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PROGLUMETACIN MALEATE

Product Name
PROGLUMETACIN MALEATE
CAS No.
57132-53-3
Chemical Name
PROGLUMETACIN MALEATE
Synonyms
PROGLUMETACIN;Proglumetacine;PROGLUMETACIN MALEATE;1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid 2-[4-[3-[[4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl]oxy]propyl]-1-piperazinyl]ethyl ester;1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 2-[4-[3-[[4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl]oxy]propyl]-1-piperazinyl]ethyl ester (9CI);1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 2-[4-[3-[[4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl]oxy]propyl]-1-piperazinyl]ethyl ester, (+-)-
CBNumber
CB9188310
Molecular Formula
C46H58ClN5O8
Formula Weight
844.43
MOL File
57132-53-3.mol
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PROGLUMETACIN MALEATE Property

solubility 
DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
form 
Solid
color 
White to Pale Yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological
Product number
287563
Product name
Proglumetacin
Packaging
5mg
Price
$433
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0008070
Product name
PROGLUMETACIN
Purity
95.00%
Packaging
10MG
Price
$225.75
Updated
2021/12/16
AK Scientific
Product number
H841
Product name
Proglumetacin
Packaging
10mg
Price
$347
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0008070
Product name
PROGLUMETACIN
Purity
95.00%
Packaging
100MG
Price
$739.2
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0008070
Product name
PROGLUMETACIN
Purity
95.00%
Packaging
1G
Price
$1871.1
Updated
2021/12/16
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PROGLUMETACIN MALEATE Chemical Properties,Usage,Production

Uses

Proglumetacin Dioxalate is a new non-steroidal anti-inflammatory drug.

Definition

ChEBI: A carboxylic ester obtained by formal condensation of the carboxy group of indometacin with the hydroxy group of 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl N2-benzoyl-N,N-dipropy -alpha-glutaminate. Used (as its dimaleate salt) to control pain and inflammation associated with musculoskeletal and joint disorders. Following oral administration, it is metabolised to indometacin and proglumide, a drug with antisecretor effects that helps prevent injury to the stomach lining.

Synthesis

The reaction of N-benzoyl-N_x0002_, N_x0002_-di-n-propyl-dl-isoglutamin (proglumide) with 1-(3-chloropropyl)-4-(2-hydroxyethyl)-piperazine obtained from 1-(2-hydroxyethyl)piperazine and 1-bromo-3-chloropropane by means of sodium methanolate in DMSO at 105?C gives N--N_x0002_-(2-hydroxyethyl) piperazine, which is then condensated with Indomethacin (1-(p-chlorobenzoyl)- 5-methoxy-2-methylindole-3-acetic acid) by means of dicyclohexylcabodiimide and NaHCO3 in ethyl acetate .

in vivo

Proglumetacin (Sprague-Dawley rats, 0-30 mg/kg, Orally, once) dose-dependently inhibits accumulation of pouch exudate[1].

Animal Model:Sprague-Dawley rats (6 weeks)
Dosage:0, 0.3, 3, 9, 30 mg/kg
Administration:Orally, once
Result:Caused dose-dependent reduction of leukocyte migration into the pouch exudate, caused 49.2% inhibition at 30 mg/kg; and markedly decreased the prostaglandin E2 content of the pouch exudate, but tended to increase the leukotriene B 4 content.

PROGLUMETACIN MALEATE Preparation Products And Raw materials

Raw materials

Preparation Products

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PROGLUMETACIN MALEATE Suppliers

China 13 Europe 1 India 1 United Kingdom 2 United States 7 Global 24
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
6387
Advantage
52
Wuhan Dahua Pharmaceutical Co., Ltd.
Tel
027-59262863 13277907145 3091977954
Fax
027-59420980
Country
China
ProdList
4942
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Shenzhen SUNGENING Bio-Medical Co., Ltd.
Tel
0755-0755-28967200-8062 13631290199
Fax
0755-28967200
Email
wxf@sungening.com
Country
China
ProdList
9624
Advantage
60
Capot Chemical Co.,Ltd.
Tel
+86-（0）57185586718; +8613336195806
Fax
+86-571-85864795
Email
sales@capot.com
Country
China
ProdList
29735
Advantage
60
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57422
Advantage
58
Santa Cruz Biotechnology Inc
Tel
021-60936350
Email
scbt@scbt.com
Country
China
ProdList
6594
Advantage
58

57132-53-3, PROGLUMETACIN MALEATERelated Search:

Ethyl 3-indoleacetate PROGLUMETACIN MALEATE 5-Methoxyindole-3-acetic acid 1-METHYL-3-INDOLEACETIC ACID 5-HYDROXYINDOLE-3-ACETIC ACID 5-METHOXY-2-METHYL-3-INDOLEACETIC ACID 2-METHYLINDOLE-3-ACETIC ACID Indometacin 1-Acetyl-5-methoxyindole Delmetacin 5-HYDROXYTRYPTOPHOL 5-METHOXYTRYPTOPHOL Proglumide 1-Ethyl-5-methoxyindole 1-METHYLINDOLE-3-ACETIC ACID ETHYL ESTER 1-[2-(1-PROPYL)-OXYETHYL]-PIPERAZINE ETHYL 2-METHYL-3-INDOLEACETATE (5-METHOXY-2-METHYL-1H-INDOL-3-YL)-ACETIC ACID ETHYL ESTER

  • PROGLUMETACIN
  • PROGLUMETACIN MALEATE
  • Proglumetacine
  • 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 2-[4-[3-[[4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl]oxy]propyl]-1-piperazinyl]ethyl ester (9CI)
  • 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 2-[4-[3-[[4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl]oxy]propyl]-1-piperazinyl]ethyl ester, (+-)-
  • 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid 2-[4-[3-[[4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl]oxy]propyl]-1-piperazinyl]ethyl ester
  • 57132-53-3
  • 59209-48-4
  • C46H58ClN5O8