ChemicalBook > CAS DataBase List > Nebivolol

Nebivolol

Product Name
Nebivolol
CAS No.
118457-14-0
Chemical Name
Nebivolol
Synonyms
R065824;Nobiten;Vasoxen;Nabilol;R-065824;R 065824;NEBIVOLOL;dl-Nebivolol;L-Nebivolo1 D4;Unii-030Y90569u
CBNumber
CB92131013
Molecular Formula
C22H25F2NO4
Formula Weight
405.43
MOL File
118457-14-0.mol
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Nebivolol Property

Melting point:
155-156°C
Boiling point:
600.5±55.0 °C(Predicted)
Density 
1.309
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly, Heated)
pka
pKa 8.22(H2O,t =25±1,Iundefined,Ar) (Uncertain)
form 
Solid
color 
White to Off-White
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Usbiological
Product number
460622
Product name
Nebivolol
Packaging
10mg
Price
$460
Updated
2021/12/16
Usbiological
Product number
460623
Product name
Nebivolol
Packaging
500ug
Price
$566
Updated
2021/12/16
Crysdot
Product number
CD31004384
Product name
Nebivolol
Purity
98+%
Packaging
5mg
Price
$180
Updated
2021/12/16
Crysdot
Product number
CD31004384
Product name
Nebivolol
Purity
98+%
Packaging
10mg
Price
$290
Updated
2021/12/16
AHH
Product number
API-1568
Product name
Nebivolol
Purity
98%
Packaging
1g
Price
$760
Updated
2021/12/16
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Nebivolol Chemical Properties,Usage,Production

Uses

Antihypertensive (β-blocker).

Uses

Nebivolol is a cardioselective beta-1 receptor blocking agent.

Definition

ChEBI: (R,S,S,S)-nebivolol is a 2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol] that has (1S,1'S,2R,2'S)-configuration. It is a conjugate base of a (R,S,S,S)-nebivolol(1+). It is an enantiomer of a (S,R,R,R)-nebivolol.

Clinical Use

Beta-adrenoceptor blocker:
Essential hypertension
Adjunct in heart failure

Drug interactions

Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Analgesics: NSAIDs antagonise hypotensive effect.
Anti-arrhythmics: increased risk of myocardial depression and bradycardia; increased risk of bradycardia, myocardial depression and AV block with amiodarone; increased risk of myocardial depression and bradycardia with flecainide.
Antidepressants: enhanced hypotensive effect with MAOIs.
Antihypertensives; enhanced hypotensive effect; increased risk of withdrawal hypertension with clonidine; increased risk of first dose hypotensive effect with post-synaptic alpha-blockers such as prazosin.
Antimalarials: increased risk of bradycardia with mefloquine.
Antipsychotics enhanced hypotensive effect with phenothiazines.
Calcium-channel blockers: increased risk of bradycardia and AV block with diltiazem; hypotension and heart failure possible with nifedipine and nisoldipine; asystole, severe hypotension and heart failure with verapamil.
Cytotoxics: possible increased risk of bradycardia with crizotinib.
Diuretics: enhanced hypotensive effect.
Fingolimod: possibly increased risk of bradycardia. Moxisylyte: possible severe postural hypotension.
Sympathomimetics: severe hypertension with adrenaline and noradrenaline and possibly with dobutamine.

Metabolism

Nebivolol is extensively metabolised in the liver by acyclic and aromatic hydroxylation, N-dealkylation, and glucuronidation. Hydroxylation is by cytochrome P450 isoenzyme CYP2D6, partly to active hydroxy-metabolites. It is excreted in the urine and faeces, almost entirely as metabolites.

Nebivolol Preparation Products And Raw materials

Raw materials

Preparation Products

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Nebivolol Suppliers

China 47 France 1 India 4 United States 9 Global 61
Clearsynth Labs Limited
Tel
+91-22-26355700
Fax
+91-22-26355701
Email
info@clearsynth.com
Country
India
ProdList
9679
Advantage
58
Pharmaffiliates Analytics and Synthetics P. Ltd
Tel
--
Fax
--
Email
mktg@pharmaffiliates.com
Country
India
ProdList
6739
Advantage
58
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View Lastest Price from Nebivolol manufacturers

Hebei Mingeng Biotechnology Co., Ltd
Product
Nebivolol 118457-14-0
Price
US $200.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg/Month
Release date
2022-11-23
Shijiazhuang Gantuo Biotechnology Co., Ltd
Product
Nebivolol 118457-14-0
Price
US $100.00/g
Min. Order
10g
Purity
99%
Supply Ability
1000g
Release date
2023-03-10
BOC Sciences
Product
Nebivolol 118457-14-0
Price
US $0.00/g
Min. Order
1g
Purity
≥95%
Supply Ability
1kg
Release date
2020-05-15

118457-14-0, NebivololRelated Search:

(+)-Nebivolol Nebivolol Nebivolol 3-(4-FLUOROPHENOXY)PROPAN-1-AMINE HYDROCHLORIDE

  • NEBIVOLOL
  • Unii-030Y90569u
  • (1S)-1-[(2R)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-[[(2S)-2-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyethyl]amino]ethanol
  • dl-Nebivolol
  • [2R*[R*[R*(S*)]]]-alpha,alpha'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol
  • NEBILET; BYSTOLIC; R 065824; R065824; R-065824
  • R 065824
  • R065824
  • R-065824
  • Nebivolol, racemic mixture
  • 2H-1-Benzopyran-2-methanol, α,α'-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-, (αR,α'R,2R,2'S)-rel-
  • Nebivolol USP/EP/BP
  • Nebivolol (R 065824)
  • Nebivolol D4Q: What is Nebivolol D4 Q: What is the CAS Number of Nebivolol D4 Q: What is the storage condition of Nebivolol D4 Q: What are the applications of Nebivolol D4
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  • Benzaldehyde,3-bromo-2-fluoro-9-(trifluoromethyl)-
  • L-Nebivolo1 D4
  • Nebivolol-d4-O-D-Glucuronide (Mixture of Diastereomers)
  • Nabilol
  • Nebivolol Impurity 111
  • 118457-14-0
  • Nebivolol
  • Pharmaceuticals