S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt

ChemicalBook > CAS DataBase List > S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt

S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt

Product Name: S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt
CAS No.: 136676-91-0
Chemical Name: S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt
Synonyms: PD 123319 bis(trifluoroacetate);PD 123319 (trifluoroacetate salt);PD123319; PD-123319; S-+-PD 123319;PD 123319 DITRIFLUOROACETATE, CID: 6604951;PD 123,319 di(trifluoroacetate) salt hydrate;PD 123,319 hydrate di(trifluoroacetate) salt;PD 123,319 di(trifluoroacetate) salt hydrate powder, >=98% (HPLC);PD123319 di(trifluoroacetate), angiotensin AT2 receptor antagonist;(S)-1-[[4-(Dimethylamino)-3-methylphenyl]methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid bis(trifluoroacetate);S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid di(trifluoroacetate) salt hydrate
CBNumber: CB92100002
Molecular Formula: C33H33F3N4O5
Formula Weight: 622.65
MOL File: 136676-91-0.mol

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S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt Property

storage temp.: 2-8°C
solubility: H2O: soluble10mg/mL, clear
form: powder
color: White to yellow
Water Solubility: Soluble to 100 mM in water

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P186
Product name: PD 123,319 di(trifluoroacetate) salt hydrate
Purity: powder, ≥98% (HPLC)
Packaging: 10mg
Price: $410
Updated: 2024/03/01

Cayman Chemical

Product number: 16099
Product name: PD 123319 (trifluoroacetate salt)
Purity: ≥98%
Packaging: 5mg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 16099
Product name: PD 123319 (trifluoroacetate salt)
Purity: ≥98%
Packaging: 10mg
Price: $175
Updated: 2024/03/01

Cayman Chemical

Product number: 16099
Product name: PD 123319 (trifluoroacetate salt)
Purity: ≥98%
Packaging: 25mg
Price: $385
Updated: 2024/03/01

Cayman Chemical

Product number: 16099
Product name: PD 123319 (trifluoroacetate salt)
Purity: ≥98%
Packaging: 50mg
Price: $672
Updated: 2024/03/01

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S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt Chemical Properties,Usage,Production

Uses

PD123,319 di (trifluoroacetate) salt hydrate has been used in following experimental studies:

To determine the effect of Angiotensin II (Ang II) on alveolar fluid clearance (AFC).
To study the effect of PD123319 on AngII-induced abdominal aortic aneurysms (AAAs).
To study its effect on Ang II-induced LRP1 overexpression and function in vascular smooth muscle cells (VSMCs) culture.

Biological Activity

PD 123319 ditrifluoroacetate is a potent and selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.

in vitro

PD 123319 is shown to discriminate between two subclasses of AII receptors in many different tissues. ¹²⁵ I-AII specifically label two classes of binding sites for AII in a membrane preparation of bovine adrenal glomerulosa cells. The first class (DuP-753 sensitive) represents approximately 85% of the total binding sites for AII and possesses a high affinity (IC ₅₀ of 92.9 nM) for DuP-753. PD-123319 does not have any effect on ¹²⁵ I-AII binding to this site. The second class of binding sites is more sensitive to PD-123319, with an IC ₅₀ of 6.9 nM , and has a much lower affinity for DuP-753 (IC ₅₀ around 10 microM).

target

IC50: 34 nM (AT2 Receptor)

storage

Store at -20°C

S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt manufacturers

Career Henan Chemical Co

Product: S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt 136676-91-0
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-13

136676-91-0, S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) saltRelated Search:

(aR,3aS,4S,6S,7aR)-Hexahydro-3a,8,8-trimethyl-alpha-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate Trifluoroacetic acid Pyridine trifluoroacetate Potassium phthalimide

(S)-1-[[4-(Dimethylamino)-3-methylphenyl]methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid bis(trifluoroacetate)

PD 123319 bis(trifluoroacetate)

PD 123,319 hydrate di(trifluoroacetate) salt

S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt

PD123319; PD-123319; S-+-PD 123319

PD 123,319 di(trifluoroacetate) salt hydrate

S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid di(trifluoroacetate) salt hydrate

PD 123319 (trifluoroacetate salt)

PD 123319 DITRIFLUOROACETATE, CID: 6604951

PD 123,319 di(trifluoroacetate) salt hydrate powder, >=98% (HPLC)

(S)-1-(4-(Dimethylamino)-3-methylbenzyl)-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid compound with 2,2,2-trifluoroacetic acid (1:2)

PD123319 di(trifluoroacetate), angiotensin AT2 receptor antagonist

136676-91-0

C31H32N4O32C2HF3O2

C35H34F6N4O7