3-(4-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
- Product Name
- 3-(4-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
- CAS No.
- 2881-63-2
- Chemical Name
- 3-(4-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
- Synonyms
- NSC 406743;ETHYL (4-CHLOROBENZOYL)ACETATE;Ethyl (4-chlorobenzoyl)acetate, >=97%;Ethyl 4-chloro-β-oxobenzenepropanoate;2-[(4-chlorophenyl)-oxomethyl]butanoate;Ethyl 3-Oxo-3-(4-chlorophenyl)propionate;ETHYL 3-(4-CHLOROPHENYL)-3-OXOPROPANOATE;Ethyl 3-(4-chlorophenyl)-3-oxo-propionate;Benzenepropanoicacid,4-chloro-β-oxo-,ethylester;3-(4-Chlorophenyl)-3-oxopropanoic acid ethyl ester
- CBNumber
- CB9217447
- Molecular Formula
- C11H11ClO3
- Formula Weight
- 226.66
- MOL File
- 2881-63-2.mol
3-(4-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER Property
- Melting point:
- 38 °C(Solv: ethanol (64-17-5))
- Boiling point:
- 268-269 °C(lit.)
- Density
- 1.218 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.5500(lit.)
- Flash point:
- >230 °F
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Acetone
- form
- powder to lump
- pka
- 9.56±0.25(Predicted)
- color
- White to Orange to Green
- InChI
- InChI=1S/C11H11ClO3/c1-2-15-11(14)7-10(13)8-3-5-9(12)6-4-8/h3-6H,2,7H2,1H3
- InChIKey
- DGCZHKABHPDNCC-UHFFFAOYSA-N
- SMILES
- C1(C=CC(Cl)=CC=1)C(=O)CC(=O)OCC
- CAS DataBase Reference
- 2881-63-2(CAS DataBase Reference)
Safety
- WGK Germany
- 3
- HS Code
- 2918300090
- Storage Class
- 11 - Combustible Solids
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 559210
- Product name
- Ethyl (4-chlorobenzoyl)acetate
- Packaging
- 1g
- Price
- $58
- Updated
- 2025/07/31
- Product number
- 559210
- Product name
- Ethyl (4-chlorobenzoyl)acetate
- Packaging
- 5g
- Price
- $105.5
- Updated
- 2025/07/31
- Product number
- E1059
- Product name
- Ethyl 3-Oxo-3-(4-chlorophenyl)propionate
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $84
- Updated
- 2025/07/31
- Product number
- E1059
- Product name
- Ethyl 3-Oxo-3-(4-chlorophenyl)propionate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $249
- Updated
- 2025/07/31
- Product number
- B124820
- Product name
- Ethyl3-(4-Chlorophenyl)-3-oxopropanoate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
3-(4-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER Chemical Properties,Usage,Production
Uses
Ethyl (4-chlorobenzoyl)acetate may be used to synthesize 2-(carboethoxy)-3-(4′-chloro)phenylquinoxaline 1,4-dioxide.
Synthesis
3-(4-Chloro-phenyl)-3-oxo-propionic acid ethyl ester can be prepared from 4-chlorobenzoic acid.
To a solution of 4-chlorobenzoic acid (30.0 g, 0.192 mol) in DCM (250 mL) was added oxalyl chloride (25 mL, 0.288 mol) and then DMF (0.5 mL) was added dropwise. The reaction mixture was refluxed for 2 hours. The clarified yellow solution obtained was concentrated under vacuum to obtain the acyl chloride as a yellow liquid. TEA (67 mL) was added to a solution of potassium ethyl malonate (41 g, 0.241 mol) in acetonitrile (537 mL). After cooling in an ice-salt bath, MgCl2 (27.4 g, 0.288 mol) was added and the resulting mixture was stirred at this temperature for 3 hours. Acyl chloride (prepared as described above) was added and the reaction mixture was warmed to ambient temperature and stirred overnight. The mixture was cooled in an ice bath and 2N HCl (600 mL) was carefully added. The mixture was stirred in an ice bath for 1.5 hours and then transferred to a split funnel and extracted with ethyl acetate (3 x 200 mL). The combined organic layers were washed with saturated sodium bicarbonate (450 mL), brine (250 mL), dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo to afford the crude product ethyl 3-(4-chlorophenyl)-3-oxo-propionate (48.6 g), which was used without purification.
3-(4-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-(4-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER manufacturers
- Product
- ethyl 3-(4-chlorophenyl)-3-oxopropanoate 2881-63-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99.2%
- Supply Ability
- 100 tons
- Release date
- 2022-01-17
- Product
- 3-(4-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER 2881-63-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 150KG
- Release date
- 2019-07-09