tert-butyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate

Product Name: tert-butyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate
CAS No.: 230301-73-2
Chemical Name: tert-butyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate
Synonyms: 5-Boc-4,5,6,7-tetrahydrothieno[3,2-c]pyridine;tert-Butyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H);tert-butyl 4H,5H,6H,7H-thieno[3,2-c]pyridine-5-carboxylate;tert-butyl 6,7-dihydrothieno[3,2-c]pyridin-5(4H)-carboxylate;tert-butyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate;tert-butyl 6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carboxylate;1,1-Dimethylethyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate;6,7-dihydro-4H-thieno[3,2-c]-pyridine-5-carboxylic acid tert-butyl ester;Thieno[3,2-c]pyridine-5(4H)-carboxylic acid, 6,7-dihydro-, 1,1-diMethylethyl ester
CBNumber: CB91856209
Molecular Formula: C12H17NO2S
Formula Weight: 239.33
MOL File: 230301-73-2.mol

More

Less

tert-butyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate Property

Boiling point:: 339.1±42.0 °C(Predicted)
Density: 1.173
storage temp.: 2-8°C(protect from light)
pka: -1.51±0.20(Predicted)
Appearance: White to off-white Solid

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TRC

Product number: B699833
Product name: tert-Butyl6,7-Dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B699833
Product name: tert-Butyl6,7-Dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB144251
Product name: tert-Butyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate
Packaging: 500mg
Price: $95
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB144251
Product name: tert-Butyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate
Packaging: 1g
Price: $162
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB144251
Product name: tert-Butyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate
Packaging: 250mg
Price: $52.5
Updated: 2021/12/16

More

Less

tert-butyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate Chemical Properties,Usage,Production

Synthesis

24424-99-5

28783-41-7

230301-73-2

The general procedure for the synthesis of tert-butyl 6,7-dihydrothieno[3,2-C]pyridine-5(4H)-carboxylate from 4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride (5 g, 28.46 mmol) and di-tert-butyl dicarbonate (6.83 g, 31.30 mmol) is as follows: 4,5,6,7-tetrahydrothieno[3,2-c] pyridine hydrochloride was suspended in 150 mL of dichloromethane, triethylamine (3.17 g, 31.30 mmol) was added followed by slow addition of solid di-tert-butyl dicarbonate. The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the organic phase was washed sequentially with water (2 x 100 mL) and brine (2 x 100 mL), dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure to give a colorless oily product (6.8 g, 100% yield), which solidified to a white solid on standing.

References

[1] Patent: WO2009/49028, 2009, A1. Location in patent: Page/Page column 156
[2] Patent: CN104497008, 2016, B. Location in patent: Paragraph 0190; 0192; 0193
[3] Journal of Medicinal Chemistry, 2014, vol. 57, # 9, p. 3687 - 3706
[4] Patent: CN104341433, 2017, B. Location in patent: Paragraph 0036; 0037

tert-butyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

tert-butyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate Suppliers

China 51 China Hong Kong 1 Germany 2 India 1 United Kingdom 1 United States 11 Global 67

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Nanjing JinruiJiuAn Biotechnology Co., Ltd.

Tel: 025-58196018 800028039
Fax: 025-83453306
Email: sales@fartop.net
Country: China
ProdList: 2229
Advantage: 55

NovoChemy Ltd.

Tel: 021-31261262/ 49 (0)17662837245
Fax: (0)21-33250524
Email: sales@novochemy.com
Country: Germany
ProdList: 6328
Advantage: 58

Shanghai Topbiochem Technology Co., Ltd

Tel: +86-21-60341587
Fax: +86-21-61294319
Email: sales@topbiochem.com
Country: China
ProdList: 6175
Advantage: 58

Shanghai Keepontech Co.,Ltd

Tel: 021-54849683 13601642561
Fax: +86-21-54375689
Email: sales@keepontech.com
Country: China
ProdList: 998
Advantage: 59

Bsisun HK Imoprt And Export Company Limited

Tel: +86-18068513926
Fax: 0086-519-85153711
Country: China
ProdList: 1277
Advantage: 55

Xunteng International Trading Co.,Limited

Tel
Country: China Hong Kong
ProdList: 878
Advantage: 55

Shanghai Worldyang Chemical Co.,Ltd.

Tel: 021-021-56795766
Fax: +86-21-56795266
Email: sales@worldyachem.com
Country: China
ProdList: 9476
Advantage: 58

230301-73-2, tert-butyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylateRelated Search:

TERT-BUTYL 7-CHLORO-3,4-DIHYDRO-4-OXOQUINOLINE-1(2H)-CARBOXYLATE TERT-BUTYL 4-(4-NITROBENZOYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE tert-butyl 4-(4-bromophenyl)-5,6-dihydropyridine-1(2H)-carboxylate TERT-BUTYL 6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDINE-5(4H)-CARBOXYLATE 5H-CYCLOPENTA[B]PYRIDIN-7-AMINE, 6,7-DIHYDRO- 5H-Cyclopentapyrimidin-2-amine, 6,7-dihydro- (9CI) ethyl 6,8-difluoroH-iMidazo[1,2-a]pyridine-2-carboxylate Diethyl 6,7-dihydrothieno[3,2-c]pyridine-2,5(4H)-dicarboxylate ethyl 6,8-dichloroimidazo[1,2-a]pyridine-2-carboxylate 6,7-Dihydro-5H-cyclopenta[b]pyridine 1-oxide Carbamic acid, N-[(1R)-2,2,2-trifluoro-1-(hydroxymethyl)ethyl]-, 1,1-dimethylethyl ester TERT-BUTYL 3-(4-BROMOPHENYL)PYRROLIDINE-1-CARBOXYLATE tert-butyl 4-methoxybenzylcarbamate TERT-BUTYL 2-VINYLPIPERIDINE-1-CARBOXYLATE (S)-tert-butyl (1-hydroxypent-4-en-2-yl)carbamate 2-(Boc-amino)-2-cyclopropylethanol Carbamic acid, (1-ethyl-3-hydroxypropyl)-, 1,1-dimethylethyl ester (9CI) Carbamic acid, N-(4-cyano-2,3-dihydro-1H-inden-1-yl)-, 1,1-dimethylethyl ester

tert-butyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate

tert-butyl 4H,5H,6H,7H-thieno[3,2-c]pyridine-5-carboxylate

Thieno[3,2-c]pyridine-5(4H)-carboxylic acid, 6,7-dihydro-, 1,1-diMethylethyl ester

6,7-dihydro-4H-thieno[3,2-c]-pyridine-5-carboxylic acid tert-butyl ester

tert-butyl 6,7-dihydrothieno[3,2-c]pyridin-5(4H)-carboxylate

tert-butyl 6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carboxylate

tert-Butyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)

5-Boc-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

1,1-Dimethylethyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate

230301-73-2

Heterocycle-Pyridine series

CHIRAL CHEMICALS