ChemicalBook > CAS DataBase List > QUINAZOLINE, 2,4-DICHLORO-6-NITRO

QUINAZOLINE, 2,4-DICHLORO-6-NITRO

Product Name
QUINAZOLINE, 2,4-DICHLORO-6-NITRO
CAS No.
74173-77-6
Chemical Name
QUINAZOLINE, 2,4-DICHLORO-6-NITRO
Synonyms
2,4-Dichloro-6-Nitro Quinazoline;QUINAZOLINE, 2,4-DICHLORO-6-NITRO
CBNumber
CB9217942
Molecular Formula
C8H3Cl2N3O2
Formula Weight
244.03
MOL File
74173-77-6.mol
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QUINAZOLINE, 2,4-DICHLORO-6-NITRO Property

Boiling point:
366℃
Density 
1.674
Flash point:
175℃
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-1.81±0.30(Predicted)
Appearance
Light yellow to gray Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FD143610
Product name
2,4-Dichloro-6-nitroquinazoline
Packaging
100mg
Price
$79
Updated
2021/12/16
Matrix Scientific
Product number
099092
Product name
2,4-Dichloro-6-nitroquinazoline
Purity
95+%
Packaging
250mg
Price
$435
Updated
2021/12/16
AK Scientific
Product number
Z5090
Product name
2,4-Dichloro-6-nitroquinazoline
Packaging
1g
Price
$465
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0324492
Product name
2,4-DICHLORO-6-NITRO QUINAZOLINE
Purity
95.00%
Packaging
5MG
Price
$499.92
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
35796
Product name
2,4-Dichloro-6-nitroquinazoline
Purity
95+%
Packaging
250mg
Price
$532
Updated
2021/12/16
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QUINAZOLINE, 2,4-DICHLORO-6-NITRO Chemical Properties,Usage,Production

Synthesis

32618-85-2

74173-77-6

General procedure for the synthesis of 2,4-dichloro-6-nitroquinazoline from 2,4-dihydroxy-6-nitroquinazoline: To a solution of 6-nitroquinazoline-2,4(1H,3H)-dione (34 g, 164.14 mmol) in trichlorophosphorus (POCl3, 150 mL) was added N,N-dimethylaniline (60 g, 492.42 mmol). The reaction mixture was stirred at 110 °C for 5 hours. After completion of the reaction, the mixture was concentrated under reduced pressure and the remaining residue was neutralized with aqueous sodium bicarbonate. The aqueous phase was extracted with ethyl acetate (EtOAc, 80 mL x 3). The organic phases were combined, concentrated to dryness and the residue was purified by silica gel column chromatography (eluent: dichloromethane/petroleum ether = 2:1) to afford 2,4-dichloro-6-nitroquinazoline (5 g, yield: 13%) as a yellow solid.

References

[1] Patent: US2010/204226, 2010, A1. Location in patent: Page/Page column 61
[2] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 9, p. 2797 - 2807
[3] Patent: CN102250075, 2016, B. Location in patent: Paragraph 0395; 0414; 0415
[4] Patent: WO2018/114700, 2018, A1. Location in patent: Page/Page column 22; 53
[5] Patent: WO2015/200534, A2. Location in patent: Paragraph 00414

QUINAZOLINE, 2,4-DICHLORO-6-NITRO Preparation Products And Raw materials

Raw materials

Preparation Products

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QUINAZOLINE, 2,4-DICHLORO-6-NITRO Suppliers

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View Lastest Price from QUINAZOLINE, 2,4-DICHLORO-6-NITRO manufacturers

Career Henan Chemical Co
Product
2,4-Dichloro-6-nitroquinazoline 74173-77-6
Price
US $8.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
100kg
Release date
2019-07-09
Career Henan Chemical Co
Product
2,4-Dichloro-6-nitroquinazoline 74173-77-6
Price
US $8.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
100kg
Release date
2019-07-09

74173-77-6, QUINAZOLINE, 2,4-DICHLORO-6-NITRORelated Search:

4-CHLOROQUINAZOLIN-6-AMINE QUINAZOLINE, 2,4-DICHLORO-6-NITRO 2,4-Dichloroquinazoline 4-CHLORO-6-NITROQUINAZOLINE

  • 2,4-Dichloro-6-Nitro Quinazoline
  • QUINAZOLINE, 2,4-DICHLORO-6-NITRO
  • 74173-77-6