MONASTROL

Product Name: MONASTROL
CAS No.: 329689-23-8
Chemical Name: MONASTROL
Synonyms: CS-763;MONASTROL;(±)-Monastro;Monastrol, >=98%;MONASTROL (Free base);Ethyl 4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate;6-Methyl-4-(3-hydroxyphenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester;5-PyriMidinecarboxylic acid, 1,2,3,4-tetrahydro-4-(3-hydroxyphenyl)-6-Methyl-2-thioxo-, ethyl ester
CBNumber: CB92130960
Molecular Formula: C14H16N2O3S
Formula Weight: 292.35
MOL File: 329689-23-8.mol

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MONASTROL Property

Melting point:: 190-193℃ (ethanol )
Boiling point:: 441.3±55.0 °C(Predicted)
Density: 1.34±0.1 g/cm3 (20 ºC 760 Torr)
RTECS: UV6262400
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly, Heated)
form: White to light yellow solid.
pka: 9.63±0.10(Predicted)
color: White to Off-White
Sensitive: Light Sensitive

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Alfa Aesar

Product number: J67096
Product name: Monastrol, 98%
Packaging: 5mg
Price: $250
Updated: 2023/06/20

Cayman Chemical

Product number: 15044
Product name: Monastrol
Purity: ≥98%
Packaging: 1mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 15044
Product name: Monastrol
Purity: ≥98%
Packaging: 5mg
Price: $104
Updated: 2024/03/01

Cayman Chemical

Product number: 15044
Product name: Monastrol
Purity: ≥98%
Packaging: 10mg
Price: $135
Updated: 2024/03/01

Cayman Chemical

Product number: 15044
Product name: Monastrol
Purity: ≥98%
Packaging: 50mg
Price: $502
Updated: 2024/03/01

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MONASTROL Chemical Properties,Usage,Production

Uses

Monastrol is a small molecule that inhibits mitotic kinesin Eg5 and arrests cells in mitosis with monopolar spindles (1, 2).Monastrol is an anticancer agent against MCF-7 tumor cells (3).

Definition

ChEBI: A member of the class of thioureas that is 3,4-dihydropyrimidine-2(1)-thione substituted by a 3-hydroxyphenyl group at position 4, a methyl group at position 6 and a ethoxycarbonyl group at position 5.

Biological Activity

monastrol is a cell-permeable small molecule inhibitor of the mitotic kinesin, eg5. like other kinesins, eg5 can drive the movement of microtubules in vitro.

in vitro

previous study found that monastrol did not inhibit progression through s and g2 phases of the cell cycle or centrosome duplication. the mitotic arrest due to monastrol was also reversible rapidly. chromosomes in monastrol-treated cells frequently had both sister kinetochores attached to microtubules extending to the center of the monoaster. monastrol also inhibited bipolar spindle formation in xenopus egg extracts, however, monastrol did not prevent the targeting of eg5 to the monoastral spindles that form [1].

in vivo

previous study investigated the rat pk and tk of lasom 65, a monastrol derivative. results showed that lasom 65 had good bioavailability and linear pk after oral doses. lasom 65 distributed consistently in lung and fatty tissues. other investigated tissues presented smaller penetration ratios. adverse symptoms were observed only after iv administration, and regressed 3 h after dosing. no statistical differences were found for serum analysis, body weight and relative organ weight, indicating no acute toxicological effects. [2].

IC 50

14 μm

References

[1] kapoor tm,mayer tu,coughlin ml,mitchison tj. probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, eg5. j cell biol.2000 sep 4;150(5):975-88.
[2] torres bg,ucha fde t,pigatto mc,azeredo fj,haas se,dallegrave e,canto rf,eifler-lima vl,dalla costa t. pre-clinical pharmacokinetics and acute toxicological evaluation of a monastrol derivative anticancer candidate lasom 65 in rats. xenobiotica.2014 mar;44(3):254-63.

MONASTROL Preparation Products And Raw materials

Raw materials

Preparation Products

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MONASTROL Suppliers

China 108 India 1 United States 11 Global 120

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38632
Advantage: 58

ApexBio Technology

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Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

NE Scientific

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Country: United States
ProdList: 5030
Advantage: 55

Cayman Chemical Company

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Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

United States Biological

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Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

MedChemExpress

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Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

SynInnova Laboratories Inc.

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Email: sales@syninnova.com
Country: United States
ProdList: 491
Advantage: 50

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View Lastest Price from MONASTROL manufacturers

Career Henan Chemical Co

Product: Monastrol 329689-23-8
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1ton
Release date: 2020-01-10

329689-23-8, MONASTROLRelated Search:

DNA, SINGLE STRANDED, IMM. ON CELLULOSE, FROM CALF THYMUS*

(±)-Monastro

MONASTROL

Monastrol, >=98%

MONASTROL (Free base)

5-PyriMidinecarboxylic acid, 1,2,3,4-tetrahydro-4-(3-hydroxyphenyl)-6-Methyl-2-thioxo-, ethyl ester

6-Methyl-4-(3-hydroxyphenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester

CS-763

Ethyl 4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

329689-23-8