49, # 51, p. 5757 - 5759
[4] Organic Letters, 2016, vol. 18, # 21, p. 5728 - 5731
[5] Comptes Rendus Chimie, 2013, vol. 16, # 11, p. 962 - 966

4-N-BOC-AMINOPHENOL Preparation Products And Raw materials

Raw materials

Preparation Products

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4-N-BOC-AMINOPHENOL Suppliers

China 98 Europe 1 France 1 Germany 1 India 3 Japan 1 Switzerland 1 United Kingdom 5 United States 13 Global 124

Zhengzhou kangnuochenrui Chemical Technology Co.,Ltd

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View Lastest Price from 4-N-BOC-AMINOPHENOL manufacturers

Qingdao RENAS Polymer Material Co., Ltd.

Product: tert-butyl (4-hydroxyphenyl)carbamate 54840-15-2
Price: US $0.00/kg
Min. Order: 20kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2025-05-06

Career Henan Chemical Co

Product: tert-Butyl (4-hydroxyphenyl)carbamate 54840-15-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200kg
Release date: 2018-12-25

54840-15-2, 4-N-BOC-AMINOPHENOLRelated Search:

tert-butyl 4-ethoxyphenylcarbamate ANTHRANILIC ACID, N-BOC-5-HYDROXY TERT-BUTYL 6-HYDROXY-3,4-DIHYDROQUINOLINE-1(2H)-CARBOXYLATE ANTHRANILIC ACID, N-BOC-N-METHYL-5-METHOXY BOC-5-AMINO-2-METHOXYBENZOIC ACID (4-HYDROXY-NAPHTHALEN-1-YL)-CARBAMIC ACID TERT-BUTYL ESTER 6-METHOXY-3,4-DIHYDRO-2H-QUINOXALINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 2-TERT-BUTOXYCARBONYLAMINO-4,5-DIMETHOXY-BENZOIC ACID 4-N-BOC-AMINOPHENOL tert-Butyl 2-iodo-4-methoxyphenylcarbamate Benzoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-5-methoxy- (9CI) 5-(N-TERT-BUTOXYCARBONYLAMINO)SALICYLIC ACID TERT-BUTYL-4-METHOXYCARBANILATE 2-TERT-BUTOXYCARBONYLAMINO-5-TRIFLUOROMETHOXY-BENZOIC ACID TERT-BUTYL 6-METHOXY-3,4-DIHYDROQUINOLINE-1(2H)-CARBOXYLATE BOC-2-AMINO-3,4,5-TRIMETHOXYBENZOIC ACID N-BOC-4-ETHOXY-2-IODOPHENYLAMINE TERT-BUTYL N-(4-METHOXYPHENYL)-N-(METHYLSULFONYL)CARBAMATE

N-BOC-4-HYDROXY ANILINE

4-(BOC-AMINO)PHENOL

4-N-BOC-AMINOPHENOL

(4-HYDROXY-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER

Carbamic acid, (4-hydroxyphenyl)-, 1,1-dimethylethyl ester (9CI)

tert-butyl 4-hydroxyphenylcarbamate

1,1-DiMethylethyl (4-hydroxyphenyl)carbaMate

tert-Butyl N-(4-hydroxyphenyl)carbamate

tert-Butyl p-hydroxycarbanilate

N-Boc-4-hydroxyaniline 97%

Carbamic acid, N-(4-hydroxyphenyl)-, 1,1-dimethylethyl ester

N-Boc-4-hydroxyaniline,95%

<i>N</i>-Boc-4-hydroxyaniline

54840-15-2

C11H15NO3

Oxygen Compounds

Organic Building Blocks

Building Blocks

Amino Alcohols

N-BOC