3-NITRO-6-PYRIDINECARBOXALDEHYDE
- Product Name
- 3-NITRO-6-PYRIDINECARBOXALDEHYDE
- CAS No.
- 35969-75-6
- Chemical Name
- 3-NITRO-6-PYRIDINECARBOXALDEHYDE
- Synonyms
- 5-Nitropicolinaldehyde;5-Nitro-2-forMylpyridine;5-nitropyridine-2-carbaldehyde;5-Nitro-2-pyridinecarbaldehyde;5-Nitropyridine-2-carboxaldehyde;5-NITRO-2-PYRIDINECARBOXALDEHYDE;3-NITRO-6-PYRIDINECARBOXALDEHYDE;2-Pyridinecarboxaldehyde, 5-nitro-
- CBNumber
- CB9221569
- Molecular Formula
- C6H4N2O3
- Formula Weight
- 152.11
- MOL File
- 35969-75-6.mol
3-NITRO-6-PYRIDINECARBOXALDEHYDE Property
- Melting point:
- 54-57℃
- Boiling point:
- 298.7±25.0 °C(Predicted)
- Density
- 1.432±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -0.31±0.10(Predicted)
- Appearance
- Brown to reddish brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- N519905
- Product name
- 5-Nitropyridine-2-carbaldehyde
- Packaging
- 5g
- Price
- $1175
- Updated
- 2021/12/16
- Product number
- 4H54-1-FP
- Product name
- 5-Nitropyridine-2-carbaldehyde
- Purity
- 97.0%
- Packaging
- 5G
- Price
- $890
- Updated
- 2021/12/16
- Product number
- OR921887
- Product name
- 3-Nitro-6-pyridinecarboxaldehyde
- Purity
- 95%
- Packaging
- 5g
- Price
- $580
- Updated
- 2021/12/16
- Product number
- CS-W005150
- Product name
- 5-Nitropicolinaldehyde
- Purity
- >97.0%
- Packaging
- 250mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 4H54-1-FP
- Product name
- 5-Nitropyridine-2-carbaldehyde
- Purity
- 97.0%
- Packaging
- 250mg
- Price
- $128
- Updated
- 2021/12/16
3-NITRO-6-PYRIDINECARBOXALDEHYDE Chemical Properties,Usage,Production
Uses
5-Nitropyridine-2-carbaldehyde is used in the synthetic preparation of pyridine-2-carboxaldehyde thiosemicarbazone which has antitumor activity.
Synthesis
21203-68-9
35969-75-6
The general procedure for the synthesis of 5-nitropyridine-2-carbaldehyde using 2-methyl-5-nitropyridine as starting material was as follows: 2-methyl-5-nitropyridine (3.0 g, 0.021 mol, 1 eq.) was dissolved in 1,4-dioxane (30 mL) at room temperature and selenium dioxide (2.9 g, 0.026 mol, 1.2 eq.) was added with stirring. The reaction mixture was heated to reflux and stirred continuously for 16 hours. Upon completion of the reaction, the mixture was cooled to room temperature and filtered to remove insoluble material. The filtrate was concentrated under reduced pressure and diluted with ethyl acetate (50 mL) and subsequently washed with water (50 mL). The organic phase was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 5-nitropyridine-2-carbaldehyde (3.12 g, 94% yield).
References
[1] Patent: WO2013/13815, 2013, A1. Location in patent: Page/Page column 230; 231
[2] Patent: US2013/29962, 2013, A1. Location in patent: Paragraph 1110
[3] Journal of Organic Chemistry, 2012, vol. 77, # 20, p. 8968 - 8979,12
[4] Journal of Medicinal Chemistry, 1992, vol. 35, # 20, p. 3672 - 3677
[5] Patent: WO2005/97752, 2005, A1. Location in patent: Page/Page column 42
3-NITRO-6-PYRIDINECARBOXALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-NITRO-6-PYRIDINECARBOXALDEHYDE manufacturers
- Product
- 5-nitropyridine-2-carbaldehyde 35969-75-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- 100kgs/month
- Release date
- 2021-11-21
- Product
- 3-NITRO-6-PYRIDINECARBOXALDEHYDE 35969-75-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-03