Naloxone hydrochloride dihydrate

Product Name: Naloxone hydrochloride dihydrate
CAS No.: 51481-60-8
Chemical Name: Naloxone hydrochloride dihydrate
Synonyms: NaloxonHCl-Dihydrat;Naloxone HCl dihydrate;NaloxonhydrochloridDihydrat;naloxone F&D version of N7758;loxone hydrochloride dihydrate;NALOXONE HYDROCHLORIDE, DIHYDRATE;Naloxone dihydrate hydrochloride;NALOXONEHYDROCHLORIDE,DIHYDRATE,USP;Naloxone hydrochloride dihydrate CRS;Naloxone for peak identification CRS
CBNumber: CB7409260
Molecular Formula: C19H26ClNO6
Formula Weight: 399.87
MOL File: 51481-60-8.mol

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Naloxone hydrochloride dihydrate Property

Melting point:: 182 °C (dec.)(lit.)
storage temp.: 2-8°C
solubility: ethanol: 3.3 mg/mL stable for several months refrigerated if protected from light.
form: powder
color: white to off-white
optical activity: [α]25/D 178.6°, c = 2.5 in H2O(lit.)
Merck: 13,6388
BRN: 6260807
CAS DataBase Reference: 51481-60-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22-24/25-26-36/37/39-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N7758
Product name: Naloxone hydrochloride dihydrate
Purity: ≥98% (TLC and titration), powder
Packaging: 1g
Price: $599
Updated: 2024/03/01

Sigma-Aldrich

Product number: N7758
Product name: Naloxone hydrochloride dihydrate
Purity: ≥98% (TLC and titration), powder
Packaging: 5g
Price: $760
Updated: 2024/03/01

Sigma-Aldrich

Product number: N7758
Product name: Naloxone hydrochloride dihydrate
Purity: ≥98% (TLC and titration), powder
Packaging: 250mg
Price: $185
Updated: 2024/03/01

Sigma-Aldrich

Product number: Y0000695
Product name: Naloxone for peak identification
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0000695
Price: $220
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHR1802
Product name: Naloxone hydrochloride dihydrate
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 300mg
Price: $267
Updated: 2024/03/01

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Naloxone hydrochloride dihydrate Chemical Properties,Usage,Production

Chemical Properties

White or almost white, hygroscopic, crystalline powder.

Uses

Naloxone Hydrochloride Dihydrate is a specific opioid antagonist. Narcotic antagonist.

Uses

Antagonist (to narcotics).

brand name

Narcan (Bristol-Myers Squibb); Narcan (Endo).

Biochem/physiol Actions

Competitive antagonist for μ, κ, δ, and σ opioid receptors; blocks the action of σ-agonists at opioid sites. Naloxone′s antagonistic effect last for about 45 min and thus, requires repeated dosage. It results in critical side effects such as pulmonary edema.

Purification Methods

This opiate antagonist has been recrystallised from EtOH/Et2O or H2O. It is soluble in H2O (5%) and EtOH but insoluble in Et2O. The free base has m 184o (177-178o also reported) after recrystallisation from EtOAc, and [] D -194.5o (c 0.93, CHCl3). [Olofson et al. Tetrahedron Lett 1567 1977, Gold et al. Med Res Rev 2 211 1982.]

Naloxone hydrochloride dihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Naloxone hydrochloride dihydrate Suppliers

China 70 France 2 Germany 1 India 9 Italy 1 Switzerland 2 The Netherlands 1 United Kingdom 5 United States 19 Global 110

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Sigma-Aldrich

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View Lastest Price from Naloxone hydrochloride dihydrate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Naloxone hydrochloride dihydrate 51481-60-8
Price: US $0.00-0.00/g/Bag
Min. Order: 1g
Purity: 98%-102%
Supply Ability: 1000G
Release date: 2021-07-19

Career Henan Chemical Co

Product: Naloxone hydrochloride dihydrate 51481-60-8
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-98%
Supply Ability: 100kg
Release date: 2018-12-15

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Naloxone for peak identification (Y0000695)Q: What is Naloxone for peak identification (Y0000695) Q: What is the CAS Number of Naloxone for peak identification (Y0000695)

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51481-60-8

C19H21NO4HCl2H2O

C19H26ClNO6

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