5,6-DIPHENYLPYRAZIN-2-OL
- Product Name
- 5,6-DIPHENYLPYRAZIN-2-OL
- CAS No.
- 18591-57-6
- Chemical Name
- 5,6-DIPHENYLPYRAZIN-2-OL
- Synonyms
- Selexipag Impurity 30;Selexipag Impurity 10;5,6-Diphenylpyrazinol;5,6-diphenylpyrazin-2-yl;5,6-DIPHENYLPYRAZIN-2-OL;5,6-Diphenyl-2(1H)-pyrazinone;5,6-diphenylpyrazin-2(1H)-one;5,6-diphenyl-1H-pyrazin-2-one;5,6-Diphenyl-2-hydroxypyrazine;2(1H)-Pyrazinone, 5,6-diphenyl-
- CBNumber
- CB9225204
- Molecular Formula
- C16H12N2O
- Formula Weight
- 248.28
- MOL File
- Mol file
5,6-DIPHENYLPYRAZIN-2-OL Property
- Melting point:
- 225-227 °C
- Density
- 1.17±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 10.55±0.60(Predicted)
- Appearance
- Light yellow to yellow Solid
- InChI
- InChI=1S/C16H12N2O/c19-14-11-17-15(12-7-3-1-4-8-12)16(18-14)13-9-5-2-6-10-13/h1-11H,(H,18,19)
- InChIKey
- LTWBZUZTTUVPIM-UHFFFAOYSA-N
- SMILES
- C1(=O)NC(C2=CC=CC=C2)=C(C2=CC=CC=C2)N=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H360May damage fertility or the unborn child
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D415285
- Product name
- 5,6-Diphenylpyrazinol
- Packaging
- 25g
- Price
- $180
- Updated
- 2021/12/16
- Product number
- 8595BA
- Product name
- 5,6-Diphenylpyrazin-2-ol
- Packaging
- 5g
- Price
- $107
- Updated
- 2021/12/16
- Product number
- API0046125
- Product name
- SELEXIPAG EP IMPURITY B
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $455.23
- Updated
- 2021/12/16
- Product number
- 18591576
- Product name
- 5,6-Diphenylpyrazin-2-ol
- Packaging
- 100g
- Price
- $543.51
- Updated
- 2021/12/16
- Product number
- CM250681
- Product name
- 5,6-Diphenylpyrazin-2-ol
- Purity
- 95%+
- Packaging
- 25g
- Price
- $119
- Updated
- 2021/12/16
5,6-DIPHENYLPYRAZIN-2-OL Chemical Properties,Usage,Production
Uses
5,6-Diphenylpyrazinol is a diphenylpyrazine derivative which belongs to a class of prostacyclin receptor agonists. It is impurity of Selexipag (S253150) that is a potential drug for the treatment of various vascular disorders such as pulmonary arterial hypertension and arteriosclerosis obliterans.
Synthesis
1668-10-6
134-81-6
18591-57-6
General procedure for the synthesis of 5,6-diphenyl-2-hydroxypyrazine from glycinamide hydrochloride and biphenylformamide: Biphenylformamide (62.0 g, 0.29 mol), glycinamide hydrochloride (35.37 g, 0.32 mol), and NaOH (23.2 g, 0.58 mol) were added sequentially to 500 mL of methanol, and heated at reflux under nitrogen protection for 3 to 4 hours. The reaction progress was monitored by LC-MS until the ingredients were fully reacted. The reaction solution was cooled to 0-5 °C, and 12N HCl (38 mL) was added slowly and dropwise, followed by stirring for 30 min at room temperature. To the reaction solution was added 30 g of sodium bicarbonate and 350 mL of water, followed by washing with water (20 mL) and methanol (20 mL). The solid product was collected and dried under vacuum to give 65.5 g of 5,6-diphenyl-2-hydroxypyrazine as a white solid in 91.1% yield.
References
[1] Patent: CN108623541, 2018, A. Location in patent: Paragraph 0049-0051; 0069-0072; 0089-0091; 0108-0110; 0127
[2] Patent: US2015/147840, 2015, A1. Location in patent: Page/Page column
[3] Patent: WO2017/60827, 2017, A1. Location in patent: Page/Page column 11
[4] Patent: US2015/147840, 2015, A1. Location in patent: Page/Page column
[5] Patent: US2016/108006, 2016, A1. Location in patent: Paragraph 0173-0175
5,6-DIPHENYLPYRAZIN-2-OL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5,6-DIPHENYLPYRAZIN-2-OL manufacturers
- Product
- 5,6-DIPHENYLPYRAZIN-2-OL 18951-57-6
- Price
- US $3.00-0.20/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-03-26
- Product
- 5,6-DIPHENYLPYRAZIN-2-OL 18591-57-6
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-02-13