TRIAZOXIDE Property

Melting point:

178-182 °C

Boiling point:

533.4±42.0 °C(Predicted)

Density 

1?+-.0.1 g/cm3(Predicted)

vapor pressure 

1 x 10^-7 Pa (20 °C)

Flash point:

>100 °C

Water Solubility 

34 mg l^-1 (20 °C)

pka

-0.16±0.10(Predicted)

BRN 

617803

EPA Substance Registry System

1,2,4-Benzotriazine, 7-chloro-3-(1H-imidazol-1-yl)-, 1-oxide (72459-58-6)

Safety

Hazard Codes 

T

Risk Statements 

23/25

Safety Statements 

45

RIDADR 

UN2811 6.1/PG 1

WGK Germany 

3

HS Code 

29333990

Toxicity

LD50 in rats (mg/kg): >5000 dermally; 100-200 orally; LC50 (4hr) in rats (mg/l): 0.8-3.2 by inhalation (Dutzmann)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

TRIAZOXIDE Chemical Properties,Usage,Production

Uses

Triazoxide is used as a seed dressing for the control of seed-borne diseases in winter and spring barley.

Uses

Triazoxide is a pesticide.

Uses

Fungicide.

Definition

ChEBI: A member of the class of benzotriazines that is 1,2,4-benzotriazine 1-oxide which is substituted by chlorine at position 7 and by a 1H-imidazol-1-yl group at position 3. A fungicide, it is used as a seed treatment for control of seed-bor e Pyrenophora graminea and Pyrenophora teres in barley.

Metabolic pathway

Triazoxide was the subject of an evaluation by the Pesticide Safety Directorate of UK MAFF. The information presented below was obtained from this source (PSD, 1994). The specific use of triazoxide (seed treatment) gives rise to very low residues and therefore the metabolic pathways in plants were not investigated. The compound is rather persistent in soils and sediments but it is likely to be short-lived in water owing to photolysis. Much is known about the absorption, distribution and elimination of the compound in rat but only one metabolite, of apparently many, was identified. The use pattern and consequent negligible residues in plants did not warrant studies in nuninants and poultry.

Degradation

Triazoxide is very stable in water with extrapolated DT₅₀ values of well over 1 year at pH 4 and 7, and 23 days at pH 9. Aqueous photolysis is expected to be more important under environmental conditions; the DT₅₀ was 2-14 days at latitude 50" depending on the season. On a silica surface, triazoxide was 95% degraded in 7 days when irradiated with a fluorescent lamp. Details of the products were not reported.