5-Hydroxyisoquinoline

Product Name: 5-Hydroxyisoquinoline
CAS No.: 2439-04-5
Chemical Name: 5-Hydroxyisoquinoline
Synonyms: NSC 51787;5-ISOQUINOLINOL;ISOQUINOLIN-5-OL;Isoquinoline-5-ol;5-Hydroxyisoquinolne;5-Hydroxyisoquin din;5-HYDROXYISOQUINOLINE;5-Hydroxyisoquin dine;5-Hydroxyisoquinoline90%;5-Hydroxyisoquinoline>
CBNumber: CB9174379
Molecular Formula: C9H7NO
Formula Weight: 145.16
MOL File: 2439-04-5.mol

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5-Hydroxyisoquinoline Property

Melting point:: 213-215
Boiling point:: 264.27°C (rough estimate)
Density: 1.1555 (rough estimate)
refractive index: 1.4500 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 8.53±0.40(Predicted)
form: Granular Powder
color: Beige
InChI: InChI=1S/C9H7NO/c11-9-3-1-2-7-6-10-5-4-8(7)9/h1-6,11H
InChIKey: CSNXUYRHPXGSJD-UHFFFAOYSA-N
SMILES: C1C2=C(C(O)=CC=C2)C=CN=1
CAS DataBase Reference: 2439-04-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-21/22
Safety Statements: 26-37/39-36/37/39-36
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29334900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H33207
Product name: 5-Hydroxyisoquinoline
Purity: technical grade, 90%
Packaging: 5g
Price: $85
Updated: 2025/07/31

Sigma-Aldrich

Product number: H33207
Product name: 5-Hydroxyisoquinoline
Purity: technical grade, 90%
Packaging: 25g
Price: $436
Updated: 2023/06/20

TCI Chemical

Product number: H1259
Product name: 5-Hydroxyisoquinoline
Purity: >96.0%(GC)(T)
Packaging: 5g
Price: $198
Updated: 2025/07/31

TCI Chemical

Product number: H1259
Product name: 5-Hydroxyisoquinoline
Purity: >96.0%(GC)(T)
Packaging: 25g
Price: $698
Updated: 2025/07/31

TRC

Product number: H953260
Product name: 5-Hydroxyisoquinoline
Packaging: 100mg
Price: $50
Updated: 2021/12/16

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5-Hydroxyisoquinoline Chemical Properties,Usage,Production

Chemical Properties

beige granular powder

Uses

5-Hydroxyisoquinoline is a reagent used in the preparation of PARP inhibitor.

Synthesis

27655-40-9

2439-04-5

The general procedure for the synthesis of 5-hydroxyisoquinoline from 5-isoquinolinesulfonic acid is as follows: 23 g of 5-isoquinolinesulfonic acid is added to 400 ml of water, followed by 60 g of sodium hydroxide. The reaction mixture was heated to reflux and stirred continuously under this condition for 24 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted with dilute hydrochloric acid to 5. Then, ethyl acetate was added for extraction and the organic phase was separated and collected. The organic phase was concentrated and the resulting residue was purified by silica gel column chromatography to yield 16 g of 5-hydroxyisoquinoline.

References

[1] Acta Poloniae Pharmaceutica, 1994, vol. 51, # 6, p. 479 - 482
[2] Patent: CN107778231, 2018, A. Location in patent: Paragraph 0023; 0024

5-Hydroxyisoquinoline Preparation Products And Raw materials

Raw materials

FUMING SULFURIC ACID Isoquinoline Potassium hydroxide Sodium hydroxide Sulfuric acid

Preparation Products

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5-Hydroxyisoquinoline Suppliers

Americas 1 Belgium 1 Canada 1 China 127 Europe 1 Germany 3 India 3 Japan 2 Slovakia 1 Switzerland 1 United Kingdom 6 United States 25 Global 172

MDP ChemControl Ltd.

Tel: --
Fax: --
Email: chemcontrol@nextra.sk
Country: Slovakia
ProdList: 6700
Advantage: 60

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View Lastest Price from 5-Hydroxyisoquinoline manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 5-Hydroxyisoquinoline 2439-04-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-04-07

Shaanxi Dideu Medichem Co. Ltd

Product: 5-Hydroxyisoquinoline 2439-04-5
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2020-04-29

Honest Joy Holdings Limited

Product: 5-Hydroxyisoquinoline
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.7%
Supply Ability: 100 tons
Release date: 2022-02-18

2439-04-5, 5-HydroxyisoquinolineRelated Search:

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