ChemicalBook > CAS DataBase List > Naloxone hydrochloride dihydrate

Naloxone hydrochloride dihydrate

Product Name
Naloxone hydrochloride dihydrate
CAS No.
51481-60-8
Chemical Name
Naloxone hydrochloride dihydrate
Synonyms
NaloxonHCl-Dihydrat;Naloxone HCl dihydrate;NaloxonhydrochloridDihydrat;naloxone F&D version of N7758;loxone hydrochloride dihydrate;NALOXONE HYDROCHLORIDE, DIHYDRATE;Naloxone dihydrate hydrochloride;NALOXONEHYDROCHLORIDE,DIHYDRATE,USP;Naloxone hydrochloride dihydrate CRS;Naloxone for peak identification CRS
CBNumber
CB7409260
Molecular Formula
C19H26ClNO6
Formula Weight
399.87
MOL File
51481-60-8.mol
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Naloxone hydrochloride dihydrate Property

Melting point:
182 °C (dec.)(lit.)
storage temp. 
2-8°C
solubility 
ethanol: 3.3 mg/mL stable for several months refrigerated if protected from light.
form 
powder
color 
white to off-white
optical activity
[α]25/D 178.6°, c = 2.5 in H2O(lit.)
Merck 
13,6388
BRN 
6260807
CAS DataBase Reference
51481-60-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-24/25-26-36/37/39-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N7758
Product name
Naloxone hydrochloride dihydrate
Purity
≥98% (TLC and titration), powder
Packaging
1g
Price
$599
Updated
2024/03/01
Sigma-Aldrich
Product number
N7758
Product name
Naloxone hydrochloride dihydrate
Purity
≥98% (TLC and titration), powder
Packaging
5g
Price
$760
Updated
2024/03/01
Sigma-Aldrich
Product number
N7758
Product name
Naloxone hydrochloride dihydrate
Purity
≥98% (TLC and titration), powder
Packaging
250mg
Price
$185
Updated
2024/03/01
Sigma-Aldrich
Product number
Y0000695
Product name
Naloxone for peak identification
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0000695
Price
$220
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR1802
Product name
Naloxone hydrochloride dihydrate
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
300mg
Price
$267
Updated
2024/03/01
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Naloxone hydrochloride dihydrate Chemical Properties,Usage,Production

Chemical Properties

White or almost white, hygroscopic, crystalline powder.

Uses

Naloxone Hydrochloride Dihydrate is a specific opioid antagonist. Narcotic antagonist.

Uses

Antagonist (to narcotics).

brand name

Narcan (Bristol-Myers Squibb); Narcan (Endo).

Biochem/physiol Actions

Competitive antagonist for μ, κ, δ, and σ opioid receptors; blocks the action of σ-agonists at opioid sites. Naloxone′s antagonistic effect last for about 45 min and thus, requires repeated dosage. It results in critical side effects such as pulmonary edema.

Purification Methods

This opiate antagonist has been recrystallised from EtOH/Et2O or H2O. It is soluble in H2O (5%) and EtOH but insoluble in Et2O. The free base has m 184o (177-178o also reported) after recrystallisation from EtOAc, and [] D -194.5o (c 0.93, CHCl3). [Olofson et al. Tetrahedron Lett 1567 1977, Gold et al. Med Res Rev 2 211 1982.]

Naloxone hydrochloride dihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Naloxone hydrochloride dihydrate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Naloxone hydrochloride dihydrate 51481-60-8
Price
US $0.00-0.00/g/Bag
Min. Order
1g
Purity
98%-102%
Supply Ability
1000G
Release date
2021-07-19
Career Henan Chemical Co
Product
Naloxone hydrochloride dihydrate 51481-60-8
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-98%
Supply Ability
100kg
Release date
2018-12-15

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