EFONIDIPINE HCL

Product Name: EFONIDIPINE HCL
CAS No.: 111011-53-1
Chemical Name: EFONIDIPINE HCL
Synonyms: EFONIDIPINE HCL;EFONIDIPINE HCL ETHANOL;Efonidipine hydrochloride;2-(N-benzylanilino)ethyl5-(5,5-dimethyl-2-oxo-1,3,2λsup5sup-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate,hydrochloride;3-Pyridinecarboxylicacid,5-(5,5-diMethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-diMethyl-4-(3-nitrophenyl)-,2-[phenyl(phenylMethyl)aMino]ethyl ester, hydrochloride (1:1)
CBNumber: CB4847445
Molecular Formula: C34H38N3O7P.ClH
Formula Weight: 668.123
MOL File: 111011-53-1.mol

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EFONIDIPINE HCL Property

storage temp.: Store at -20°C
solubility: DMSO : 8.5 mg/mL (12.72 mM)

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Safety

Toxicity: LD50 in mice (mg/kg): >600 orally (Seto)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: OPC0000544
Product name: 3-PYRIDINECARBOXYLIC ACID, 5-(5,5-DIMETHYL-1,3,2-DIOXAPHOSPHORINAN-2YL)-1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-, 2-[PHENYL(PHENYLMETHYL)AMINO]ETHYL ESTER, P-OXIDE, MONOHYDROCHLORIDE
Purity: 95.00%
Packaging: 5MG
Price: $502.77
Updated: 2021/12/16

Crysdot

Product number: CD31004557
Product name: Efonidipinehydrochloride
Purity: 98+%
Packaging: 10mg
Price: $55
Updated: 2021/12/16

Chemenu

Product number: CM176366
Product name: 2-(benzyl(phenyl)amino)ethyl5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylatehydrochloride
Purity: 98%
Packaging: 50mg
Price: $209
Updated: 2021/12/16

Crysdot

Product number: CD31004557
Product name: Efonidipinehydrochloride
Purity: 98+%
Packaging: 50mg
Price: $222
Updated: 2021/12/16

DC Chemicals

Product number: DC23612
Product name: Efonidipinehydrochloride
Purity: >98%
Packaging: 1g
Price: $1600
Updated: 2021/12/16

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EFONIDIPINE HCL Chemical Properties,Usage,Production

Uses

Efonidipine Hcl (NZ-105) is a dual T-type and L-type calcium channel blocker (CCB). IC50 value: Target: calcium channel blocker in vitro: Efonidipine and nifedipine, but not other examined CCBs, also increased the N(6), 2'-O-dibutyryladenosine 3',5'-cyclic monophosphate (dbcAMP)-induced StAR mRNA, which reflects the action of adrenocorticotropic hormone, and efonidipine and R(-)-efonidipine enhanced the dbcAMP-induced DHEA-S production in NCI-H295R adrenocortical carcinoma cells [1]. I(Ca(T)) was blocked mainly by a tonic manner by nifedipine, by a use-dependent manner by mibefradil, and by a combination of both manners by efonidipine. IC50s of these Ca2+ channel antagonists to I(Ca(T)) and L-type Ca2+ channel current (I(Ca(L))) were 1.2 micromol/l and 0.14 nmol/l for nifedipine; 0.87 and 1.4 micromol/l for mibefradil, and 0.35 micromol/l and 1.8 nmol/l for efonidipine, respectively [4]. in vivo: Twenty hypertensive patients on chronic hemodialysis were given efonidipine 20-60 mg twice daily and amlodipine 2.5-7.5 mg once daily for 12 weeks each in a random crossover manner. The average blood pressure was comparable between the efonidipine and amlodipine periods (151 + or - 15/77 + or - 8 versus 153 + or - 15/76 + or - 8 mmHg). The pulse rate did not change significantly during the administration periods [2]. In the UM-X7.1 group, EFO treatment significantly attenuated the decrease of LVEF without affecting blood pressure compared with the vehicle group. EFO treatment decreased heart rate (by approximately 10%) in both groups [3].

References

[1] Ikeda K, et al. Efonidipine, a Ca(2+)-channel blocker, enhances the production of dehydroepiandrosterone sulfate in NCI-H295R human adrenocortical carcinoma cells. Tohoku J Exp Med. 2011;224(4):263-71. DOI:10.1620/tjem.224.263
[2] Nakano N, et al. Effects of efonidipine, an L- and T-type calcium channel blocker, on the renin-angiotensin-aldosterone system in chronic hemodialysis patients. Int Heart J. 2010 May;51(3):188-92. DOI:10.1536/ihj.51.188
[3] Suzuki S, et al. Beneficial effects of the dual L- and T-type Ca2+ channel blocker efonidipine on cardiomyopathic hamsters. Circ J. 2007 Dec;71(12):1970-6. DOI:10.1253/circj.71.1970
[4] Lee TS, et al. Actions of mibefradil, efonidipine and nifedipine block of recombinant T- and L-type Ca channels with distinct inhibitory mechanisms. Pharmacology. 2006;78(1):11-20. DOI:10.1159/000094900

EFONIDIPINE HCL Preparation Products And Raw materials

Raw materials

Preparation Products

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EFONIDIPINE HCL Suppliers

Canada 1 China 31 United States 4 Global 36

Chembest Research Laboratories Limited

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Shenzhen Regent Biochemical Technology Co., Ltd.

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View Lastest Price from EFONIDIPINE HCL manufacturers

Career Henan Chemical Co

Product: EFONIDIPINE HCL 111011-53-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: g/kg/Ton
Release date: 2019-12-25

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EFONIDIPINE HCL

Efonidipine hydrochloride

EFONIDIPINE HCL ETHANOL

3-Pyridinecarboxylicacid,5-(5,5-diMethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-diMethyl-4-(3-nitrophenyl)-,2-[phenyl(phenylMethyl)aMino]ethyl ester, hydrochloride (1:1)

2-(N-benzylanilino)ethyl5-(5,5-dimethyl-2-oxo-1,3,2λsup5sup-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate,hydrochloride

111011-53-1

C34H38N3O7PHCl