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Fumed Silica

Product Name
Fumed Silica
CAS No.
112945-52-5
Chemical Name
Fumed Silica
Synonyms
COLLOIDAL SILICA;SAND;ludox;SILICA GEL 60;Nanometer;dicalite;SILICA GEL DESICCANT;IATROBEADS;SILICA STANDARD;SILICA GEL ORANGE
CBNumber
CB9199390
Molecular Formula
O2Si
Formula Weight
60.08
MOL File
112945-52-5.mol
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Fumed Silica Property

Melting point:
>1600°C
Density 
2.3 lb/cu.ft at 25 °C (bulk density)(lit.)
refractive index 
n20/D 1.46(lit.)
solubility 
Practically insoluble in organic solvents, water, and acids, except hydrofluoric acid; soluble in hot solutions of alkali hydroxide. Forms a colloidal dispersion with water. For Aerosil, solubility in water is 150 mg/L at 258℃ (pH 7).
form 
powder
Specific Gravity
2.2
Hydrolytic Sensitivity
5: forms reversible hydrate
InChI
InChI=1S/O2Si/c1-3-2
InChIKey
VYPSYNLAJGMNEJ-UHFFFAOYSA-N
SMILES
[Si](=O)=O
CAS DataBase Reference
112945-52-5(CAS DataBase Reference)
EPA Substance Registry System
Silica, amorphous, fumed, cryst.-free (112945-52-5)
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Safety

Safety Statements 
24/25
WGK Germany 
2
RTECS 
VV7310000
TSCA 
Yes
HS Code 
28112290
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H350May cause cancer

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
381276
Product name
Silica
Purity
99.8%
Packaging
100g
Price
$45.1
Updated
2024/03/01
Sigma-Aldrich
Product number
381276
Product name
Silica
Purity
99.8%
Packaging
500g
Price
$91.6
Updated
2024/03/01
Strem Chemicals
Product number
14-6100
Product name
High Surface area Silica nanoparticles, Large, particle size ~900-1000 nm, surface area ~700 m2/g, (KCC-1 L1)
Packaging
1g
Price
$60
Updated
2024/03/01
Strem Chemicals
Product number
14-6100
Product name
High Surface area Silica nanoparticles, Large, particle size ~900-1000 nm, surface area ~700 m2/g, (KCC-1 L1)
Packaging
5g
Price
$233
Updated
2024/03/01
Sigma-Aldrich
Product number
S5505
Product name
Silica, fumed
Purity
powder, 0.2-0.3 μm avg. part. size (aggregate)
Packaging
100g
Price
$55.7
Updated
2024/03/01
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Fumed Silica Chemical Properties,Usage,Production

Chemical Properties

Amorphous silica, the noncrystalline form of SiO2, is a transparent to gray, odorless, amorphous powder

Chemical Properties

Colloidal silicon dioxide is a submicroscopic fumed silica with a particle size of about 15 nm. It is a light, loose, bluish-white-colored, odorless, tasteless, amorphous powder.

Uses

Synthetic Amorphous Silica has interesting thickening and thixotropic properties, and an enormous external surface area. It is produced by a vapor phase hydrolysis process using chlorosilanes or substituted silanes such as, silicon tetrachloride in a flame of hydrogen and oxygen. This material is formed and collected in a dry state. This product contains no detectable crystalline silica.

Production Methods

Colloidal silicon dioxide is prepared by the flame hydrolysis of chlorosilanes, such as silicon tetrachloride, at 18008℃ using a hydrogen–oxygen flame. Rapid cooling from the molten state during manufacture causes the product to remain amorphous.

Definition

ChEBI: Silicon dioxide is a silicon oxide made up of linear triatomic molecules in which a silicon atom is covalently bonded to two oxygens.

General Description

Fumed silica may be synthesized by high temperature hydrolysis of SiCl4 in O2(N2)/H2 flame. It is amorphous in nature and possesses very high specific area. The micro droplets of amorphous silica fuse into a branch and form a chain like agglomerate.

Pharmaceutical Applications

Colloidal silicon dioxide is widely used in pharmaceuticals, cosmetics, and food products. Its small particle size and large specific surface area give it desirable flow characteristics that are exploited to improve the flow properties of dry powders in a number of processes such as tableting and capsule filling.
Colloidal silicon dioxide is also used to stabilize emulsions and as a thixotropic thickening and suspending agent in gels and semisolid preparations. With other ingredients of similar refractive index, transparent gels may be formed. The degree of viscosity increase depends on the polarity of the liquid (polar liquids generally require a greater concentration of colloidal silicon dioxide than nonpolar liquids). Viscosity is largely independent of temperature. However, changes to the pH of a system may affect the viscosity1.
In aerosols, other than those for inhalation, colloidal silicon dioxide is used to promote particulate suspension, eliminate hard settling, and minimize the clogging of spray nozzles. Colloidal silicon dioxide is also used as a tablet disintegrant and as an adsorbent dispersing agent for liquids in powders. Colloidal silicon dioxide is frequently added to suppository formulations containing lipophilic excipients to increase viscosity, prevent sedimentation during molding, and decrease the release rate. Colloidal silicon dioxide is also used as an adsorbent during the preparation of wax microspheres; as a thickening agent for topical preparations; and has been used to aid the freeze-drying of nanocapsules and nanosphere suspensions.

Safety Profile

Poison by intraperitoneal, intravenous, and intratracheal routes. Moderately toxic by ingestion. An inhalation hazard. Much less toxic than crystalhe forms. Questionable carcinogen with experimental carcinogenic data. Mutation data reported. Does not cause silicosis. See also other silica entries

Safety

Colloidal silicon dioxide is widely used in oral and topical pharmaceutical products and is generally regarded as an essentially nontoxic and nonirritant excipient. However, intraperitoneal and subcutaneous injection may produce local tissue reactions and/or granulomas. Colloidal silicon dioxide should therefore not be administered parenterally.
LD50 (rat, IV): 0.015 g/kg
LD50 (rat, oral): 3.16 g/kg

Potential Exposure

Amorphous fumed silica is used as a mineral, natural or synthetic fiber. A potential danger to those involved in the production and handling of fumed silica for paint pigments or catalysts. Diatomaceous earth is used in clarifying liquids, in manufacture of fire brick and heat insulators; used as a filtering agent; as a filler in construction materials; pesticides, paints, and varnishes. A potential danger to those involved in mining of diatomaceous earth or fabrication of products there from.

storage

Colloidal silicon dioxide is hygroscopic but adsorbs large quantities of water without liquefying. When used in aqueous systems at a pH 0–7.5, colloidal silicon dioxide is effective in increasing the viscosity of a system. However, at a pH greater than 7.5 the viscosityincreasing properties of colloidal silicon dioxide are reduced; and at a pH greater than 10.7 this ability is lost entirely since the silicon dioxide dissolves to form silicates. Colloidal silicon dioxide powder should be stored in a well-closed container.

Purification Methods

Purification of silica for high technology applications uses isopiestic vapour distillation from concentrated volatile acids and is absorbed in high purity water. The impurities remain behind. Preliminary cleaning to remove surface contaminants uses dip etching in HF or a mixture of HCl, H2O2 and deionised water [Phelan & Powell Analyst 109 1299 1984].

Incompatibilities

Silica, amorphous is a noncombustible solid. Generally unreactive chemically. Incompatible with fluorine, oxygen difluoride, chlorine trifluoride. Soluble in molten alkalis and reacts with most metallic oxides at high temperature.

Incompatibilities

Incompatible with diethylstilbestrol preparations.

Toxics Screening Level

The initial threshold screening level (ITSL) for the amorphous silica compounds listed above is 60 μg/m3 based on an 8-hour averaging time.

Waste Disposal

Sanitary landfill.

Regulatory Status

GRAS listed. Included in the FDA Inactive Ingredients Database (oral capsules, suspensions, and tablets; transdermal, rectal, and vaginal preparations). Also approved by the FDA as a food additive and for food contact. Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

Fumed Silica Preparation Products And Raw materials

Raw materials

Sulfuric acid

Preparation Products

piling adhesive YH-891 1-OCTADECENE Silicon carbide Magnesium fluorosilicate LEAD SILICOCHROMATE Hexafluorosilicic acid Premixing agent Porcelain glaze,industrial Sodium silicate Silica glass Sodium fluorosilicate SODIUM METASILICATE PENTAHYDRATE Sodium fluoride Potassium silicate Calcium phosphate dibasic dihydrate
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Fumed Silica Suppliers

Australia 1 Belgium 1 Canada 3 China 274 Czech Republic 1 Europe 2 France 1 Germany 2 India 16 Japan 1 Singapore 1 Switzerland 1 United Kingdom 4 United States 34 Global 342
BOC Sciences
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1-631-485-4226; 16314854226
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Alfa Chemistry
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1-516-927-0118
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Info@alfa-chemistry.com
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Aladdin Scientific
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+1-+1(833)-552-7181
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sales@aladdinsci.com
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United States
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52924
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58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
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sales@aladdinsci.com
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57505
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Miles Chemical
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cs@mileschemical.com
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United States Biological
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chemicals@usbio.net
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Charkit Chemical Corporation
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ECSA Chemicals
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marketing@ecsa.ch
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American International Chemical, Inc.
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Strem Chemicals, Inc.
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Riedel-de Haen AG
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Alfa Chemistry
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Gelest, Inc.
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2A PharmaChem USA
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DuPont Specialty Colorants & Additives
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3B Scientific Corporation
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Ikeda Industries Corporation
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BISCO, Inc.
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Sciencelab.com, Inc.
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AMRESCO Inc.
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Regis Technologies, Inc.
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EMD Chemicals Inc.
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Mallinckrodt Baker, Inc.
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Spectrum Chemicals & Laboratory Products
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Pfaltz & Bauer, Inc.
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ProChem, Inc.
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Electron Microscopy Sciences
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Polysciences, Inc.
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Alltech Associates, Inc.
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Ricca Chemical Company
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Reade Advanced Materials
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Wilshire Chemical Company Inc.
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Pechiney
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View Lastest Price from Fumed Silica manufacturers

ChemFine International Co.,Ltd.
Product
Fumed Silica 112945-52-5
Price
US $67.00-45.00/KG
Min. Order
25KG
Purity
99%
Supply Ability
10000 KG
Release date
2024-07-19
Hebei Dangtong Import and export Co LTD
Product
Silica, fumed 112945-52-5
Price
US $9552.00/Tons
Min. Order
10Tons
Purity
99.99%
Supply Ability
100Tons
Release date
2023-03-17
Hangzhou Hyper Chemicals Limited
Product
Fumed Silica 112945-52-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%, USP
Supply Ability
1,000KG
Release date
2024-05-22

112945-52-5, Fumed SilicaRelated Search:

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  • THE(R) DESICCANT
  • diketosilane
  • Silica,Silica, fumed, Silica, Silicic anhydride, Silicon dioxide amorphous, Silicon dioxide
  • Silica, fuMed powder, 0.007 MuM
  • Silica, fuMed powder, 0.2-0.3 MuM avg. part. size (aggregate)
  • Monodisperse silica microspheres
  • Nanometer
  • Silica, powder, 200 Mesh
  • Aerosil R 8200 hydrophobic fumed silica (SiO2)
  • Aerosil380 Hydrophilic fumed silica (SiO2)
  • AerosilMOX 170 Hydrophilic fumed mixed oxide (SiO2+Al2O3)
  • HDK N20 hydrophobic fumed silica (SiO2)
  • HDK T40 HYDROPHILIC PYROGENIC SILICA
  • Hydrophilic fumed silica hydrophilic (SiO2)
  • hydrophobic fumed silica (SiO2)