Naloxone hydrochloride
- Product Name
- Naloxone hydrochloride
- CAS No.
- 357-08-4
- Chemical Name
- Naloxone hydrochloride
- Synonyms
- NALOXONE HCL;narcan;en1530;Nalone;nalonee;nih7890;EN-15304;Narcanti;Naloxone hydrochlori;NALOXONE HYDROCHLORIDE
- CBNumber
- CB1409273
- Molecular Formula
- C19H22ClNO4
- Formula Weight
- 363.84
- MOL File
- 357-08-4.mol
Naloxone hydrochloride Property
- Melting point:
- 200-2050C
- RTECS
- QD2275000
- storage temp.
- 2-8°C
- solubility
- ethanol: 3.3 mg/mL stable for several months refrigerated if protected from light.
- form
- powder
- color
- white to off-white
- Water Solubility
- Soluble in water (73 mg/ml), ethanol (3.3 mg/ml), methanol (50 mg/ml) and dimethyl sulfoxide (73 mg/ml). Insoluble in ether
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months.
- CAS DataBase Reference
- 357-08-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 22-24/25-26-36/37/39-36
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- BP548
- Product name
- Naloxone hydrochloride
- Purity
- British Pharmacopoeia (BP) Reference Standard
- Packaging
- 100MG
- Price
- $257
- Updated
- 2024/03/01
- Product number
- J60013
- Product name
- Naloxone hydrochloride, 98%
- Packaging
- 100mg
- Price
- $82
- Updated
- 2023/06/20
- Product number
- J60013
- Product name
- Naloxone hydrochloride, 98%
- Packaging
- 1g
- Price
- $490
- Updated
- 2023/06/20
- Product number
- 15594
- Product name
- Naloxone (hydrochloride)
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 15594
- Product name
- Naloxone (hydrochloride)
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $120
- Updated
- 2024/03/01
Naloxone hydrochloride Chemical Properties,Usage,Production
Description
Naloxone (hydrochloride) (CRM) (Item No. ISO60191) is a certified reference material categorized as an opioid antagonist. Formulations containing naloxone have been used as antidotes for opioid overdose and the prevention of overdose. They have also been used in combination with buprenorphine (Item Nos. ISO60178 | 14025) in the treatment of opiate addiction and in pain management. This product is intended for research and forensic applications.
Chemical Properties
Crystalline Solid
Originator
Narcan,Du Pont,US,1971
Uses
Opioate antidote;
Uses
A nonspecific opiate receptor antagonist that displays anitnociceptive effects
Uses
Naloxone Hydrochloride is a specific opioid antagonist. Narcotic antagonist.
Definition
ChEBI: A hydrochloride resulting from the formal reaction of equimolar amounts of naloxone and hydrogen chloride. A specific opioid antagonist, it is used to reverse the effects of opioids, both following their use of opioids during surgery and in cases of known r suspected opioid overdose.
Manufacturing Process
10 grams of 14-hydroxydihydromorphinone (oxymorphone) was converted
into its diacetate by warming it on the steam bath with 80 cc of acetic
anhydride for about 2 hours. The acetic anhydride was removed on the water
bath under a vacuum of about 30 mm absolute pressure. The melting point of
the residue was 220°C. The residue was taken up in 100 cc of chloroform. An
equal amount by weight of cyanogen bromide was added and the mixture was
refluxed at about 60°C for about 5 hours. After refluxing, the mixture was
washed with 100 cc of a 5% aqueous hydrochloric acid solution, dried over
sodium sulfate and the chloroform removed by evaporation under a vacuum of
about 30 mm. The residue had a melting point of 240°C.
The residue was then heated at about 90°C for 16 hours on a steam bath with
300 cc of 20% aqueous hydrochloric acid solution, and treated with a small
amount, e.g., 1 gram of charcoal. The hydrochloric acid was then removed
under a vacuum of 15 mm, the residue dissolved in 30 cc of water and
precipitated by the addition of 2.4 cc of concentrated aqueous ammonia. The
precipitate was filtered off and dried. It consists of 14-
hydroxydihydronormorphinone. It is soluble in ethanol.
The 14-hydroxydihydronormorphinone was suspended in 200 cc of pure ethyl
alcohol, half its weight of sodium bicarbonate and half its weight of allyl
bromide added and the resulting mixture was refluxed at about 75°C for 48
hours. The solution was cooled, e.g., to 10°C and filtered and the alcohol
removed under a vacuum of 30 mm. The residue was dissolved in chloroform
and filtered. The chloroform was removed under a vacuum of 30 mm and the
residue was crystallized from ethylacetate. The crystallized product, N-allyl-
1,4-hydroxydihydronormorphinone, has a melting point of 184°C, is soluble in
chloroform and insoluble in petroleum ether. The yield amounts to 20% based
on the weight of the reacted 14-hydroxydihydromorphinone.
brand name
Narcan (Bristol-Myers Squibb); Narcan (Endo).
Therapeutic Function
Narcotic antagonist
Biological Activity
Opioid antagonist.
Veterinary Drugs and Treatments
Naloxone is used in veterinary medicine almost exclusively for its opiate reversal effects, but the drug is being investigated for treating other conditions (e.g., septic, hypovolemic or cardiogenic shock). Naloxone may also be employed as a test drug to see if endogenous opiate blockade will result in diminished tail chasing or other self-mutilating behaviors. It, potentially, could be useful for treating overdoses of clonidine or the CNS effects of benzodiazepines (ivermectin?), but more research is necessary before recommending its use.
Metabolism
Naloxone hydrochloride is rapidly metabolised in the liver, mainly by conjugation with glucuronic acid to naloxone-3-glucuronide, which is excreted in the urine
storage
Room temperature
References
1) Le Bourdonnec?et al., (2008),?Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as mu opioid receptor antagonists with improved opioid receptor selectivity profiles: Bioorg. Med. Chem. Lett..?18?2006 2) Boyer?et al.?(2012),?Management of opioid analgesic overdose; New Engl. J. Med.?367?146 3) Wang?et al.?(2017),?Opioids and opioid receptors orchestrate wound repair;?Transl. Res.?185?13 4) Wright and Rodgers (2013),?Low dose naloxone attenuates the pruritic but not anorectic response to rimonabant in male rats; Psychopharmacology (Berl.)?226?415
Naloxone hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Naloxone hydrochloride manufacturers
- Product
- Naloxone hydrochloride 357-08-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-25
- Product
- Naloxone hydrochloride 357-08-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 50000KG/month
- Release date
- 2024-03-18
- Product
- Naloxone hydrochloride 357-08-4
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2023-11-02