EFONIDIPINE

Product Name: EFONIDIPINE
CAS No.: 111011-63-3
Chemical Name: EFONIDIPINE
Synonyms: EFONIDIPINE;Efonidipine(NZ-105);EFONIDIPINE FREE BASE;Efonidipine, 10 mM in DMSO;NZ105,Inhibitor,Ca channels,inhibit,Calcium Channel,NZ 105,Efonidipine,Ca2+ channels;2-(N-benzylanilino)ethyl 5-(5,5-dimethyl-2-oxo-1,3,2λ5-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate;2-(Benzyl(phenyl)amino)ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate;2-(N-benzylanilino)ethyl 5-(5,5-dimethyl-2-oxo-1,3,2λ⁵-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate;5,5-Dimethyl-2-[[1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-5-[[2-[phenyl(phenylmethyl)amino]ethoxy]carbonyl]pyridin]-3-yl]-1,3,2-dioxaphosphorinane 2-oxide;5-(5,5-Dimethyl-2-oxo-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylic acid 2-[phenyl(phenylmethyl)amino]ethyl ester
CBNumber: CB92130511
Molecular Formula: C34H38N3O7P
Formula Weight: 631.66
MOL File: 111011-63-3.mol

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EFONIDIPINE Property

Melting point:: 169-170℃
Boiling point:: 746.9±60.0 °C(Predicted)
Density: 1.30±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF:30.0(Max Conc. mg/mL);47.49(Max Conc. mM)
Ethanol:40.0(Max Conc. mg/mL);63.32(Max Conc. mM)
form: A crystalline solid
pka: 4.03±0.50(Predicted)
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0005025
Product name: EFONIDIPINE
Purity: 95.00%
Packaging: 10MG
Price: $224.7
Updated: 2021/12/16

CSNpharm

Product number: CSN16302
Product name: Efonidipine
Packaging: 50mg
Price: $307
Updated: 2021/12/16

DC Chemicals

Product number: DC23624
Product name: Efonidipine
Purity: >98%
Packaging: 1g
Price: $1600
Updated: 2021/12/16

Crysdot

Product number: CD31004556
Product name: Efonidipine
Purity: 98+%
Packaging: 10mg
Price: $56
Updated: 2021/12/16

Chemenu

Product number: CM172430
Product name: 2-(benzyl(phenyl)amino)ethyl5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate
Purity: 98%
Packaging: 50mg
Price: $209
Updated: 2021/12/16

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EFONIDIPINE Chemical Properties,Usage,Production

Uses

Efonidipine(NZ-105) is a dual T-type and L-type calcium channel blocker (CCB). IC50 value: Target: calcium channel blocker in vitro: Efonidipine and nifedipine, but not other examined CCBs, also increased the N(6), 2'-O-dibutyryladenosine 3',5'-cyclic monophosphate (dbcAMP)-induced StAR mRNA, which reflects the action of adrenocorticotropic hormone, and efonidipine and R(-)-efonidipine enhanced the dbcAMP-induced DHEA-S production in NCI-H295R adrenocortical carcinoma cells [1]. I(Ca(T)) was blocked mainly by a tonic manner by nifedipine, by a use-dependent manner by mibefradil, and by a combination of both manners by efonidipine. IC50s of these Ca2+ channel antagonists to I(Ca(T)) and L-type Ca2+ channel current (I(Ca(L))) were 1.2 micromol/l and 0.14 nmol/l for nifedipine; 0.87 and 1.4 micromol/l for mibefradil, and 0.35 micromol/l and 1.8 nmol/l for efonidipine, respectively [4]. in vivo: Twenty hypertensive patients on chronic hemodialysis were given efonidipine 20-60 mg twice daily and amlodipine 2.5-7.5 mg once daily for 12 weeks each in a random crossover manner. The average blood pressure was comparable between the efonidipine and amlodipine periods (151 + or - 15/77 + or - 8 versus 153 + or - 15/76 + or - 8 mmHg). The pulse rate did not change significantly during the administration periods [2]. In the UM-X7.1 group, EFO treatment significantly attenuated the decrease of LVEF without affecting blood pressure compared with the vehicle group. EFO treatment decreased heart rate (by approximately 10%) in both groups [3].

Definition

ChEBI: 2-[benzyl(phenyl)amino]ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate is a carboxylic ester resulting from the formal condensation of the carboxy group of 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid with the hydroxy group of 2-[benzyl(phenyl)amino]ethanol. It is a C-nitro compound, a carboxylic ester, a tertiary amino compound and a dihydropyridine.

References

[1] Ikeda K, et al. Efonidipine, a Ca(2+)-channel blocker, enhances the production of dehydroepiandrosterone sulfate in NCI-H295R human adrenocortical carcinoma cells. Tohoku J Exp Med. 2011;224(4):263-71. DOI:10.1620/tjem.224.263
[2] Nakano N, et al. Effects of efonidipine, an L- and T-type calcium channel blocker, on the renin-angiotensin-aldosterone system in chronic hemodialysis patients. Int Heart J. 2010 May;51(3):188-92. DOI:10.1536/ihj.51.188
[3] Suzuki S, et al. Beneficial effects of the dual L- and T-type Ca2+ channel blocker efonidipine on cardiomyopathic hamsters. Circ J. 2007 Dec;71(12):1970-6. DOI:10.1253/circj.71.1970
[4] Lee TS, et al. Actions of mibefradil, efonidipine and nifedipine block of recombinant T- and L-type Ca channels with distinct inhibitory mechanisms. Pharmacology. 2006;78(1):11-20. DOI:10.1159/000094900

EFONIDIPINE Preparation Products And Raw materials

Raw materials

Preparation Products

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EFONIDIPINE Suppliers

China 66 India 2 United States 7 Global 75

Shanghai Boyle Chemical Co., Ltd.

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Shanghai Hanhong Scientific Co.,Ltd.

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Nanjing Sunlida Biological Technology Co., Ltd.

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Taizhou Tongxin Bio-Tech Co., Ltd

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Country: China
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LETOPHARM LIMITED

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Shanghaizehan biopharma technology co., Ltd.

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Shanghai Synchem Pharma Co., ltd

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Taizhou Ruixin Chemical Co., Ltd.

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Shanghai YuanYe Biotechnology Co., Ltd.

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Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
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View Lastest Price from EFONIDIPINE manufacturers

Career Henan Chemical Co

Product: EFONIDIPINE 111011-63-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: g/kg/Ton
Release date: 2019-12-25

111011-63-3, EFONIDIPINERelated Search:

4-PHOSPHONOBUTYRIC ACID PAK 200 DIMETHYL VINYLPHOSPHONATE EFONIDIPINE HCL (2-phenylethyl)phosphonic acid 2-METHYLVINYLPHOSPHONIC ACID ISOBUTYL HYDROGEN METHYLPHOSPHONATE EFONIDIPINE

EFONIDIPINE

5-(5,5-Dimethyl-2-oxo-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylic acid 2-[phenyl(phenylmethyl)amino]ethyl ester

2-(N-benzylanilino)ethyl 5-(5,5-dimethyl-2-oxo-1,3,2λ5-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate

5,5-Dimethyl-2-[[1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-5-[[2-[phenyl(phenylmethyl)amino]ethoxy]carbonyl]pyridin]-3-yl]-1,3,2-dioxaphosphorinane 2-oxide

EFONIDIPINE FREE BASE

Efonidipine(NZ-105)

2-(N-benzylanilino)ethyl 5-(5,5-dimethyl-2-oxo-1,3,2λ<sup>5</sup>-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate

3-Pyridinecarboxylic acid, 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[phenyl(phenylmethyl)amino]ethyl ester

NZ105,Inhibitor,Ca channels,inhibit,Calcium Channel,NZ 105,Efonidipine,Ca2+ channels

2-(Benzyl(phenyl)amino)ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate

Efonidipine, 10 mM in DMSO

111011-63-3

Inhibitors