Hygromycin B

Product Name: Hygromycin B
CAS No.: 31282-04-9
Chemical Name: Hygromycin B
Synonyms: HYGROMYCIN B HYDRATE;950U/MG;Hygromix;Hygrovetin;hygromix-8;hygrovetine;hygromix2.4;hydromycinb;antihelmycin;Hygromycin B
CBNumber: CB9219683
Molecular Formula: C20H37N3O13
Formula Weight: 527.52
MOL File: 31282-04-9.mol

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Hygromycin B Property

Melting point:: 160-180°C
alpha: D20 +20.2° (c = 1 in water)
Boiling point:: 608.13°C (rough estimate)
Density: 1.4252 (rough estimate)
refractive index: 1.6300 (estimate)
storage temp.: 2-8°C
solubility: H₂O: 50 mg/mL As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 30 days.
form: powder
pka: 7.1, 8.8(at 25℃)
color: faintly brown to brown
PH: pH (25g/l, 25℃ ) : 9.5～12.5
Water Solubility: Miscible with water, methanol, buffer solution and ethanol. Immiscible with less polar solvents.
Merck: 14,4852
BRN: 6755837
Stability:: Hygroscopic
EPA Substance Registry System: Hygromycin B (31282-04-9)

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Safety

Hazard Codes: T+,Xn,T
Risk Statements: 26/27/28-41-42/43-40-36-23/24/25
Safety Statements: 23-26-28-36/37/39-45-22-36-36/37
RIDADR: UN 3462 6.1/PG 1
WGK Germany: 3
RTECS: WK2130000
F: 19
HazardClass: 6.1
PackingGroup: I
HS Code: 29419059
Toxicity: mmo-esc 250 mg/L AACHAX 18,798,80

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P284Wear respiratory protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 10843555001
Product name: Hygromycin B
Purity: from Streptomyces hygroscopicus
Packaging: 20ml
Price: $312
Updated: 2024/03/01

Sigma-Aldrich

Product number: 400050
Product name: Hygromycin B, Streptomyces sp., Cell Culture-Tested - CAS 31282-04-9 - Calbiochem
Purity: Unique aminoglycoside antibiotic that inhibits the growth of prokaryotic (bacteria) and eukaryotic microorganisms (yeasts) and mammalian cells.
Packaging: 1G
Price: $348
Updated: 2022/05/15

Sigma-Aldrich

Product number: 400050
Product name: Hygromycin B, Streptomyces sp., Cell Culture-Tested - CAS 31282-04-9 - Calbiochem
Purity: Unique aminoglycoside antibiotic that inhibits the growth of prokaryotic (bacteria) and eukaryotic microorganisms (yeasts) and mammalian cells.
Packaging: 5G
Price: $1290
Updated: 2022/05/15

TCI Chemical

Product number: H1509
Product name: Hygromycin B
Purity: >80.0%(HPLC)
Packaging: 200mg
Price: $52
Updated: 2024/03/01

TCI Chemical

Product number: H1509
Product name: Hygromycin B
Purity: >80.0%(HPLC)
Packaging: 1g
Price: $176
Updated: 2024/03/01

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Hygromycin B Chemical Properties,Usage,Production

Description

Hygromycin B is an aminoglycoside antibiotic that has been found in S. hygroscopicus. It is active against E. coli (MIC = 150 μg/ml) and cytotoxic to both prokaryotic and eukaryotic cells via inhibition of protein synthesis. Hygromycin B has commonly been used in molecular and cell biology applications to select for transformed cells expressing the E. coli hygromycin resistance genes hyg or hph.

Chemical Properties

White to off-white lyophilized powder

Uses

antibacterial, anthelmintic; LD50 ip (rat) 63mg/Kg

Uses

Hygromycin B, a selective antibiotic that is effective on most bacteria, fungi and higher eukaryotes, inhibits protein synthesis by interfering with translocation and causing mistranslation at the 70S ribosome

Uses

Hygromycin B is an aminoglycoside and a selective antibiotic agent for the hph gene. Hygromycin B inhibits protein synthesis by interfering with translocation and causing mistranslation at the 70S rib osome

Uses

Hygromycin B is a trisaccharide aminoglycoside with a terminal cyclitol produced by Streptomyces hygroscopicus, reported by researchers at Eli Lily in the early 1950s. Hygromycin B belongs to the destomycin family of aminoglycosides which contain a unique cyclic structure linking the terminal saccharide. Hygromycin B exhibits broad spectrum antibiotic and anthelmintic activity, and is used as a feed additive for swine and poultry. Hygromycin B inhibits polypeptide synthesis by binding peptidyl-tRNA and preventing translocation by Elongation Factor 2.

Application

Hygromycin B was found in the culture broth of Streptomyces hygroscopicus by Lilly Research Laboratories in 1953, as a mixture with hygromycin A. It showed activity against a variety of gram-positive and gram-negative bacteria as well as fungi. Hygromycin B has been used for therapy of helminthic infections in swine and poultry.

General Description

Amorphous solid or tan powder.

Air & Water Reactions

Water soluble.

Reactivity Profile

Weakly basic.

Fire Hazard

Flash point data for Hygromycin B are not available; however Hygromycin B is probably combustible.

Biochem/physiol Actions

Mode of Action: The product acts by inhibiting protein synthesis by inducing the misreading of the m-RNA template in the prokaryote, with the potency to inhibit translation. Antimicrobial Spectrum: Hygromycin B acts against bacteria, fungi and higher eukaryotic cells.

Safety Profile

Poison by intraperitoneal route. Mutation data reported. When heated to decomposition it emits toxic fumes of Nox

storage

+4°C

References

[1] brodersen de, clemons wm jr, carter ap, et al. the structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin b on the 30s ribosomal subunit. cell, 2000, 103 (7): 1143-1154.
[2] ganoza mc, kiel mc. a ribosomal atpase is a target for hygromycin b inhibition on escherichia coli ribosomes. antimicrob agents chemother, 2001, 45 (10): 2813-2819.

Hygromycin B Preparation Products And Raw materials

Raw materials

Preparation Products

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Hygromycin B Suppliers

Americas 1 Australia 1 Canada 4 China 256 Europe 4 France 1 Germany 11 India 12 Japan 4 Poland 1 South Korea 1 Switzerland 3 The Netherlands 1 United Kingdom 16 United States 46 Global 362

Nanjing Sunlida Biological Technology Co., Ltd.

Tel: 025-57798810
Fax: 025-57019371
Email: sales@sunlidabio.com
Country: China
ProdList: 3750
Advantage: 55

Taizhou Chemedir Biopharm-tech. Co., Ltd

Tel: 0523-86200218 18994667082
Fax: +86 523-86200613
Email: sale1_cmd@chemedir.com
Country: China
ProdList: 110
Advantage: 64

Shanghai Linka Biotechnology Co., Ltd.

Tel: 15901858719
Fax: qq2126935757
Email: 2126935757@qq.com
Country: China
ProdList: 311
Advantage: 55

Hubei widely chemical technology Co., Ltd.

Tel: 027-59402396 13419635609
Fax: 027-83989310
Email: 13419635609@163.com
Country: China
ProdList: 1993
Advantage: 55

Hu' nan Yunbang Pharmaceutical Co., Ltd.

Tel: 0731-85561020 15386497078
Email: yunbang@yunbangapi.com
Country: China
ProdList: 4200
Advantage: 58

Hunan Wokai Biotechnology Co., Ltd.

Tel: 0744-2221508 13126795102
Fax: 0744-6652010
Email: 2577930172@qq.com
Country: China
ProdList: 319
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24539
Advantage: 81

BeiJing Hwrk Chemicals Limted

Tel: 0757-86329057 18501085097
Fax: 010-89508210
Email: sales3.gd@hwrkchemical.com
Country: China
ProdList: 7583
Advantage: 55

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View Lastest Price from Hygromycin B manufacturers

Shanghai Affida new material science and technology center

Product: Hygromycin B 31282-04-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99
Supply Ability: 50000KG/month
Release date: 2024-04-24

Henan Fengda Chemical Co., Ltd

Product: Hygromycin B 31282-04-9
Price: US $8.00-0.80/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-09

Wuhan Xinhao Biotechnology Co., Ltd

Product: hygromycin B solution from streptomyces hygroscopicus 31282-04-9
Price: US $10.00-100.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000 Metric Ton/Month
Release date: 2024-03-19

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