Nebivolol
- Product Name
- Nebivolol
- CAS No.
- 118457-14-0
- Chemical Name
- Nebivolol
- Synonyms
- R065824;Nobiten;Vasoxen;Nabilol;R-065824;R 065824;NEBIVOLOL;dl-Nebivolol;L-Nebivolo1 D4;Unii-030Y90569u
- CBNumber
- CB92131013
- Molecular Formula
- C22H25F2NO4
- Formula Weight
- 405.43
- MOL File
- 118457-14-0.mol
Nebivolol Property
- Melting point:
- 155-156°C
- Boiling point:
- 600.5±55.0 °C(Predicted)
- Density
- 1.309
- storage temp.
- -20°C Freezer
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated)
- pka
- pKa 8.22(H2O,t =25±1,Iundefined,Ar) (Uncertain)
- form
- Solid
- color
- White to Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 460622
- Product name
- Nebivolol
- Packaging
- 10mg
- Price
- $460
- Updated
- 2021/12/16
- Product number
- 460623
- Product name
- Nebivolol
- Packaging
- 500ug
- Price
- $566
- Updated
- 2021/12/16
- Product number
- API-1568
- Product name
- Nebivolol
- Purity
- 98%
- Packaging
- 1g
- Price
- $760
- Updated
- 2021/12/16
- Product number
- CD31004384
- Product name
- Nebivolol
- Purity
- 98+%
- Packaging
- 50mg
- Price
- $773
- Updated
- 2021/12/16
- Product number
- CD31004384
- Product name
- Nebivolol
- Purity
- 98+%
- Packaging
- 5mg
- Price
- $180
- Updated
- 2021/12/16
Nebivolol Chemical Properties,Usage,Production
Uses
Antihypertensive (β-blocker).
Uses
Nebivolol is a cardioselective beta-1 receptor blocking agent.
Definition
ChEBI: (R,S,S,S)-nebivolol is a 2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol] that has (1S,1'S,2R,2'S)-configuration. It is a conjugate base of a (R,S,S,S)-nebivolol(1+). It is an enantiomer of a (S,R,R,R)-nebivolol.
Clinical Use
Beta-adrenoceptor blocker:
Essential hypertension
Adjunct in heart failure
Drug interactions
Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Analgesics: NSAIDs antagonise hypotensive effect.
Anti-arrhythmics: increased risk of myocardial
depression and bradycardia; increased risk of
bradycardia, myocardial depression and AV block
with amiodarone; increased risk of myocardial
depression and bradycardia with flecainide.
Antidepressants: enhanced hypotensive effect with
MAOIs.
Antihypertensives; enhanced hypotensive effect;
increased risk of withdrawal hypertension with
clonidine; increased risk of first dose hypotensive effect
with post-synaptic alpha-blockers such as prazosin.
Antimalarials: increased risk of bradycardia with
mefloquine.
Antipsychotics enhanced hypotensive effect with
phenothiazines.
Calcium-channel blockers: increased risk of
bradycardia and AV block with diltiazem;
hypotension and heart failure possible with
nifedipine and nisoldipine; asystole, severe
hypotension and heart failure with verapamil.
Cytotoxics: possible increased risk of bradycardia
with crizotinib.
Diuretics: enhanced hypotensive effect.
Fingolimod: possibly increased risk of bradycardia.
Moxisylyte: possible severe postural hypotension.
Sympathomimetics: severe hypertension with
adrenaline and noradrenaline and possibly with
dobutamine.
Metabolism
Nebivolol is extensively metabolised in the liver by acyclic and aromatic hydroxylation, N-dealkylation, and glucuronidation. Hydroxylation is by cytochrome P450 isoenzyme CYP2D6, partly to active hydroxy-metabolites. It is excreted in the urine and faeces, almost entirely as metabolites.
Nebivolol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Nebivolol manufacturers
- Product
- Nebivolol 118457-14-0
- Price
- US $200.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg/Month
- Release date
- 2022-11-23
- Product
- Nebivolol 118457-14-0
- Price
- US $100.00/g
- Min. Order
- 10g
- Purity
- 99%
- Supply Ability
- 1000g
- Release date
- 2023-03-10
- Product
- Nebivolol 118457-14-0
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- ≥95%
- Supply Ability
- 1kg
- Release date
- 2020-05-15