8-Quinolinol, 7-fluoro-
Uses- Product Name
- 8-Quinolinol, 7-fluoro-
- CAS No.
- 35048-10-3
- Chemical Name
- 8-Quinolinol, 7-fluoro-
- Synonyms
- 7-Fluoro-8-quinolinol;8-Quinolinol, 7-fluoro-;8-Quinolinol, 7-fluoro- 7-Fluoro-8-quinolinol
- CBNumber
- CB91870177
- Molecular Formula
- C9H6FNO
- Formula Weight
- 163.15
- MOL File
- 35048-10-3.mol
8-Quinolinol, 7-fluoro- Property
- Boiling point:
- 296℃
- Density
- 1.366
- Flash point:
- 133℃
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 2.04±0.50(Predicted)
- Appearance
- Light brown to gray Solid
- InChI
- InChI=1S/C9H6FNO/c10-7-4-3-6-2-1-5-11-8(6)9(7)12/h1-5,12H
- InChIKey
- LDCRHJNNQVTBNY-UHFFFAOYSA-N
- SMILES
- N1C2C(=CC=C(F)C=2O)C=CC=1
Safety
- HS Code
- 2933491090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- F600348
- Product name
- 7-Fluoroquinolin-8-ol
- Packaging
- 50mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- PC201237
- Product name
- 7-Fluoroquinolin-8-ol
- Purity
- 98%
- Packaging
- 250mg
- Price
- $123
- Updated
- 2021/12/16
- Product number
- 4287AB
- Product name
- 7-Fluoroquinolin-8-ol
- Packaging
- 250mg
- Price
- $246
- Updated
- 2021/12/16
- Product number
- 119748
- Product name
- 7-Fluoroquinolin-8-ol
- Purity
- 95+%
- Packaging
- 1g
- Price
- $900
- Updated
- 2021/12/16
- Product number
- HCH0036973
- Product name
- 7-FLUORO-8-QUINOLINOL
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $909.56
- Updated
- 2021/12/16
8-Quinolinol, 7-fluoro- Chemical Properties,Usage,Production
Uses
7-Fluoro-8-hydroxyquinoline is a useful research chemical for organic synthesis and other chemical processes.
Synthesis
53981-25-2
56-81-5
35048-10-3
In a sealable reaction vessel, 2-amino-6-fluorophenol (4.0 g, 31.6 mmol) was dissolved in nitrobenzene (20 mL), followed by the addition of concentrated sulfuric acid (4.0 mL) in batches. Glycerol (12.0 g, 126 mmol) was added to the reaction mixture in a single addition and a change in color of the solution to dark brown was observed. After displacing the air in the reaction vessel with nitrogen, the vessel was sealed and the reaction was heated at 140 °C for 6 hours. Upon completion of the reaction, the mixture was cooled to room temperature, diluted with 30 mL of an ice-water mixture and washed three times with methyl tert-butyl ether to remove most of the nitrobenzene. Subsequently, the pH of the aqueous phase was adjusted to 6-7 by slow addition of 6 N sodium hydroxide solution. at this point, a black precipitate was generated and collected by filtration. The aqueous phase was extracted three times with ethyl acetate and the organic extract was combined with the previously collected black precipitate. The combined organic phase and precipitate were concentrated under reduced pressure and the residue was purified by silica gel column chromatography using 0-10% methanol/dichloromethane as eluent to yield 2.67 g (51.7% yield) of 7-fluoro-8-hydroxyquinoline as an off-white solid.
References
[1] Patent: WO2016/123576, 2016, A1. Location in patent: Paragraph 0276
[2] Patent: WO2012/20389, 2012, A1. Location in patent: Page/Page column 40-41
8-Quinolinol, 7-fluoro- Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 8-Quinolinol, 7-fluoro- manufacturers
- Product
- 8-Quinolinol, 7-fluoro- 35048-10-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-08-09