3-CHLORO-5-FLUOROPHENYLACETONITRILE
- Product Name
- 3-CHLORO-5-FLUOROPHENYLACETONITRILE
- CAS No.
- 493038-93-0
- Chemical Name
- 3-CHLORO-5-FLUOROPHENYLACETONITRILE
- Synonyms
- SALOR-INT L301035-1EA;3-Chloro-5-fluorophenylacetoni;3-CHLORO-5-FLUOROBENZYL CYANIDE;3-CHLORO-5-FLUOROPHENYLACETONITRILE;3-Chloro-5-fluorobenzeneacetonitrile;3-Chloro-5-fluorophenylacetonitrile,97%;Benzeneacetonitrile, 3-chloro-5-fluoro-;2-(3-Chloro-5-fluorophenyl)acetonitrile;3-Chloro-5-fluorophenyl acetonitrile,98%
- CBNumber
- CB9170634
- Molecular Formula
- C8H5ClFN
- Formula Weight
- 169.58
- MOL File
- 493038-93-0.mol
3-CHLORO-5-FLUOROPHENYLACETONITRILE Property
- Boiling point:
- 244.7±25.0 °C(Predicted)
- Density
- 1.286±0.06 g/cm3(Predicted)
- refractive index
- 1.523-1.525
- storage temp.
- Sealed in dry,Room Temperature
- form
- clear liquid
- color
- Colorless to Light yellow to Light orange
- Water Solubility
- Not miscible or difficult to mix with water.
Safety
- Hazard Codes
- Xn,T
- Risk Statements
- 36/37/38-20/21/22-36/37/39
- Safety Statements
- 36/37/39-26
- RIDADR
- UN 3276 6.1/PG III
- Hazard Note
- Toxic
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H300Fatal if swallowed
H311Toxic in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P309IF exposed or if you feel unwell:
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- C3330
- Product name
- 3-Chloro-5-fluorobenzyl Cyanide
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $53
- Updated
- 2025/07/31
- Product number
- C3330
- Product name
- 3-Chloro-5-fluorobenzyl Cyanide
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $206
- Updated
- 2025/07/31
- Product number
- C989188
- Product name
- 3-Chloro-5-fluorophenylacetonitrile
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 3737-7-X1
- Product name
- 3-Chloro-5-fluorophenylacetonitrile
- Packaging
- 1g
- Price
- $63
- Updated
- 2021/12/16
- Product number
- PC0331
- Product name
- 3-Chloro-5-fluorophenylacetonitrile
- Packaging
- 5g
- Price
- $189
- Updated
- 2021/12/16
3-CHLORO-5-FLUOROPHENYLACETONITRILE Chemical Properties,Usage,Production
Chemical Properties
clear yellow liquid
Uses
It is employed as a intermediates for pharmaceutical.
Synthesis
773837-37-9
493024-39-8
493038-93-0
3-Chloro-5-fluorobenzyl bromide (58.23 g, 260 mmol) and acetic acid (5.35 mL, 93.6 mmol) were dissolved in toluene (260 mL). Aqueous sodium cyanide (195 mL, 48.57 g, 990 mmol) and tributylbenzyl ammonium chloride (5.68 g, 18.2 mmol) were added slowly and dropwise with stirring. The reaction mixture was stirred continuously at room temperature for 4 hours. After completion of the reaction, the organic layer was separated and washed sequentially with deionized water (200 mL) and saturated sodium chloride solution (200 mL). The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent. The crude product obtained was purified by basic silica gel column chromatography using hexane-ethyl acetate (4:1, v/v) as eluent to give 3-chloro-5-fluorophenylacetonitrile (44.89 g, 100% yield) as a brown oil. The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3): δ 3.74 (2H, s), 6.99 (1H, d, J = 8.7 Hz), 7.05-7.13 (1H, m), 7.15 (1H, s).
References
[1] Patent: EP2530078, 2012, A1. Location in patent: Page/Page column 118
3-CHLORO-5-FLUOROPHENYLACETONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
3-CHLORO-5-FLUOROPHENYLACETONITRILE Suppliers
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