Iodoacetonitrile
- Product Name
- Iodoacetonitrile
- CAS No.
- 624-75-9
- Chemical Name
- Iodoacetonitrile
- Synonyms
- 2-Iodoacetonitrile;AKOS 91685;IODOACETONITRILE;10doacetonitrile;Cyanoiodomethane;Cyanomethyl iodide;iodomethyl cyanide;Acetonitrile, iodo-;Iodoacetonitrile>Iodoacetonitrile 98%
- CBNumber
- CB9179657
- Molecular Formula
- C2H2IN
- Formula Weight
- 166.95
- MOL File
- 624-75-9.mol
Iodoacetonitrile Property
- Boiling point:
- 182-184 °C/720 mmHg (lit.)
- Density
- 2.307 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.574(lit.)
- RTECS
- AM0740000
- Flash point:
- 187 °F
- storage temp.
- 2-8°C
- solubility
- Chloroform, Methanol (Slightly)
- form
- Liquid
- Specific Gravity
- 2.307
- color
- Clear red to brown
- Water Solubility
- Soluble in benzene, alcohol, acetone, ether. Slightly soluble in water. Insoluble in hexane.
- Sensitive
- Light Sensitive
- BRN
- 1734628
- Exposure limits
- NIOSH: IDLH 25 mg/m3
- Stability:
- Light Sensitive
- CAS DataBase Reference
- 624-75-9(CAS DataBase Reference)
- NIST Chemistry Reference
- Iodoacetonitrile(624-75-9)
- EPA Substance Registry System
- Acetonitrile, iodo- (624-75-9)
Safety
- Hazard Codes
- C,T
- Risk Statements
- 22-34-36/37/38-23/24/25
- Safety Statements
- 26-36/37/39-45-24/25
- RIDADR
- UN 3265 8/PG 2
- WGK Germany
- 3
- F
- 8-10-19-21
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29269090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- I6903
- Product name
- Iodoacetonitrile
- Purity
- 98%
- Packaging
- 10g
- Price
- $115
- Updated
- 2025/07/31
- Product number
- I6903
- Product name
- Iodoacetonitrile
- Purity
- 98%
- Packaging
- 50g
- Price
- $342
- Updated
- 2025/07/31
- Product number
- I0419
- Product name
- Iodoacetonitrile
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $150
- Updated
- 2025/07/31
- Product number
- I0419
- Product name
- Iodoacetonitrile
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $685
- Updated
- 2025/07/31
- Product number
- I686760
- Product name
- Iodoacetonitrile
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
Iodoacetonitrile Chemical Properties,Usage,Production
Chemical Properties
clear red to brown liquid
Uses
Iodoacetonitrile is used for alkylation of nucleophiles. It undergoes Reformatsky and Wittig-type reactions with aldehydes.
Synthesis
590-17-0
624-75-9
Step 2. The method followed the synthesis of literature S5: 2,6-piperidinedimethanol (3.80 g, 26.21 mmol), iodoacetonitrile (5.24 g, 31.45 mmol), triethylamine (Et3N, 4.38 mL, 31.45 mmol) and anhydrous N,N-dimethylformamide (DMF, 20 mL) were added to the reaction system. Upon completion of the reaction, the product was purified by fast column chromatography using a solvent mixture of dichloromethane (CH2Cl2) and methanol (CH3OH) (9:1, v/v) as eluent to afford iodoacetonitrile as a straw-colored oily substance (2.5 g, 53% yield). the molecular ion peak m/z (M + H)+ was determined by FAB MS to be 185. iodoacetonitrile was prepared using the Finkelstein reaction: Bromoacetonitrile (BrCH2CN, 3.77 g, 0.0314 mmol) was added dropwise to an acetone solution of sodium iodide (NaI, 4.71 g, 0.031 mmol) under stirring. A precipitate of sodium bromide (NaBr) was produced within a few minutes of the reaction, indicating that a halogen exchange reaction had occurred. The sodium bromide was removed by filtration and the acetone was subsequently evaporated under vacuum to give the crude product iodoacetonitrile (5.24 g, 100% yield).
References
[1] Patent: WO2005/61453, 2005, A1. Location in patent: Page/Page column 15
[2] Journal of the American Chemical Society, 1980, vol. 102, # 4, p. 1367 - 1371
Iodoacetonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
Iodoacetonitrile Suppliers
- Tel
- --
- Fax
- --
- info@pschemicals.com
- Country
- The Netherlands
- ProdList
- 2724
- Advantage
- 58
View Lastest Price from Iodoacetonitrile manufacturers
- Product
- Iodoacetonitrile 624-75-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Iodoacetonitrile 624-75-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08
- Product
- Iodoacetonitrile 624-75-9
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2020-01-09