QUINAZOLINE, 2,4-DICHLORO-6-NITRO

Product Name: QUINAZOLINE, 2,4-DICHLORO-6-NITRO
CAS No.: 74173-77-6
Chemical Name: QUINAZOLINE, 2,4-DICHLORO-6-NITRO
Synonyms: 2,4-Dichloro-6-Nitro Quinazoline;QUINAZOLINE, 2,4-DICHLORO-6-NITRO
CBNumber: CB9217942
Molecular Formula: C8H3Cl2N3O2
Formula Weight: 244.03
MOL File: 74173-77-6.mol

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QUINAZOLINE, 2,4-DICHLORO-6-NITRO Property

Boiling point:: 366℃
Density: 1.674
Flash point:: 175℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -1.81±0.30(Predicted)
Appearance: Light yellow to gray Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FD143610
Product name: 2,4-Dichloro-6-nitroquinazoline
Packaging: 100mg
Price: $79
Updated: 2021/12/16

Matrix Scientific

Product number: 099092
Product name: 2,4-Dichloro-6-nitroquinazoline
Purity: 95+%
Packaging: 250mg
Price: $435
Updated: 2021/12/16

AK Scientific

Product number: Z5090
Product name: 2,4-Dichloro-6-nitroquinazoline
Packaging: 1g
Price: $465
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0324492
Product name: 2,4-DICHLORO-6-NITRO QUINAZOLINE
Purity: 95.00%
Packaging: 5MG
Price: $499.92
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 35796
Product name: 2,4-Dichloro-6-nitroquinazoline
Purity: 95+%
Packaging: 250mg
Price: $532
Updated: 2021/12/16

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QUINAZOLINE, 2,4-DICHLORO-6-NITRO Chemical Properties,Usage,Production

Synthesis

32618-85-2

74173-77-6

General procedure for the synthesis of 2,4-dichloro-6-nitroquinazoline from 2,4-dihydroxy-6-nitroquinazoline: To a solution of 6-nitroquinazoline-2,4(1H,3H)-dione (34 g, 164.14 mmol) in trichlorophosphorus (POCl3, 150 mL) was added N,N-dimethylaniline (60 g, 492.42 mmol). The reaction mixture was stirred at 110 °C for 5 hours. After completion of the reaction, the mixture was concentrated under reduced pressure and the remaining residue was neutralized with aqueous sodium bicarbonate. The aqueous phase was extracted with ethyl acetate (EtOAc, 80 mL x 3). The organic phases were combined, concentrated to dryness and the residue was purified by silica gel column chromatography (eluent: dichloromethane/petroleum ether = 2:1) to afford 2,4-dichloro-6-nitroquinazoline (5 g, yield: 13%) as a yellow solid.

References

[1] Patent: US2010/204226, 2010, A1. Location in patent: Page/Page column 61
[2] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 9, p. 2797 - 2807
[3] Patent: CN102250075, 2016, B. Location in patent: Paragraph 0395; 0414; 0415
[4] Patent: WO2018/114700, 2018, A1. Location in patent: Page/Page column 22; 53
[5] Patent: WO2015/200534, A2. Location in patent: Paragraph 00414

QUINAZOLINE, 2,4-DICHLORO-6-NITRO Preparation Products And Raw materials

Raw materials

Preparation Products

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QUINAZOLINE, 2,4-DICHLORO-6-NITRO Suppliers

China 69 India 1 United Kingdom 3 United States 9 Global 82

PharmaBlock Sciences (Nanjing),Inc.

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View Lastest Price from QUINAZOLINE, 2,4-DICHLORO-6-NITRO manufacturers

Career Henan Chemical Co

Product: 2,4-Dichloro-6-nitroquinazoline 74173-77-6
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-07-09

Career Henan Chemical Co

Product: 2,4-Dichloro-6-nitroquinazoline 74173-77-6
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-07-09

74173-77-6, QUINAZOLINE, 2,4-DICHLORO-6-NITRORelated Search:

4-CHLOROQUINAZOLIN-6-AMINE QUINAZOLINE, 2,4-DICHLORO-6-NITRO 2,4-Dichloroquinazoline 4-CHLORO-6-NITROQUINAZOLINE

2,4-Dichloro-6-Nitro Quinazoline

QUINAZOLINE, 2,4-DICHLORO-6-NITRO

74173-77-6