ChemicalBook > CAS DataBase List > 8-CHLORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE

8-CHLORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE

Product Name
8-CHLORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE
CAS No.
61563-33-5
Chemical Name
8-CHLORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE
Synonyms
8-CHLORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HCL;8-CHLORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE
CBNumber
CB9172416
Molecular Formula
C9H11Cl2N
Formula Weight
204.1
MOL File
61563-33-5.mol
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8-CHLORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE Property

storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
C433410
Product name
8-Chloro-1,2,3,4-tetrahydroisoquinolinehydrochloride
Packaging
50mg
Price
$45
Updated
2021/12/16
TRC
Product number
C433410
Product name
8-Chloro-1,2,3,4-tetrahydroisoquinolinehydrochloride
Packaging
500mg
Price
$220
Updated
2021/12/16
Ark Pharm
Product number
P000588336
Product name
8-Chloro-1,2,3,4-tetrahydroisoquinoline hydrochloride
Purity
95%
Packaging
250mg
Price
$30
Updated
2021/12/16
Ark Pharm
Product number
P000588336
Product name
8-Chloro-1,2,3,4-tetrahydroisoquinoline hydrochloride
Purity
95%
Packaging
1g
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC143159
Product name
8-Chloro-1,2,3,4-tetrahydroisoquinoline hydrochloride
Packaging
50mg
Price
$79
Updated
2021/12/16
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8-CHLORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE Chemical Properties,Usage,Production

Synthesis

64834-58-8

61563-33-5

General procedure for the synthesis of 8-chloro-1,2,3,4-tetrahydroisoquinoline hydrochloride from 2-(2-chloro-benzylamino)-ethanol: To a mixture of 2-(2-chloro-benzylamino)-ethanol (10.00 g, 45.05 mmol) and ammonium chloride (1.76 g, 32.9 mmol) was added, at 185°C, aluminum chloride (11.60 g, 87.02 mmol). After 40 and 70 minutes of reaction, additional portions of aluminum chloride (5.80 g, 43.5 mmol and 11.60 g, 87.02 mmol) were added and the mixture continued to be stirred at the same temperature. The reaction mixture was poured into a slurry of ice and 3M HCl solution under strong stirring. The resulting solution was alkalized to pH 14 with 40% NaOH solution and subsequently extracted with ether (300 mL and 2 x 150 mL). The organic layers were combined, dried with anhydrous magnesium sulfate, and the solvent was evaporated to give an oily residue (7.07 g, 94%) containing both isomers (9:1 ratio, as determined by GC-MS). The oily substance was dissolved in isopropanol (50 mL) and the isopropanol solution of hydrochloric acid gas was added dropwise. The precipitate was collected by filtration and the residue was recrystallized twice with isopropanol to give 8-chloro-1,2,3,4-tetrahydroisoquinoline hydrochloride (2.32 g, 25%) as a light brown solid. Melting point 244-246 °C (isopropanol, off-white solid).IR (KBr): ν= 3423, 1587, 1468 cm-1.1H NMR (400 MHz, CD3OD): δ= 7.37 (br d, J = 7.7Hz, 1H), 7.31 (t, J = 7.7Hz, 1H), 7.24 (br d, J = 7.7Hz. 1H), 4.37 (s, 2H), 3.49 (t, J = 6.3 Hz, 2H), 3.14 (br t, J = 6.3 Hz, 2H).13C NMR (100 MHz, CD3OD): δ= 135.6, 133.3, 130.2, 129.0, 128.8, 127.3, 43.9, 42.2, 26.2. HRMS calculated value C9H11ClN + ([M + H] +): 168.0575, measured value: 168.0580.

References

[1] Tetrahedron, 2018, vol. 74, # 49, p. 7009 - 7017

8-CHLORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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8-CHLORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE Suppliers

China 39 Germany 1 India 2 Ukraine 1 United Kingdom 4 United States 10 Global 57
Alchem Pharmtech,Inc.
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View Lastest Price from 8-CHLORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE manufacturers

Career Henan Chemical Co
Product
8-CHLORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE 61563-33-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2019-12-20

61563-33-5, 8-CHLORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDERelated Search:

1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE 7,8-dichloro-1,2,3,4-tetrahydroisoquinolinium chloride 8-CHLORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE 8-CHLORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE

  • 8-CHLORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE
  • 8-CHLORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HCL
  • 61563-33-5