ChemicalBook > CAS DataBase List > 4-BROMO-2-FORMYLTHIAZOLE
4-BROMO-2-FORMYLTHIAZOLE
- Product Name
- 4-BROMO-2-FORMYLTHIAZOLE
- CAS No.
- 167366-05-4
- Chemical Name
- 4-BROMO-2-FORMYLTHIAZOLE
- Synonyms
- thiazol-4-ol;4-BROMO-2-FORMYLTHIAZOLE;2-Formyl-4-bromo-1,3-thiazole;4-Bromo-2-thiazolecarbaldehyde;4-Bromo-thiazol-2-carbaldehyde;4-Bromo-2-thiazolecarboxaldehyde;2-Thiazolecarboxaldehyde,4-broMo-;4-broMo-1,3-thiazole-2-carbaldehyde;4-Bromothiazole-2-carboxaldehyde 96%;4-Bromo-1,3-thiazole-2-carboxaldehyde
- CBNumber
- CB92130016
- Molecular Formula
- C4H2BrNOS
- Formula Weight
- 192.03
- MOL File
- 167366-05-4.mol
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4-BROMO-2-FORMYLTHIAZOLE Property
- Melting point:
- 66-70℃
- Boiling point:
- 288℃
- Density
- 1.920
- Flash point:
- 128℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder
- pka
- -2.33±0.10(Predicted)
- InChI
- InChI=1S/C4H2BrNOS/c5-3-2-8-4(1-7)6-3/h1-2H
- InChIKey
- JDUXMFGFGCJNGO-UHFFFAOYSA-N
- SMILES
- S1C=C(Br)N=C1C=O
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 699284
- Product name
- 4-Bromothiazole-2-carboxaldehyde
- Purity
- 96%
- Packaging
- 1g
- Price
- $151
- Updated
- 2023/06/20
TRC
- Product number
- B699460
- Product name
- 4-Bromo-2-formylthiazole
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
Frontier Specialty Chemicals
- Product number
- B1728
- Product name
- 4-Bromo-2-formylthiazole
- Purity
- 98%
- Packaging
- 1g
- Price
- $19
- Updated
- 2021/12/16
Frontier Specialty Chemicals
- Product number
- CAPOB1728
- Product name
- 4-Bromo-2-formylthiazole
- Purity
- 98%
- Packaging
- 1g
- Price
- $19
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 7H70-9-Z4
- Product name
- 4-Bromo-1,3-thiazole-2-carboxaldehyde
- Packaging
- 250mg
- Price
- $32
- Updated
- 2021/12/16
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4-BROMO-2-FORMYLTHIAZOLE Chemical Properties,Usage,Production
Synthesis
4394-85-8
4175-77-3
167366-05-4
GENERAL PROCEDURE: The reaction was carried out in a sealed tube under nitrogen atmosphere using tetrahydrofuran (4 mL) as solvent. To a solution of tert-butyl 2-bromothiazole-4-carboxylate (1a, 0.397 mmol) was slowly added isopropylmagnesium chloride/lithium chloride complex (1.3 M, 0.52 mmol) dropwise at -78 °C. After 15 min of reaction, the corresponding aldehyde (0.79-0.99 mmol) or N-formylmorpholine (used for the synthesis of 2-formylthiazoles 3a-b) was added dropwise with continuous stirring and the reaction mixture was continued to be stirred at -78°C for 10 min, followed by warming up to 0°C for 1.5 h of reaction. Upon completion of the reaction, the reaction was quenched by the addition of saturated aqueous ammonium chloride and the aqueous phase was extracted with ether (3 x 10 mL). The combined organic phases were washed sequentially with 5% aqueous hydrochloric acid (10 mL), saturated saline (10 mL), dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel fast column chromatography using mixed solvent of ethyl acetate/petroleum ether as eluent (see below for the specific ratio) to obtain tert-butyl 2-(1-hydroxymethyl)thiazole-4-carboxylate derivatives (rac-2a-h).
References
[1] Tetrahedron Asymmetry, 2012, vol. 23, # 6-7, p. 474 - 481
4-BROMO-2-FORMYLTHIAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-BROMO-2-FORMYLTHIAZOLE manufacturers
Henan Fengda Chemical Co., Ltd
- Product
- 4-BROMO-2-FORMYLTHIAZOLE 167366-05-4
- Price
- US $8.00-6.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-23
Career Henan Chemical Co
- Product
- 4-BROMO-2-FORMYLTHIAZOLE 167366-05-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-07-02
167366-05-4, 4-BROMO-2-FORMYLTHIAZOLERelated Search:
1,3-Thiazole-2-carbaldehyde
4-BROMO-1,3-THIAZOLE-2-CARBOXYLIC ACID
4-Bromothiazole
ETHYL 4-BROMOTHIAZOLE-2-CARBOXYLATE
4-BROMO-2-METHYLTHIAZOLE
4-BROMO-2-FORMYLTHIAZOLE