3-(difluoromethoxy)pyridin-2-amine

Product Name: 3-(difluoromethoxy)pyridin-2-amine
CAS No.: 947249-14-1
Chemical Name: 3-(difluoromethoxy)pyridin-2-amine
Synonyms: 3-(difluoromethoxy)pyridin-2-amine;3-(Difluoromethoxy)-2-pyridinamine;2-Amino-3-(difluoromethoxy)pyridine;2-Pyridinamine, 3-(difluoromethoxy)-
CBNumber: CB91704564
Molecular Formula: C6H6F2N2O
Formula Weight: 160.12
MOL File: 947249-14-1.mol

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3-(difluoromethoxy)pyridin-2-amine Property

Boiling point:: 228.6±35.0 °C(Predicted)
Density: 1.331±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 7.36±0.10(Predicted)
Appearance: Off-white to brown Solid

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D456355
Product name: 3-(Difluoromethoxy)pyridin-2-amine
Packaging: 50mg
Price: $65
Updated: 2021/12/16

Apolloscientific

Product number: PC448010
Product name: 3-(Difluoromethoxy)pyridin-2-amine
Purity: 95%
Packaging: 1g
Price: $110
Updated: 2021/12/16

AK Scientific

Product number: 8671BB
Product name: 3-(Difluoromethoxy)pyridin-2-amine
Packaging: 250mg
Price: $120
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-3-D8
Product name: 3-(Difluoromethoxy)pyridin-2-amine
Packaging: 1g
Price: $176
Updated: 2021/12/16

Apolloscientific

Product number: PC448010
Product name: 3-(Difluoromethoxy)pyridin-2-amine
Purity: 95%
Packaging: 250mg
Price: $37
Updated: 2021/12/16

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3-(difluoromethoxy)pyridin-2-amine Chemical Properties,Usage,Production

Synthesis

1111637-77-4

947249-14-1

General procedure for the synthesis of 3-(difluoromethoxy)pyridin-2-amine from 3-(difluoromethoxy)-2-nitropyridine: 3-(difluoromethoxy)-2-nitropyridine (450 mg, 2.37 mmol) was dissolved in a mixed solvent of ethanol (2 mL) and acetic acid (2 mL) and reduced iron powder (397 mg, 7.10 mmol) was added. The reaction mixture was stirred at 100 °C overnight. Since the ingredients were not fully reacted, reduced iron powder (397 mg, 7.10 mmol) was added again and stirring was continued at 100 °C overnight. After completion of the reaction, the mixture was filtered through diatomaceous earth and the filtrate was concentrated under reduced pressure. To the concentrated residue was added saturated aqueous sodium bicarbonate and extracted three times with ethyl acetate. The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and purified by silica gel column chromatography (eluent: chloroform/methanol=9/1, v/v) to afford the target product 3-(difluoromethoxy)pyridin-2-amine (250 mg, 66% yield). The product was detected by electrospray ionization mass spectrometry (ESIMS), m/z: 161 (M + H)+; 1H NMR (270 MHz, CDCl3, δ): 4.79 (broad single peak, 2H), 6.14-6.80 (multiple peaks, 2H), 7.19-7.35 (multiple peaks, 1H), 7.85-7.98 (multiple peaks, 1H).

References

[1] Patent: WO2010/100127, 2010, A1. Location in patent: Page/Page column 73
[2] Patent: WO2009/16460, 2009, A2. Location in patent: Page/Page column 55-56
[3] Patent: EP2740730, 2014, A1. Location in patent: Paragraph 0346
[4] Patent: WO2014/111496, 2014, A1. Location in patent: Page/Page column 108
[5] Patent: WO2015/91889, 2015, A1. Location in patent: Page/Page column 73; 74

3-(difluoromethoxy)pyridin-2-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(difluoromethoxy)pyridin-2-amine Suppliers

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947249-14-1, 3-(difluoromethoxy)pyridin-2-amineRelated Search:

3-(difluoromethoxy)pyridin-2-amine

2-Amino-3-(difluoromethoxy)pyridine

3-(Difluoromethoxy)-2-pyridinamine

2-Pyridinamine, 3-(difluoromethoxy)-

947249-14-1