Naloxone hydrochloride dihydrate

Product Name: Naloxone hydrochloride dihydrate
CAS No.: 51481-60-8
Chemical Name: Naloxone hydrochloride dihydrate
Synonyms: NaloxonHCl-Dihydrat;Naloxone HCl dihydrate;Naloxone hydrochloride RS;NaloxonhydrochloridDihydrat;naloxone F&D version of N7758;loxone hydrochloride dihydrate;NALOXONE HYDROCHLORIDE, DIHYDRATE;Naloxone dihydrate hydrochloride;NALOXONEHYDROCHLORIDE,DIHYDRATE,USP;Naloxone hydrochloride dihydrate CRS
CBNumber: CB7409260
Molecular Formula: C19H26ClNO6
Formula Weight: 399.87
MOL File: 51481-60-8.mol

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Naloxone hydrochloride dihydrate Property

Melting point:: 182 °C (dec.)(lit.)
storage temp.: 2-8°C
solubility: ethanol: 3.3 mg/mL stable for several months refrigerated if protected from light.
form: powder
color: white to off-white
optical activity: [α]25/D 178.6°, c = 2.5 in H2O(lit.)
Merck: 13,6388
BRN: 6260807
InChIKey: TXMZWEASFRBVKY-VGCNNFRWNA-N
SMILES: [C@@]123CCN(CC=C)[C@@H]4CC5=CC=C(O)C(O[C@H]1C(CC[C@]24O)=O)=C35.O.O.Cl |&1:0,7,16,20,r|
CAS DataBase Reference: 51481-60-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22-24/25-26-36/37/39-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0000695
Product name: Naloxone for peak identification
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 5.1 mg
Price: $236
Updated: 2025/07/31

Sigma-Aldrich

Product number: N7758
Product name: Naloxone hydrochloride dihydrate
Purity: ≥98% (TLC and titration), powder
Packaging: 1g
Price: $616
Updated: 2025/07/31

Sigma-Aldrich

Product number: N7758
Product name: Naloxone hydrochloride dihydrate
Purity: ≥98% (TLC and titration), powder
Packaging: 5g
Price: $1950
Updated: 2025/07/31

Sigma-Aldrich

Product number: N0075000
Product name: Naloxone hydrochloride dihydrate
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 50 mg
Price: $236
Updated: 2025/07/31

TCI Chemical

Product number: N1254
Product name: Naloxone Hydrochloride Dihydrate
Packaging: 10MG
Price: $102
Updated: 2025/07/31

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Naloxone hydrochloride dihydrate Chemical Properties,Usage,Production

Chemical Properties

White or almost white, hygroscopic, crystalline powder.

Uses

Naloxone Hydrochloride Dihydrate is a specific opioid antagonist. Narcotic antagonist.

Uses

Antagonist (to narcotics).

brand name

Narcan (Bristol-Myers Squibb); Narcan (Endo).

Biochem/physiol Actions

Competitive antagonist for μ, κ, δ, and σ opioid receptors; blocks the action of σ-agonists at opioid sites. Naloxone′s antagonistic effect last for about 45 min and thus, requires repeated dosage. It results in critical side effects such as pulmonary edema.

Purification Methods

This opiate antagonist has been recrystallised from EtOH/Et2O or H2O. It is soluble in H2O (5%) and EtOH but insoluble in Et2O. The free base has m 184o (177-178o also reported) after recrystallisation from EtOAc, and [] D -194.5o (c 0.93, CHCl3). [Olofson et al. Tetrahedron Lett 1567 1977, Gold et al. Med Res Rev 2 211 1982.]

Naloxone hydrochloride dihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Naloxone hydrochloride dihydrate Suppliers

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Sigma-Aldrich

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View Lastest Price from Naloxone hydrochloride dihydrate manufacturers

Career Henan Chemical Co

Product: Naloxone hydrochloride dihydrate 51481-60-8
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-98%
Supply Ability: 100kg
Release date: 2018-12-15

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Naloxone HCl dihydrate

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NaloxonHCl-Dihydrat

NaloxonhydrochloridDihydrat

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Naloxone hydrochloride dihydrate CRS

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Naloxone hydrochloride dihydrate USP/EP/BP

Naloxone for peak identification (Y0000695)Q: What is Naloxone for peak identification (Y0000695) Q: What is the CAS Number of Naloxone for peak identification (Y0000695)

Naloxone hydrochloride dihydrateQ: What is Naloxone hydrochloride dihydrate Q: What is the CAS Number of Naloxone hydrochloride dihydrate Q: What is the storage condition of Naloxone hydrochloride dihydrate Q: What are the applications of Naloxone hydrochloride dihydrate

Naloxone HCl Dihydrate, 10 mM in DMSO

Naloxone Hydrochloride Dihydrate 1.0 mg/ml in Methanol (as anhydrous free base)

Naloxone.HCl.dihydrate, 1mg/ml in Methanol (as free base)

Naloxone hydrochloride RS

51481-60-8

C19H21NO4HCl2H2O

C19H26ClNO6

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