1-Aminobenzotriazole
- Product Name
- 1-Aminobenzotriazole
- CAS No.
- 1614-12-6
- Chemical Name
- 1-Aminobenzotriazole
- Synonyms
- ABT;1H-benzo[d][1,2,3]triazol-1-aMine;SKL134;9406-00-9;RARECHEM AQ NN 0550;TIMTEC-BB SBB004208;1-BENZOTRIAZOLAMINE;1-AMINOBENZOTRIAZOLE;3-Aminobenzotriazole;benzotriazol-1-amine
- CBNumber
- CB9185384
- Molecular Formula
- C6H6N4
- Formula Weight
- 134.14
- MOL File
- 1614-12-6.mol
1-Aminobenzotriazole Property
- Melting point:
- 81-84 °C (lit.)
- Boiling point:
- 237.24°C (rough estimate)
- Density
- 1.2769 (rough estimate)
- refractive index
- 1.7000 (estimate)
- RTECS
- DM1235000
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Soluble in DMSO (up to 30mg/ml)
- form
- Crystalline Powder
- pka
- 2.09±0.30(Predicted)
- color
- Yellow to beige or light brown
- Water Solubility
- slightly soluble
- BRN
- 607843
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
- CAS DataBase Reference
- 1614-12-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A3940
- Product name
- 1-Aminobenzotriazole
- Packaging
- 50mg
- Price
- $79.5
- Updated
- 2024/03/01
- Product number
- A3940
- Product name
- 1-Aminobenzotriazole
- Packaging
- 250mg
- Price
- $276
- Updated
- 2024/03/01
- Product number
- A1464
- Product name
- 1-Aminobenzotriazole
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $250
- Updated
- 2024/03/01
- Product number
- A1464
- Product name
- 1-Aminobenzotriazole
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $855
- Updated
- 2024/03/01
- Product number
- J63610
- Product name
- 1-Aminobenzotriazole, 98%
- Packaging
- 1g
- Price
- $479
- Updated
- 2024/03/01
1-Aminobenzotriazole Chemical Properties,Usage,Production
Description
1-Aminobenztriazole (1614-12-6) is a pan-specific cytochrome P450 inhibitor acting as a suicide substrate.1,2?Blocks omega-oxidation of arachidonic acid but not its epoxidation.3
Chemical Properties
yellow to beige or light brown crystalline powder
Uses
1-Aminobenzotriazole is used as a Suicide inhibitor of cytochrome P450 and chloroperoxidase, an inhibitor of oxidative drug metabolism in biochemical pharmacology and toxicology studies.
Uses
1-Aminobenzotriazole has been used as a cytochrome P450 inhibitor to study the effects of estrogen on H2O2-induced premature senescence of vascular smooth muscle cells from old rats It has also been used to study the estrogen receptor-mediated effects of 17β-estradiol.
Biochem/physiol Actions
1-Aminobenzotriazole (1-ABT) is used as an in vitro tool in drug discovery. It can differentiate the P450 from non-P450 enzyme systems. 1-ABT exhibits inhibitory action by covalent alteration of the heme prosthetic group in the P450 enzyme.
References
1) Mugford?et al.?(1995),?1-Aminobenzotriazole-Induced Destruction of Hepatic and Renal Cytochrome P450 in Male Sprague-Dawley Rats; Fundam. Appl. Tox.,?19?43 2) Emoto?et al.?(2005),?In Vitro Inhibitory Effect of 1-Aminobenzotriazole on Drug Oxidations in Human Liver Microsomes: A Comparison With SKF-525A; Drug Metab. Pharmacokinet.,?20?351 3) Su?et al.?(1998),?Inhibition of Renal Arachidonic Acid Omega-Hydroxylase Activity With ABT Reduces Blood Pressure in the SHR; Am. J. Physiol.,?275?R426
1-Aminobenzotriazole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-Aminobenzotriazole manufacturers
- Product
- 1-Aminobenzotriazole 1614-12-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 1-Aminobenzotriazole 1614-12-6
- Price
- US $8.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10TON
- Release date
- 2018-12-18
- Product
- 1-Aminobenzotriazole 1614-12-6
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 500kg
- Release date
- 2019-04-16