ChemicalBook > CAS DataBase List > BOC-LEU-OME

BOC-LEU-OME

Product Name
BOC-LEU-OME
CAS No.
63096-02-6
Chemical Name
BOC-LEU-OME
Synonyms
BOC-LEU-OME;Boc-L-Leu-OMe;Boc-Leu-OMe-OH;Boc-Leu-OMe,97%;Boc-L-Leucine methyl;BOC-LEU-OME USP/EP/BP;BOC-L-LEUCYL METHYL ESTER;BOC-L-LEUCINE METHYL ESTER;(Tert-Butoxy)Carbonyl Leu-OMe;N-(tert-Butoxycarbonyl)-L<
CBNumber
CB9180192
Molecular Formula
C12H23NO4
Formula Weight
245.32
MOL File
63096-02-6.mol
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BOC-LEU-OME Property

Melting point:
147-149℃
Boiling point:
205 °C(lit.)
Density 
0.991 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.44(lit.)
Flash point:
113 °C
storage temp. 
Sealed in dry,2-8°C
form 
Liquid
color 
Colorless to light yellow
optical activity
[α]22/D 18°, neat
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Usbiological
Product number
265218
Product name
Boc-L-leucine methyl ester
Packaging
1g
Price
$353
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB49245
Product name
Boc-L-leucine methyl ester
Packaging
10g
Price
$475.8
Updated
2021/12/16
AK Scientific
Product number
J52073
Product name
Boc-Leu-OMe
Packaging
100g
Price
$495
Updated
2021/12/16
Chem-Impex
Product number
07855
Product name
Boc-L-leucinemethylester,98%(HPLC)
Purity
98%(HPLC)
Packaging
25G
Price
$741.44
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB49245
Product name
Boc-L-leucine methyl ester
Packaging
25g
Price
$761.5
Updated
2021/12/16
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BOC-LEU-OME Chemical Properties,Usage,Production

Chemical Properties

Light yellowish liquid

Uses

Boc-L-leucine Methyl Ester is used in preparation of heterocyclic compound as hematopoietic prostaglandin D synthase (H-PGDS) inhibitor.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

24424-99-5

7517-19-3

63096-02-6

General procedure for the synthesis of (tert-butoxycarbonyl)-L-leucine methyl ester from di-tert-butyl dicarbonate and L-leucine methyl ester hydrochloride: firstly, L-leucine methyl ester hydrochloride and K2CO3 were suspended in water and stirred for 1 hour to release the free amino acid ester. Subsequently, the free amino acid ester was extracted with CH2Cl2 and the organic phase was dried with MgSO4. Evaporation of CH2Cl2 under reduced pressure gave the free amino acid ester, which should be used immediately in the next step of the N-Boc protection reaction. Next, the free amino acid ester (1 mmol) was dissolved in 1 mL of ethanol and added to a solution of di-tert-butyl dicarbonate (1.2 mmol) and guanidine hydrochloride (15 mol%) in ethanol (1 mL) that had been preheated to 35-40 °C and the reaction was stirred at the appropriate temperature. After completion of the reaction, the post-treatment procedure was the same as that for conventional amines.

References

[1] Tetrahedron Letters, 2011, vol. 52, # 12, p. 1260 - 1264
[2] Chemistry - A European Journal, 2013, vol. 19, # 12, p. 3817 - 3821
[3] Journal of Organic Chemistry, 1995, vol. 60, # 24, p. 8074 - 8080
[4] Chemical Biology and Drug Design, 2012, vol. 79, # 2, p. 216 - 222
[5] European Journal of Medicinal Chemistry, 2017, vol. 135, p. 142 - 158

BOC-LEU-OME Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-LEU-OME Suppliers

China 75 Germany 2 India 2 Japan 2 Switzerland 2 United Kingdom 3 United States 8 Global 94
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View Lastest Price from BOC-LEU-OME manufacturers

Career Henan Chemical Co
Product
BOC-LEU-OME 63096-02-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-01-08

63096-02-6, BOC-LEU-OMERelated Search:

BOC-LEU-OME BOC-L-Leucine N-tert-Butoxycarbonyl-L-leucine N-carboxylic anhydride BOC-3-CYCLOHEXYL-L-ALANINE METHYL ESTER BOC-L-TRANSPRO(4-CN)-OBN BOC-LEU-ONP N-BOC-TRANS-4-CYANO-L-PROLINE METHYL ESTER BENZYL (+/-)-TRANS-N-BOC-4-METHYL-PIPERIDINE-2-CARBOXYLATE 4-(T-BUTYLOXYCARBONYL-LEUCYLOXYMETHYL)-PHENYLACETIC ACID N-BOC-CIS-4-CYANO-L-PROLINE METHYL ESTER H-LYS(BOC)-LEU-OME HCL Z-LYS(BOC)-LEU-OME (S)-N-ALPHA-T-BUTYLOXYCARBONYL-TRANS-4-CYANOMETHYL-PROLINE-T-BUTYL ESTER (2S,4R)-BENZYL-BOC-GAMMA-(4-BROMOBENZYL)-PYROGLUTAMATE (2S,4R)-BENZYL-BOC-GAMMA-BENZYLPYROGLUTAMATE BOC-L-TRANSPRO(CH2CH2-NH-ALLOC)-OME (S)-N-ALPHA-T-BUTYLOXYCARBONYL-TRANS-4-[2-(9-FLUORENYLMETHYLOXYCARBONYL-AMINO)ETHYL]-PROLINE METHYL ESTER (2S, 4R)-NA-BOC-4-CARBOXYLIC ACID-PROLINE DIMETHYL ESTER

  • 3-[(2-acetamido-3-phenyl-propanoyl)amino]benzoic acid
  • Methyl N-(tert-butoxycarbonyl)-L-leucinate
  • (S)-Methyl 2-((tert-butoxycarbonyl)aMino)-4-Methylpentanoate
  • Boc-L-Leucine methyl
  • L-Leucine, N-[(1,1-diMethylethoxy)carbonyl]-, Methyl ester
  • N-Boc-L-leucine Methyl ester, 97%
  • N-(tert-Butoxycarbonyl)-L-leucine methyl ester 97%
  • Boc-L-Leu-OMe
  • Boc-L-leucine methyl ester≥ 98% (HPLC)
  • N-(TERT-BUTOXYCARBONYL)-L-LEUCINE METHYL ESTER
  • N-ALPHA-T-BUTOXYCARBONYL-L-LEUCINE-METHYL ESTER
  • BOC-L-LEUCINE METHYL ESTER
  • BOC-L-LEUCYL METHYL ESTER
  • BOC-LEU-OME
  • (2S)-2-(tert-Butoxycarbonylamino)-4-methylpentanoic acid methyl ester
  • N-(tert-Butyloxycarbonyl)leucine methyl ester
  • (2S)-2-(tert-Butyloxycarbonylamino)-4-methylpentanoic acid methyl ester
  • N-(tert-Butoxycarbonyl)leucine methyl ester
  • N-(tert-Butyloxycarbonyl)-L-leucine methyl ester
  • 3-[(2-acetamido-3-phenylpropanoyl)amino]benzoic acid
  • (Tert-Butoxy)Carbonyl Leu-OMe
  • methyl (2S)-2-{[(tert-butoxy)carbonyl]amino}-4-methylpentanoate
  • methyl(2S)-4-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoate
  • BOC-LEU-OME USP/EP/BP
  • Methyl (tert-butoxycarbonyl)-L-leucinate
  • Boc-Leu-OMe,97%
  • Boc-Leu-OMe-OH
  • N-(tert-Butoxycarbonyl)-<SC>L<
  • <i>N</i>-(<i>tert</i>-Butoxycarbonyl)-<sc>L</sc>-leucine methyl ester
  • 63096-02-6
  • CH32CHCH2CHNHCO2CCH33CO2CH3
  • Amino Acid Derivatives
  • Leucine
  • Specialty Synthesis
  • Peptide Synthesis
  • Amino Acid Derivatives
  • Leucine
  • Peptide Synthesis