ChemicalBook > CAS DataBase List > 1-Aminobenzotriazole

1-Aminobenzotriazole

Product Name
1-Aminobenzotriazole
CAS No.
1614-12-6
Chemical Name
1-Aminobenzotriazole
Synonyms
ABT;1H-benzo[d][1,2,3]triazol-1-aMine;SKL134;9406-00-9;RARECHEM AQ NN 0550;TIMTEC-BB SBB004208;1-BENZOTRIAZOLAMINE;1-AMINOBENZOTRIAZOLE;3-Aminobenzotriazole;benzotriazol-1-amine
CBNumber
CB9185384
Molecular Formula
C6H6N4
Formula Weight
134.14
MOL File
1614-12-6.mol
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1-Aminobenzotriazole Property

Melting point:
81-84 °C (lit.)
Boiling point:
237.24°C (rough estimate)
Density 
1.2769 (rough estimate)
refractive index 
1.7000 (estimate)
RTECS 
DM1235000
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Soluble in DMSO (up to 30mg/ml)
form 
Crystalline Powder
pka
2.09±0.30(Predicted)
color 
Yellow to beige or light brown
Water Solubility 
slightly soluble
BRN 
607843
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
CAS DataBase Reference
1614-12-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A3940
Product name
1-Aminobenzotriazole
Packaging
50mg
Price
$79.5
Updated
2024/03/01
Sigma-Aldrich
Product number
A3940
Product name
1-Aminobenzotriazole
Packaging
250mg
Price
$276
Updated
2024/03/01
TCI Chemical
Product number
A1464
Product name
1-Aminobenzotriazole
Purity
>98.0%(GC)
Packaging
1g
Price
$250
Updated
2024/03/01
TCI Chemical
Product number
A1464
Product name
1-Aminobenzotriazole
Purity
>98.0%(GC)
Packaging
5g
Price
$855
Updated
2024/03/01
Alfa Aesar
Product number
J63610
Product name
1-Aminobenzotriazole, 98%
Packaging
1g
Price
$479
Updated
2024/03/01
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1-Aminobenzotriazole Chemical Properties,Usage,Production

Description

1-Aminobenztriazole (1614-12-6) is a pan-specific cytochrome P450 inhibitor acting as a suicide substrate.1,2?Blocks omega-oxidation of arachidonic acid but not its epoxidation.3

Chemical Properties

yellow to beige or light brown crystalline powder

Uses

1-Aminobenzotriazole is used as a Suicide inhibitor of cytochrome P450 and chloroperoxidase, an inhibitor of oxidative drug metabolism in biochemical pharmacology and toxicology studies.

Uses

1-Aminobenzotriazole has been used as a cytochrome P450 inhibitor to study the effects of estrogen on H2O2-induced premature senescence of vascular smooth muscle cells from old rats It has also been used to study the estrogen receptor-mediated effects of 17β-estradiol.

Biochem/physiol Actions

1-Aminobenzotriazole (1-ABT) is used as an in vitro tool in drug discovery. It can differentiate the P450 from non-P450 enzyme systems. 1-ABT exhibits inhibitory action by covalent alteration of the heme prosthetic group in the P450 enzyme.

References

1) Mugford?et al.?(1995),?1-Aminobenzotriazole-Induced Destruction of Hepatic and Renal Cytochrome P450 in Male Sprague-Dawley Rats; Fundam. Appl. Tox.,?19?43 2) Emoto?et al.?(2005),?In Vitro Inhibitory Effect of 1-Aminobenzotriazole on Drug Oxidations in Human Liver Microsomes: A Comparison With SKF-525A; Drug Metab. Pharmacokinet.,?20?351 3) Su?et al.?(1998),?Inhibition of Renal Arachidonic Acid Omega-Hydroxylase Activity With ABT Reduces Blood Pressure in the SHR; Am. J. Physiol.,?275?R426

1-Aminobenzotriazole Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Aminobenzotriazole Suppliers

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View Lastest Price from 1-Aminobenzotriazole manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
1-Aminobenzotriazole 1614-12-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
1-Aminobenzotriazole 1614-12-6
Price
US $8.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10TON
Release date
2018-12-18
Hebei Jimi Trading Co., Ltd.
Product
1-Aminobenzotriazole 1614-12-6
Price
US $1.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
500kg
Release date
2019-04-16

1614-12-6, 1-AminobenzotriazoleRelated Search:

1H-Benzotriazole Sulfanilamide Phenetidine 5-Methyl-1H-benzotriazole Sulfanilic acid p-Anisidine 4,4'-Methylenedianiline 1,2,3-1H-Triazole 1-Hydroxybenzotriazole Aniline Methyl anthranilate 4-Amino-benzenesulfonic acid monosodium salt 4-Aminobenzoic acid 1-Hydroxybenzotriazole hydrate DIETHYL (BENZOTRIAZOL-1-YL)IMINOMALONATE 5-AMINOBENZOTRIAZOLE Anthranilic acid ITSA1

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  • 1614-12-6
  • A to C
  • Benzotriazoles
  • BioChemical
  • Biochemicals and Reagents
  • Building Blocks
  • Chloroperoxidase
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors
  • Enzyme Inhibitors by Enzyme
  • Heterocyclic Building Blocks
  • Fused Ring Systems
  • inhibitor
  • Miscellaneous
  • Amines
  • API intermediates