M-HYDROXY BENZYL CYANIDE

Product Name: M-HYDROXY BENZYL CYANIDE
CAS No.: 25263-44-9
Chemical Name: M-HYDROXY BENZYL CYANIDE
Synonyms: M-HYDROXY BENZYL CYANIDE;3-hydroxyphenyacetonitrile;M-HYDROXYPHENYLACETONITRILE;3-HYDROXYPHENYLACETONITRILE;3-Hydroxy-Benzeneacetonitrile;Benzeneacetonitrile, 3-hydroxy-;2-(3-hydroxyphenyl)acetonitrile;M-HYDROXY BENZYL CYANIDE(3-HYDROXYPHENYL)-ACETONITRILE
CBNumber: CB9215397
Molecular Formula: C8H7NO
Formula Weight: 133.15
MOL File: 25263-44-9.mol

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M-HYDROXY BENZYL CYANIDE Property

Melting point:: 53 °C
Boiling point:: 305.5±17.0 °C(Predicted)
Density: 1.167±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: powder to crystal
pka: 9.51±0.10(Predicted)
color: White to Orange to Green

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Safety

HS Code: 2926.90.5050

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: H1615
Product name: (3-Hydroxyphenyl)acetonitrile
Purity: >95.0%(GC)
Packaging: 1g
Price: $111
Updated: 2025/07/31

TCI Chemical

Product number: H1615
Product name: (3-Hydroxyphenyl)acetonitrile
Purity: >95.0%(GC)
Packaging: 5g
Price: $369
Updated: 2025/07/31

TRC

Product number: H100570
Product name: 2-(3-Hydroxyphenyl)acetonitrile
Packaging: 500mg
Price: $85
Updated: 2021/12/16

Ambeed

Product number: A129135
Product name: 2-(3-Hydroxyphenyl)acetonitrile
Purity: 95%
Packaging: 1g
Price: $106
Updated: 2021/12/16

Ambeed

Product number: A129135
Product name: 2-(3-Hydroxyphenyl)acetonitrile
Purity: 95%
Packaging: 100mg
Price: $68
Updated: 2021/12/16

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M-HYDROXY BENZYL CYANIDE Chemical Properties,Usage,Production

Uses

2-(3-Hydroxyphenyl)acetonitrile is used in preparation of Pyrrolidine Sulfonamide compounds as TRPV4 antagonists.

Synthesis

19924-43-7

25263-44-9

Step 1: Dissolve 2-(3-methoxyphenyl)acetonitrile (2 g, 13.59 mmol) in 13 mL of anhydrous dichloromethane under nitrogen protection and cool to 0°C. A 1 M solution of boron tribromide in dichloromethane (28.54 mL, 28.54 mmol) was slowly added dropwise. After the dropwise addition was completed, the reaction mixture was stirred at room temperature for 20 hours. After completion of the reaction, the mixture was poured into ice water and extracted three times with dichloromethane. The organic phases were combined, washed with brine and dried over anhydrous sodium sulfate. After concentration under reduced pressure, the crude product was purified by silica gel column chromatography using petroleum ether/ethyl acetate (80/20) as eluent to give 1.28 g (71% yield) of 2-(3-hydroxyphenyl)acetonitrile.

References

[1] Patent: US2006/142553, 2006, A1. Location in patent: Page/Page column 11 - 12
[2] Patent: WO2008/46598, 2008, A1. Location in patent: Page/Page column 57
[3] Patent: WO2013/651, 2013, A1. Location in patent: Page/Page column 35; 55
[4] Patent: US2014/88074, 2014, A1. Location in patent: Paragraph 0286; 0287; 0524; 0525
[5] Patent: US6180627, 2001, B2

M-HYDROXY BENZYL CYANIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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M-HYDROXY BENZYL CYANIDE Suppliers

Americas 1 China 43 Europe 1 India 6 Japan 1 United Kingdom 5 United States 9 Global 66

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
Advantage: 58

TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
Fax: 03-3668-0520
Email: Sales-JP@TCIchemicals.com
Country: Japan
ProdList: 28387
Advantage: 80

TCI Europe

Tel: 320-37350700
Fax: +32 (0)37350701
Email: sales@tcieurope.eu
Country: Europe
ProdList: 23671
Advantage: 75

TCI AMERICA

Tel: 800-4238616
Fax: +1-888-520-1075 / +1-503-283-1987
Email: sales@tciamerica.com
Country: Americas
ProdList: 23653
Advantage: 75

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18333
Advantage: 56

Yancheng KangdiSen Pharmaceutical Co., Ltd.

Tel: 13812573443
Fax: -
Email: tongbenwan22@163.com
Country: China
ProdList: 1980
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai Witofly Chemical Co. ,Ltd.

Tel: 021-50630626 18964684208
Email: sales@witofly.com
Country: China
ProdList: 1606
Advantage: 55

Dalian lichuang Chemical Co., Ltd

Tel: 0411-0411-00000000 13644282108
Fax: -
Email: 3500508746@qq.com
Country: China
ProdList: 2896
Advantage: 55

25263-44-9, M-HYDROXY BENZYL CYANIDERelated Search:

2-Bromo-4,5-dimethoxyphenylacetonitrile (3-Methoxyphenyl)acetonitrile (3,4-Dimethoxyphenyl)acetonitrile 3-PHENOXYPHENYLACETONITRILE Fenvalerate (+/-)-Verapamil hydrochloride 3,5-DIMETHOXYPHENYLACETONITRILE 3,4-(Methylenedioxy)phenylacetonitrile (4,5-DIMETHOXY-2-NITRO-PHENYL)-ACETONITRILE 2,5-DIMETHOXYPHENYLACETONITRILE 4-BENZYLOXY-3-METHOXYPHENYLACETONITRILE 3-BENZYLOXYBENZYL ALCOHOL 3,4,5-Trimethoxyphenylacetonitrile 4-HYDROXY-3-METHOXYPHENYLACETONITRILE 3-PHENOXYBENZALDEHYDE CYANOHYDRIN, 70 WT% SOLUTION IN ETHER 55) PARA HYDROXY BENZYL CYANIDE 3-ETHOXYPHENYLACETONITRILE 4-ETHOXY-3-METHOXYPHENYLACETONITRILE

3-HYDROXYPHENYLACETONITRILE

M-HYDROXYPHENYLACETONITRILE

M-HYDROXY BENZYL CYANIDE

M-HYDROXY BENZYL CYANIDE(3-HYDROXYPHENYL)-ACETONITRILE

2-(3-hydroxyphenyl)acetonitrile

3-Hydroxy-Benzeneacetonitrile

Benzeneacetonitrile, 3-hydroxy-

3-hydroxyphenyacetonitrile

25263-44-9

Aromatic Nitriles