Nebivolol
- Product Name
- Nebivolol
- CAS No.
- 118457-14-0
- Chemical Name
- Nebivolol
- Synonyms
- R065824;Nobiten;Vasoxen;Nabilol;R-065824;R 065824;NEBIVOLOL;dl-Nebivolol;L-Nebivolo1 D4;Unii-030Y90569u
- CBNumber
- CB92131013
- Molecular Formula
- C22H25F2NO4
- Formula Weight
- 405.43
- MOL File
- 118457-14-0.mol
Nebivolol Property
- Melting point:
- 155-156°C
- Boiling point:
- 600.5±55.0 °C(Predicted)
- Density
- 1.309
- storage temp.
- -20°C Freezer
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated)
- pka
- pKa 8.22(H2O,t =25±1,Iundefined,Ar) (Uncertain)
- form
- Solid
- color
- White to Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 460622
- Product name
- Nebivolol
- Packaging
- 10mg
- Price
- $460
- Updated
- 2021/12/16
- Product number
- 460623
- Product name
- Nebivolol
- Packaging
- 500ug
- Price
- $566
- Updated
- 2021/12/16
- Product number
- API-1568
- Product name
- Nebivolol
- Purity
- 98%
- Packaging
- 1g
- Price
- $760
- Updated
- 2021/12/16
- Product number
- CD31004384
- Product name
- Nebivolol
- Purity
- 98+%
- Packaging
- 50mg
- Price
- $773
- Updated
- 2021/12/16
- Product number
- CD31004384
- Product name
- Nebivolol
- Purity
- 98+%
- Packaging
- 5mg
- Price
- $180
- Updated
- 2021/12/16
Nebivolol Chemical Properties,Usage,Production
Uses
Antihypertensive (β-blocker).
Uses
Nebivolol is a cardioselective beta-1 receptor blocking agent.
Definition
ChEBI: (R,S,S,S)-nebivolol is a 2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol] that has (1S,1'S,2R,2'S)-configuration. It is a conjugate base of a (R,S,S,S)-nebivolol(1+). It is an enantiomer of a (S,R,R,R)-nebivolol.
Clinical Use
Beta-adrenoceptor blocker:
Essential hypertension
Adjunct in heart failure
Drug interactions
Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Analgesics: NSAIDs antagonise hypotensive effect.
Anti-arrhythmics: increased risk of myocardial
depression and bradycardia; increased risk of
bradycardia, myocardial depression and AV block
with amiodarone; increased risk of myocardial
depression and bradycardia with flecainide.
Antidepressants: enhanced hypotensive effect with
MAOIs.
Antihypertensives; enhanced hypotensive effect;
increased risk of withdrawal hypertension with
clonidine; increased risk of first dose hypotensive effect
with post-synaptic alpha-blockers such as prazosin.
Antimalarials: increased risk of bradycardia with
mefloquine.
Antipsychotics enhanced hypotensive effect with
phenothiazines.
Calcium-channel blockers: increased risk of
bradycardia and AV block with diltiazem;
hypotension and heart failure possible with
nifedipine and nisoldipine; asystole, severe
hypotension and heart failure with verapamil.
Cytotoxics: possible increased risk of bradycardia
with crizotinib.
Diuretics: enhanced hypotensive effect.
Fingolimod: possibly increased risk of bradycardia.
Moxisylyte: possible severe postural hypotension.
Sympathomimetics: severe hypertension with
adrenaline and noradrenaline and possibly with
dobutamine.
Metabolism
Nebivolol is extensively metabolised in the liver by acyclic and aromatic hydroxylation, N-dealkylation, and glucuronidation. Hydroxylation is by cytochrome P450 isoenzyme CYP2D6, partly to active hydroxy-metabolites. It is excreted in the urine and faeces, almost entirely as metabolites.
Nebivolol Preparation Products And Raw materials
Raw materials
Preparation Products
Nebivolol Suppliers
- Tel
- 021-50790412
- Fax
- +86-21-50790419
- info@chemvon.com
- Country
- China
- ProdList
- 371
- Advantage
- 57
- Tel
- +86 (21) 5811-6473 5811-6475
- Fax
- +86 (21) 6129-4103
- sales@koutingchina.com
- Country
- China
- ProdList
- 496
- Advantage
- 60
- Tel
- 025-57798810
- Fax
- 025-57019371
- sales@sunlidabio.com
- Country
- China
- ProdList
- 3239
- Advantage
- 55
- Tel
- 025-58849295 18951903616;
- Fax
- 025-68650336
- info@adooq.cn
- Country
- China
- ProdList
- 2990
- Advantage
- 60
- Tel
- +86 (21) 61124340
- Fax
- +86 (21) 6129-4103
- Country
- China
- ProdList
- 9756
- Advantage
- 58
- Tel
- +86-21-5821 5861
- Fax
- +86-21-5106 2861
- sales@letopharm.com
- Country
- China
- ProdList
- 2384
- Advantage
- 58
- Tel
- 18086626237 18086626237
- Fax
- qq:2693528373
- sales@debyesci.com
- Country
- China
- ProdList
- 2645
- Advantage
- 56
- Tel
- 0575-18780151478 18582380095
- Fax
- 0575-89298961
- sales@artisbio.com
- Country
- China
- ProdList
- 2964
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 027-87466105 15377573527
- 2678564200@qq.com
- Country
- China
- ProdList
- 17987
- Advantage
- 58
- Tel
- 13382066392
- Country
- CHINA
- ProdList
- 4877
- Advantage
- 58
- Tel
- 15911056312
- liming@bio-fount.com
- Country
- China
- ProdList
- 9729
- Advantage
- 58
- Tel
- 0571-85361029
- Fax
- 0571-85361029
- synstar518@163.com
- Country
- China
- ProdList
- 1990
- Advantage
- 58
- Tel
- +8613373514458
- gantuo02@cngantuo.com
- Country
- China
- ProdList
- 203
- Advantage
- 58
- Tel
- +1-2135480471 +1-2135480471
- sales@sarms4muscle.com
- Country
- China
- ProdList
- 10473
- Advantage
- 58
- Tel
- 029-89275612 +8618991951683
- Fax
- 8618991951683
- mcbio_sales@163.com
- Country
- China
- ProdList
- 2251
- Advantage
- 58
- Tel
- +86-0551-65418684 +8618949823763
- Fax
- 0086-551-65418684
- sales@tnjchem.com
- Country
- China
- ProdList
- 25356
- Advantage
- 58
- Tel
- +8617013299288
- dj@sgtlifesciences.com
- Country
- China
- ProdList
- 12373
- Advantage
- 58
- Tel
- sales03@xazbbio.com
- Country
- CHINA
- ProdList
- 719
- Advantage
- 58
- Tel
- +8617735180244
- mike_yan@xuanranglobal.com
- Country
- CHINA
- ProdList
- 4017
- Advantage
- 58
- Tel
- +8618523575427
- sales@conier.com
- Country
- China
- ProdList
- 49374
- Advantage
- 58
- Tel
- +86-0371-86658258 +8613203830695
- Fax
- 0086-371-86658258
- factory@coreychem.com
- Country
- China
- ProdList
- 29811
- Advantage
- 58
- Tel
- 021-38015121 15000105423
- wulan@absin.cn
- Country
- China
- ProdList
- 24731
- Advantage
- 58
- Tel
- 88888888888
- hongquchem@qq.com
- Country
- China
- ProdList
- 5132
- Advantage
- 58
- Tel
- 010-60605840 15801484223;
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 29774
- Advantage
- 58
- Tel
- 18902340307 18902340307
- Fax
- 0751-2819901
- 3356812514@qq.com
- Country
- China
- ProdList
- 9245
- Advantage
- 58
- Tel
- 0755-66853366; 13670046396
- ORDERS@QCSRM.COM
- Country
- China
- ProdList
- 24326
- Advantage
- 58
- Tel
- 0751-2815987 13927875076
- Fax
- 0751-2828607
- 3007432263@qq.com
- Country
- China
- ProdList
- 9969
- Advantage
- 58
- Tel
- 13549236410
- sales@invivochem.cn
- Country
- China
- ProdList
- 6753
- Advantage
- 58
- Tel
- +86-027-59232304 15387063101
- 2881924050@qq.com
- Country
- China
- ProdList
- 9953
- Advantage
- 58
- Tel
- 13339985473
- C13339985473@163.com
- Country
- China
- ProdList
- 4921
- Advantage
- 58
- Tel
- 0576-85016990 15014006640
- 1002779550@qq.com
- Country
- China
- ProdList
- 161
- Advantage
- 58
- Tel
- 400-666-9280 18026564465
- 304903156@qq.com
- Country
- China
- ProdList
- 8001
- Advantage
- 58
- Tel
- 0751-2838688 13376594225
- 1276075424@qq.com
- Country
- China
- ProdList
- 9933
- Advantage
- 58
- Tel
- 021-67187366 19901745723
- info@bwtlab.com
- Country
- China
- ProdList
- 9268
- Advantage
- 58
- Tel
- 13393721940
- sales@vcommend.com
- Country
- China
- ProdList
- 9962
- Advantage
- 58
- Tel
- 17301488900
- Fax
- 025-85560043
- judy.xia@synzest.com
- Country
- China
- ProdList
- 12582
- Advantage
- 58
- Tel
- +86-18521732826
- market@aladdin-e.com
- Country
- China
- ProdList
- 48461
- Advantage
- 58
- Tel
- 18024082417
- market@ubiochem.com
- Country
- China
- ProdList
- 9272
- Advantage
- 58
- Tel
- +8615858145714
- Fax
- +86-571-56059825
- FandaChem@Gmail.com
- Country
- China
- ProdList
- 9206
- Advantage
- 55
- Tel
- +86-0512-83500002 +8615195660023
- sales@senfeida.com
- Country
- China
- ProdList
- 23046
- Advantage
- 58
- Tel
- +86-852-30606658
- market18@leapchem.com
- Country
- China
- ProdList
- 43340
- Advantage
- 58
- Tel
- 0592-5800732; +8613806035118
- Fax
- 0592-5854960
- xie@china-sinoway.com
- Country
- China
- ProdList
- 988
- Advantage
- 58
- Tel
- +86-17367732028 +86-17367732028
- kathy@hbyinsheng.com
- Country
- China
- ProdList
- 3512
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@zzsrm.com
- Country
- CHINA
- ProdList
- 6650
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@scientiapharm.com
- Country
- China
- ProdList
- 54
- Advantage
- 0
- Tel
- --
- Fax
- --
- sunchemsci@gmail.com
- Country
- China
- ProdList
- 3
- Advantage
- 50
View Lastest Price from Nebivolol manufacturers
- Product
- Nebivolol 118457-14-0
- Price
- US $200.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg/Month
- Release date
- 2022-11-23
- Product
- Nebivolol 118457-14-0
- Price
- US $100.00/g
- Min. Order
- 10g
- Purity
- 99%
- Supply Ability
- 1000g
- Release date
- 2023-03-10
- Product
- Nebivolol 118457-14-0
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- ≥95%
- Supply Ability
- 1kg
- Release date
- 2020-05-15