ChemicalBook > CAS DataBase List > 3-CHLORO-5-FLUOROPHENYLACETONITRILE

3-CHLORO-5-FLUOROPHENYLACETONITRILE

Product Name: 3-CHLORO-5-FLUOROPHENYLACETONITRILE
CAS No.: 493038-93-0
Chemical Name: 3-CHLORO-5-FLUOROPHENYLACETONITRILE
Synonyms: SALOR-INT L301035-1EA;3-Chloro-5-fluorophenylacetoni;3-CHLORO-5-FLUOROBENZYL CYANIDE;3-CHLORO-5-FLUOROPHENYLACETONITRILE;3-Chloro-5-fluorobenzeneacetonitrile;3-Chloro-5-fluorophenylacetonitrile,97%;Benzeneacetonitrile, 3-chloro-5-fluoro-;2-(3-Chloro-5-fluorophenyl)acetonitrile;3-Chloro-5-fluorophenyl acetonitrile,98%
CBNumber: CB9170634
Molecular Formula: C8H5ClFN
Formula Weight: 169.58
MOL File: 493038-93-0.mol

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3-CHLORO-5-FLUOROPHENYLACETONITRILE Property

Boiling point:: 244.7±25.0 °C(Predicted)
Density: 1.286±0.06 g/cm3(Predicted)
refractive index: 1.523-1.525
storage temp.: Sealed in dry,Room Temperature
form: clear liquid
color: Colorless to Light yellow to Light orange
Water Solubility: Not miscible or difficult to mix with water.

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Safety

Hazard Codes: Xn,T
Risk Statements: 36/37/38-20/21/22-36/37/39
Safety Statements: 36/37/39-26
RIDADR: UN 3276 6.1/PG III
Hazard Note: Toxic
HazardClass: 6.1
PackingGroup: III
HS Code: 2926907090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

H311Toxic in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P309IF exposed or if you feel unwell:

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C3330
Product name: 3-Chloro-5-fluorobenzyl Cyanide
Purity: >98.0%(GC)
Packaging: 1g
Price: $53
Updated: 2025/07/31

TCI Chemical

Product number: C3330
Product name: 3-Chloro-5-fluorobenzyl Cyanide
Purity: >98.0%(GC)
Packaging: 5g
Price: $206
Updated: 2025/07/31

TRC

Product number: C989188
Product name: 3-Chloro-5-fluorophenylacetonitrile
Packaging: 50mg
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: PC0331
Product name: 3-Chloro-5-fluorophenylacetonitrile
Packaging: 1g
Price: $57
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3737-7-X1
Product name: 3-Chloro-5-fluorophenylacetonitrile
Packaging: 1g
Price: $63
Updated: 2021/12/16

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3-CHLORO-5-FLUOROPHENYLACETONITRILE Chemical Properties,Usage,Production

Chemical Properties

clear yellow liquid

Uses

It is employed as a intermediates for pharmaceutical.

Synthesis

773837-37-9

493024-39-8

493038-93-0

3-Chloro-5-fluorobenzyl bromide (58.23 g, 260 mmol) and acetic acid (5.35 mL, 93.6 mmol) were dissolved in toluene (260 mL). Aqueous sodium cyanide (195 mL, 48.57 g, 990 mmol) and tributylbenzyl ammonium chloride (5.68 g, 18.2 mmol) were added slowly and dropwise with stirring. The reaction mixture was stirred continuously at room temperature for 4 hours. After completion of the reaction, the organic layer was separated and washed sequentially with deionized water (200 mL) and saturated sodium chloride solution (200 mL). The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent. The crude product obtained was purified by basic silica gel column chromatography using hexane-ethyl acetate (4:1, v/v) as eluent to give 3-chloro-5-fluorophenylacetonitrile (44.89 g, 100% yield) as a brown oil. The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3): δ 3.74 (2H, s), 6.99 (1H, d, J = 8.7 Hz), 7.05-7.13 (1H, m), 7.15 (1H, s).

References

[1] Patent: EP2530078, 2012, A1. Location in patent: Page/Page column 118

3-CHLORO-5-FLUOROPHENYLACETONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-CHLORO-5-FLUOROPHENYLACETONITRILE Suppliers

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493038-93-0, 3-CHLORO-5-FLUOROPHENYLACETONITRILERelated Search:

3-CHLORO-5-FLUOROPHENYLACETONITRILE

3-CHLORO-5-FLUOROBENZYL CYANIDE

SALOR-INT L301035-1EA

3-Chloro-5-fluorophenyl acetonitrile,98%

3-Chloro-5-fluorophenylacetoni

2-(3-Chloro-5-fluorophenyl)acetonitrile

Benzeneacetonitrile, 3-chloro-5-fluoro-

3-Chloro-5-fluorophenylacetonitrile,97%

3-Chloro-5-fluorobenzeneacetonitrile

493038-93-0

Fluorine series

Nitrile