BOC-LEU-OME
- Product Name
- BOC-LEU-OME
- CAS No.
- 63096-02-6
- Chemical Name
- BOC-LEU-OME
- Synonyms
- BOC-LEU-OME;Boc-L-Leu-OMe;Boc-Leu-OMe-OH;Boc-Leu-OMe,97%;Boc-L-Leucine methyl;BOC-LEU-OME USP/EP/BP;BOC-L-LEUCYL METHYL ESTER;BOC-L-LEUCINE METHYL ESTER;(Tert-Butoxy)Carbonyl Leu-OMe;N-(tert-Butoxycarbonyl)-
L< - CBNumber
- CB9180192
- Molecular Formula
- C12H23NO4
- Formula Weight
- 245.32
- MOL File
- 63096-02-6.mol
BOC-LEU-OME Property
- Melting point:
- 147-149℃
- Boiling point:
- 205 °C(lit.)
- Density
- 0.991 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.44(lit.)
- Flash point:
- 113 °C
- storage temp.
- Sealed in dry,2-8°C
- form
- Liquid
- color
- Colorless to light yellow
- optical activity
- [α]22/D 18°, neat
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 265218
- Product name
- Boc-L-leucine methyl ester
- Packaging
- 1g
- Price
- $353
- Updated
- 2021/12/16
- Product number
- FB49245
- Product name
- Boc-L-leucine methyl ester
- Packaging
- 10g
- Price
- $475.8
- Updated
- 2021/12/16
- Product number
- J52073
- Product name
- Boc-Leu-OMe
- Packaging
- 100g
- Price
- $495
- Updated
- 2021/12/16
- Product number
- 07855
- Product name
- Boc-L-leucinemethylester,98%(HPLC)
- Purity
- 98%(HPLC)
- Packaging
- 25G
- Price
- $741.44
- Updated
- 2021/12/16
- Product number
- FB49245
- Product name
- Boc-L-leucine methyl ester
- Packaging
- 25g
- Price
- $761.5
- Updated
- 2021/12/16
BOC-LEU-OME Chemical Properties,Usage,Production
Chemical Properties
Light yellowish liquid
Uses
Boc-L-leucine Methyl Ester is used in preparation of heterocyclic compound as hematopoietic prostaglandin D synthase (H-PGDS) inhibitor.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
24424-99-5
7517-19-3
63096-02-6
General procedure for the synthesis of (tert-butoxycarbonyl)-L-leucine methyl ester from di-tert-butyl dicarbonate and L-leucine methyl ester hydrochloride: firstly, L-leucine methyl ester hydrochloride and K2CO3 were suspended in water and stirred for 1 hour to release the free amino acid ester. Subsequently, the free amino acid ester was extracted with CH2Cl2 and the organic phase was dried with MgSO4. Evaporation of CH2Cl2 under reduced pressure gave the free amino acid ester, which should be used immediately in the next step of the N-Boc protection reaction. Next, the free amino acid ester (1 mmol) was dissolved in 1 mL of ethanol and added to a solution of di-tert-butyl dicarbonate (1.2 mmol) and guanidine hydrochloride (15 mol%) in ethanol (1 mL) that had been preheated to 35-40 °C and the reaction was stirred at the appropriate temperature. After completion of the reaction, the post-treatment procedure was the same as that for conventional amines.
References
[1] Tetrahedron Letters, 2011, vol. 52, # 12, p. 1260 - 1264
[2] Chemistry - A European Journal, 2013, vol. 19, # 12, p. 3817 - 3821
[3] Journal of Organic Chemistry, 1995, vol. 60, # 24, p. 8074 - 8080
[4] Chemical Biology and Drug Design, 2012, vol. 79, # 2, p. 216 - 222
[5] European Journal of Medicinal Chemistry, 2017, vol. 135, p. 142 - 158
BOC-LEU-OME Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from BOC-LEU-OME manufacturers
- Product
- BOC-LEU-OME 63096-02-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-08